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Translating research into prevention of high-risk behaviors in the presence of complex systems: definitions and systems frameworks

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Translational Behavioral Medicine

Abstract

To impact population health, it is critical to collaborate across disciplinary and practice-based silos and integrate resources, experiences, and knowledge to exert positive change. Complex systems shape both the prevention outcomes researchers, practitioners, and policymakers seek to impact and how research is translated and can either impede or support movement from basic scientific discovery to impactful and scaled-up prevention practice. Systems science methods can be used to facilitate designing translation support that is grounded in a richer understanding of the many interacting forces affecting prevention outcomes across contexts. In this paper, we illustrate how one systems science method, system dynamics, could be used to advance research, practice, and policy initiatives in each stage of translation from discovery to translation of innovation into global communities (T0-T5), with tobacco prevention as an example. System dynamics can be applied to each translational stage to integrate disciplinary knowledge and document testable hypotheses to inform translation research and practice.

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References

  1. Balas EA, Boren SA. Managing clinical knowledge for health care improvement. In: Bemmel J, McCray AT, eds. Yearbook of Medical Informatics 2000: Patient-Centered Systems. Stuttgart, Germany: Schattauer Verlagsgesellschaft mbH; 2000: 65-70.

    Google Scholar 

  2. Harris JK, Luke DA, Zuckerman RB, et al. Forty years of secondhand smoke research: the gap between discovery and delivery. Am J Prev Med. 2009; 36: 538-548.

    Article  PubMed  Google Scholar 

  3. Kreuter MW, Bernhardt JM. Reframing the dissemination challenge: a marketing and distribution perspective. Am J Public Health. 2009; 99: 2123-2127.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Lenfant C. Shattuck lecture--clinical research to clinical practice--lost in translation? N Engl J Med. 2003; 349: 868-874.

    Article  PubMed  Google Scholar 

  5. Stevens KR, Staley JM. The Quality Chasm reports, evidence-based practice, and nursing’s response to improve healthcare. Nurs Outlook. 2006; 54: 94-101.

    Article  PubMed  Google Scholar 

  6. Fishbein DH, Stahl M, Ridenour T, et al. The Full Translational Spectrum of Prevention Science: Emerging Basic and Applied Research to Support Scaling Up Proven Practices That Prevent Behavioral Health Problems. Trans Behav Med. 2016.

  7. Centers for Disease Control and Prevention. Best practices for comprehensive tobacco control programs. Atlanta, GA: U.S.: Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health;1999.

  8. Food and Drug Administration. Regulations restricting the sale and distribution of cigarettes and smokeless tobacco products to protect children and adolescents. Fed Regist. 1995; 11: 41314-41451.

    Google Scholar 

  9. Institute of Medicine. State Programs Can Reduce Tobacco Use. Washington DC: National Cancer Policy Board, Institute of Medicine, National Research Council; 2000.

  10. US Department of Health and Human Services. Substance abuse prevention and treatment block grants: Sale or distribution of tobacco products to individuals under 18 years of age (45 CFR Pt. 96). Fed Regist. 1993; 58: 45156-45174.

    Google Scholar 

  11. Craig MJ, Boris NW. Youth tobacco access restrictions: time to shift resources to other interventions? Health Promot Pract. 2007; 8: 22-27.

    Article  PubMed  Google Scholar 

  12. Etter JF. Laws prohibiting the sale of tobacco to minors: impact and adverse consequences. Am J Prev Med. 2006; 31: 47-51.

    Article  PubMed  Google Scholar 

  13. Glantz SA. Limiting youth access to tobacco: a failed intervention. J Adolesc Health. 2002; 31: 301-302.

    Article  PubMed  Google Scholar 

  14. Jason LA, Pokorny SB, Muldowney K, et al. Youth tobacco sales-to-minors and possession-use-purchase laws: a public health controversy. J Drug Educ. 2005; 35: 275-290.

    Article  PubMed  Google Scholar 

  15. O’Loughlin J, Karp I, Koulis T, et al. Determinants of first puff and daily cigarette smoking in adolescents. Am J Epidemiol. 2009; 170: 585-597.

    Article  PubMed  Google Scholar 

  16. Pentz MA, Sussman S, Newman T. The conflict between least harm and no-use tobacco policy for youth: ethical and policy implications. Addiction. 1997; 92: 1165-1173.

    Article  CAS  PubMed  Google Scholar 

  17. Robinson J, Amos A. A qualitative study of young people’s sources of cigarettes and attempts to circumvent underage sales laws. Addiction. 2010; 105: 1835-1843.

    Article  PubMed  Google Scholar 

  18. Spivak AL, Monnat SM. Prohibiting juvenile access to tobacco: violation rates, cigarette sales, and youth smoking. Int J Drug Policy. 2015; 26: 851-859.

    Article  PubMed  Google Scholar 

  19. Tworek C, Yamaguchi R, Kloska DD, et al. State-level tobacco control policies and youth smoking cessation measures. Health Policy. 2010; 97: 136-144.

    Article  PubMed  PubMed Central  Google Scholar 

  20. White MM, Gilpin EA, Emery SL, et al. Facilitating adolescent smoking: who provides the cigarettes? Am J Health Promot. 2005; 19: 355-360.

    Article  PubMed  Google Scholar 

  21. Best A. National Cancer Institute (U.S.). Greater than the sum: systems thinking in tobacco control. Bethesda, MD: National Cancer Institute, U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health; 2007.

    Google Scholar 

  22. Marcus SE, Leischow SJ, Mabry PL, et al. Lessons learned from the application of systems science to tobacco control at the National Cancer Institute. Am J Public Health. 2010; 100: 1163-1165.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Sussman S, Levy D, Lich KH, et al. Comparing effects of tobacco use prevention modalities: need for complex system models. Tob Induc Dis. 2013; 11: 2.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Hassmiller Lich K, Ginexi EM, Osgood ND, et al. A call to address complexity in prevention science research. Prev Sci. 2013; 14: 279-289.

    Article  Google Scholar 

  25. Sterman JD. Learning from evidence in a complex world. Am J Public Health. 2006; 96: 505-514.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Cohen IR, Harel D. Explaining a complex living system: dynamics, multi-scaling and emergence. J R Soc Interface. 2006; 4: 175-182.

    Article  PubMed Central  Google Scholar 

  27. Weiner BJ, Lewis MA, Clauser SB, et al. In search of synergy: strategies for combining interventions at multiple levels. J Natl Cancer Inst Monogr. 2012; 2012: 34-41.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Hassmiller Lich K, Minyard K, Niles R, et al. System dynamics and community health. In: Burke JG, Albert S, eds. Emerging Methods In. Community Public Health Research: Springer Publishing Company; 2014.

    Google Scholar 

  29. Luke DA, Stamatakis KA. Systems science methods in public health: dynamics, networks, and agents. Annu Rev Public Health. 2012; 33: 357-376.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Levine RL, Fitzgerald HE. Analysis of Dynamic Psychological Systems. New York: Plenum Press; 1992.

    Book  Google Scholar 

  31. Pentz MA. Institutionalizing community-based prevention through policy change. Special CSAP issue. J Commun Psychol. 2000; 28: 257-270.

    Article  Google Scholar 

  32. Sterman JD. Business Dynamics: Systems Thinking and Modeling for a Complex World. Boston: Irwin/McGraw-Hill; 2000.

    Google Scholar 

  33. Gillen EM, Hassmiller Lich, K., Yeatts KB, et al. Social Ecology of Asthma: Engaging Stakeholders in Integrating Health Behavior Theories and Practice-Based Evidence Through Systems Mapping. Health Educ Behav. 2013

  34. Hovmand PS, Andersen DF, Rouwette E, et al. Group model-building ‘Scripts’ as a collaborative planning tool. Syst Res Behav Sci. 2012; 29: 179-193.

    Article  Google Scholar 

  35. Richardson, GP. Concept models in group model building. Syst Dyn Rev. 2013; 29: 42-55.

  36. Richardson GP, Andersen DF. Teamwork in group model-building. Syst Dyn Rev. 1995; 11: 113-137.

    Article  Google Scholar 

  37. Vennix JAM. Group model Building: Facilitating Team Learning Using System Dynamics. Chichester. New York: J. Wiley; 1996.

    Google Scholar 

  38. Shonkoff JP. From neurons to neighborhoods: old and new challenges for developmental and behavioral pediatrics. J Dev Behav Pediatr. 2003; 24: 70-76.

    Article  PubMed  Google Scholar 

  39. Ahmad S. The cost-effectiveness of raising the legal smoking age in California. Med Decis Making. 2005; 25: 330-340.

    Article  PubMed  Google Scholar 

  40. Ahmad S. Increasing excise taxes on cigarettes in California: a dynamic simulation of health and economic impacts. Prev Med. 2005; 41: 276-283.

    Article  PubMed  Google Scholar 

  41. Ahmad S. Closing the youth access gap: the projected health benefits and cost savings of a national policy to raise the legal smoking age to 21 in the United States. Health Policy. 2005; 75: 74-84.

    Article  PubMed  Google Scholar 

  42. Ahmad S, Billimek J. Estimating the health impacts of tobacco harm reduction policies: a simulation modeling approach. Risk Anal. 2005; 25: 801-812.

    Article  PubMed  Google Scholar 

  43. Ahmad S, Billimek J. Limiting youth access to tobacco: comparing the long-term health impacts of increasing cigarette excise taxes and raising the legal smoking age to 21 in the United States. Health Policy. 2007; 80: 378-391.

    Article  PubMed  Google Scholar 

  44. Ahmad S, Franz GA. Raising taxes to reduce smoking prevalence in the US: a simulation of the anticipated health and economic impacts. Public Health. 2008; 122: 3-10.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Cavana RY, Clifford LV. Demonstrating the utility of system dynamics for public policy analysis in New Zealand: the case of excise tax policy on tobacco. Syst Dyn Rev. 2006; 22: 321-348.

    Article  Google Scholar 

  46. Cavana RY, Tobias MI. Integrative system dynamics: analysis of policy options for tobacco control in New Zealand. Syst Res Behav Sci. 2008; 25: 675-694.

    Article  Google Scholar 

  47. Homer J, Hirsch G, Milstein B, Homer J, Hirsch G, Milstein B. Chronic illness in a complex health economy: the perils and promises of downstream and upstream reforms. Syst Dyn Rev. 2007; 23: 313-343.

    Article  Google Scholar 

  48. Houle B, Siegel M. Smoker-free workplace policies: developing a model of public health consequences of workplace policies barring employment to smokers. Tob Control. 2009; 18: 64-69.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Lounsbury DW, Hirsch GB, Vega C, et al. Understanding social forces involved in diabetes outcomes: a systems science approach to quality-of-life research. Qual Life Res. 2014; 23: 959-969.

    Article  PubMed  Google Scholar 

  50. Mendez D, Alshanqeety O, Warner KE. The potential impact of smoking control policies on future global smoking trends. Tob Control. 2013; 22: 46-51.

    Article  PubMed  Google Scholar 

  51. Milstein B, Homer J, Briss P, et al. Why behavioral and environmental interventions are needed to improve health at lower cost. Health Aff (Millwood). 2011; 30: 823-832.

    Article  Google Scholar 

  52. Tengs TO, Ahmad S, Moore R, et al. Federal policy mandating safer cigarettes: a hypothetical simulation of the anticipated population health gains or losses. J Policy Anal Manag J Assoc Pub Policy Anal Manag. 2004; 23: 857-872.

    Article  Google Scholar 

  53. Tengs TO, Ahmad S, Savage JM, et al. The AMA proposal to mandate nicotine reduction in cigarettes: a simulation of the population health impacts. Prev Med. 2005; 40: 170-180.

    Article  PubMed  Google Scholar 

  54. Tengs TO, Osgood ND, Chen LL. The cost-effectiveness of intensive national school-based anti-tobacco education: results from the tobacco policy model. Prev Med. 2001; 33: 558-570.

    Article  CAS  PubMed  Google Scholar 

  55. Tengs TO, Osgood ND, Lin TH. Public health impact of changes in smoking behavior: results from the Tobacco Policy Model. Med Care. 2001; 39: 1131-1141.

    Article  CAS  PubMed  Google Scholar 

  56. Tobias MI, Cavana RY, Bloomfield A. Application of a system dynamics model to inform investment in smoking cessation services in New Zealand. Am J Public Health. 2010; 100: 1274-1281.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Hassmiller Lich K, Osgood N, Mahamoud A. Using system dynamics tools to gain insight into intervention options related to the interaction between tobacco and tuberculosis. Glob Health Promot. 2010; 17: 7-20.

    Article  PubMed  Google Scholar 

  58. Killeen PR. Markov model of smoking cessation. Proc Natl Acad Sci U S A. 2011; 108(Suppl 3): 15549-15556.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Niederdeppe J, Avery R, Byrne S, et al. Variations in state use of antitobacco message themes predict youth smoking prevalence in the USA, 1999–2005. Tob Control. 2016; 25: 101-107.

    PubMed  Google Scholar 

  60. Cavana RY, Tobias M. Integrative system dynamics: analysis of policy options for tobacco control in New Zealand. Syst Res Behav Sci. 2008; 25: 675-694.

    Article  Google Scholar 

  61. Milstein B, Homer J, Briss P, et al. Why behavioral and environmental interventions are needed to improve health at lower cost. Health Aff. 2011; 30: 823-832.

    Article  Google Scholar 

  62. Burke JG, Hassmiller Lich K, Neal JW, et al. Enhancing dissemination and implementation research using systems science methods. Int J Behav Med. 2015; 22: 283-291.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Pentz MA. Form follows function: designs for prevention effectiveness and diffusion research. Prev Sci. 2004; 5: 23-29.

    Article  PubMed  Google Scholar 

  64. Jalali MS, Rahmandad H, Bullock SL, et al. Dynamics of obesity interventions inside organizations. Paper presented at: The 32nd International Conference of the System Dynamics Society.2014, July.

  65. Saltelli A. Global sensitivity analysis : the primer. Chichester, England. Hoboken, NJ: John Wiley; 2008.

    Google Scholar 

  66. Pentz MA, Mares D, Schinke S, et al. Political science, public policy, and drug use prevention. Subst Use Misuse. 2004; 39: 1821-1865.

    Article  PubMed  Google Scholar 

  67. Sterman JD. Learning in and about complex systems. Syst Dynam Rev. 1994; 10: 291-330.

    Article  Google Scholar 

  68. Vennix JAM. Group model-building: tackling messy problems. Syst Dyn Rev. 1999; 15: 379-401.

    Article  Google Scholar 

  69. Loyo HK, Batcher C, Wile K, et al. From model to action: using a system dynamics model of chronic disease risks to align community action. Health Promot Pract. 2013; 14: 53-61.

    Article  PubMed  Google Scholar 

  70. Vennix JAM, Akkermans HA, Rouwette EAJA. Group model-building to facilitate organizational change: an exploratory study. Syst Dyn Rev. 1996; 12: 39-58.

    Article  Google Scholar 

  71. Ghaffarzadegan N, Lyneis J, Richardson GP. How small system dynamics models can help the public policy process. Syst Dyn Rev. 2011; 27: 22-44.

    Google Scholar 

  72. Morrissey JP, Lich KH, Price RA, et al. Computational modeling and multilevel cancer control interventions. J Natl Cancer Inst Monogr. 2012; 2012: 56-66.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Lich KH, Ginexi EM, Osgood ND, et al. A call to address complexity in prevention science research. Prev Sci. 2013; 14: 279-289.

    Article  PubMed  Google Scholar 

  74. Valente TW, Palinkas LA, Czaja S, et al. Social network analysis for program implementation. PLoS ONE. 2015; 10: e0131712.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Marshall BD, Paczkowski MM, Seemann L, et al. A complex systems approach to evaluate HIV prevention in metropolitan areas: preliminary implications for combination intervention strategies. PLoS ONE. 2012; 7: e44833.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Gittelsohn J, Mui Y, Adam A, et al. Incorporating systems science principles into the development of obesity prevention interventions: principles, benefits, and challenges. Curr Obes Rep. 2015; 4: 174-181.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Gittelsohn J, Anderson Steeves E, Mui Y, et al. B’More healthy communities for kids: design of a multi-level intervention for obesity prevention for low-income African American children. BMC Public Health. 2014; 14: 942.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Trochim W, Kane C, Graham MJ, et al. Evaluating translational research: a process marker model. Clin Transl Sci. 2011; 4: 153-162.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Rajan A, Sullivan R, Bakker S, et al. Critical appraisal of translational research models for suitability in performance assessment of cancer centers. Oncologist. 2012; 17: e48-57.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Kriste Hassmiller Lich Ph.D.

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This article does not contain any studies with human participants performed by any of the authors.

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Implications

Researchers: System dynamics tools offer an approach to integrating science, data, and stakeholders’ knowledge into explicit and testable mechanistic hypotheses about prevention outcomes that can strengthen research over time and across translational stages.

Practitioners: System dynamics diagrams offer a mechanism for describing practitioners’ understanding of the most important cross-system factors shaping behavioral outcomes, which informs action planning and helps practitioners communicate their intuition about how to improve systems.

Policymakers: System dynamics diagramming creates explicit theories of change that will inform decision-making in the context of dynamically complex systems problems and increase return on investment.

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Hassmiller Lich, K., Frerichs, L., Fishbein, D. et al. Translating research into prevention of high-risk behaviors in the presence of complex systems: definitions and systems frameworks. Behav. Med. Pract. Policy Res. 6, 17–31 (2016). https://doi.org/10.1007/s13142-016-0390-z

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