Translational Behavioral Medicine

, Volume 5, Issue 3, pp 294–306 | Cite as

Computer-based HIV adherence promotion interventions: a systematic review

Translation Behavioral Medicine
  • Kasey R. ClabornEmail author
  • Anne Fernandez
  • Tyler Wray
  • Susan Ramsey
Systematic Reviews


Researchers have instituted a range of methodologies to increase access to HIV adherence interventions. This article reviews studies published through January 2014 utilizing computer-based delivery of such interventions to persons living with HIV. A systematic review of five databases identified ten studies (three RCTs, three pilot studies, three feasibility studies, and one single-group trial) that met the inclusion criteria. Descriptions of the interventions’ content and characteristics are included. Interventions varied widely in terms of program structure, theoretical framework, and content. Only six studies reported medication adherence outcomes. Of these, four (five RCTS and one single group pre-post test) reported significant improvement in adherence using various measures, and two approached significance. Results suggest that computer-delivered adherence interventions are feasible and acceptable among both HIV-positive adolescents and adults. Definitive conclusions regarding clinical impact cannot be drawn due to the small number of adequately powered randomized trials in this review. Additional randomized controlled research is needed to draw inferences regarding intervention efficacy.


Computer-based intervention HIV Adherence eHealth 



This was an investigator-initiated study supported in part by grant number T32 AA007459 from the National Institute on Alcohol Abuse and Alcoholism at the National Institutes of Health. The funders played no role in the design, conduct or analysis of the study, nor in the interpretation and reporting of the study findings. All authors had full access to all of the data in the study (including statistical reports and tables) and can take responsibility for the integrity of the data and the accuracy of the data analysis.

Conflict of Interest

Kasey Claborn, Anne Fernandez, Tyler Wray, and Susan Ramsey declare that they have no conflict of interest.


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Copyright information

© Society of Behavioral Medicine 2015

Authors and Affiliations

  • Kasey R. Claborn
    • 1
    • 3
    Email author
  • Anne Fernandez
    • 1
  • Tyler Wray
    • 1
  • Susan Ramsey
    • 2
  1. 1.Center for Alcohol and Addiction Studies and the Alcohol Research Center on HIVBrown UniversityProvidenceUSA
  2. 2.Brown University School of Medicine and Rhode Island HospitalProvidenceUSA
  3. 3.ProvidenceUSA

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