Abstract
68Ga-labeled somatostatin receptor analogs physiologic distribution patterns have become recognizable among nuclear medicine physicians because of the increasing routine clinical use of this modality in the work-up of neuroendocrine tumors. Some pitfalls during 68Ga-labeled somatostatin receptor PET/CT have recently been reported as causes of misdiagnoses. Iatrogenic microembolism as a cause of 18F-FDG embolus is well-established; however, 68Ga-DOTATOC embolus is not well documented in the literature. In the current case, the presence and the spontaneous resolution of the 68Ga-labeled somatostatin receptor analogs embolus during sequential PET/CT are nicely demonstrated. Awareness of this incidental finding would avoid misdiagnosis and unnecessary investigations.
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References
Özgüven S, Filizoğlu N, Kesim S, Öksüzoğlu K, Şen F, Öneş T, et al. Physiological biodistribution of 68Ga-DOTA-TATE in normal subjects. Mol Imaging Radionucl Ther. 2021;30:39–46.
Al-Ibraheem A, Bundschuh RA, Notni J, Buck A, Winter A, Wester HJ, et al. Focal uptake of 68Ga-DOTATOC in the pancreas: pathological or physiological correlate in patients with neuroendocrine tumours? Eur J Nucl Med Mol Imaging. 2011;38:2005–13.
Shastry M, Kayani I, Wild D, Caplin M, Visvikis D, Gacinovic S, et al. Distribution pattern of 68Ga-DOTATATE in disease-free patients. Nucl Med Commun. 2010;31:1025–32.
Khalaf A, Hirmas N, Anwer F, Al-Ibraheem A. 68Ga DOTA-TOC uptake in non-ossifying fibroma: a case report. Nucl Med Mol Imaging. 2020;54:199–203.
Hofman MS, Lau WF, Hicks RJ. Somatostatin receptor imaging with 68Ga DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation. Radiographics. 2015;35:500–16.
Chondrogiannis S, Marzola MC, Grassetto G, Zorzi A, Milan E, Rampin L, et al. 18F-FDG PET/CT lung ‘focalities’ without coregistered CT findings: an interpretative clinical dilemma. Nucl Med Commun. 2015;36:334–9.
Panagiotidis E, Seshadri N, Fernando R, Healey P, Vinjamuri S. 68Ga-DOTANOC focal pulmonary activity with no corresponding CT abnormality. Clin Nucl Med. 2016;4:948–50.
Acknowledgements
Authors would like to thank Ms. Safa’a Al-Bashayreh for preparing the radiolabelled peptide and the team of nuclear medicine department at KHCC for their dedicated work.
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Al-Ibraheem, A., Sweedat, D.A., Anwer, F. et al. 68Ga-DOTATOC Embolus Manifestation and Spontaneous Resolution by PET/CT. Nucl Med Mol Imaging 56, 208–210 (2022). https://doi.org/10.1007/s13139-022-00752-8
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DOI: https://doi.org/10.1007/s13139-022-00752-8