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Mismatched Imaging Findings of Prostate Cancer Diagnosis: 68 Ga-PSMA PET/CT vs mpMRI

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Abstract

Multiparametric magnetic resonance imaging (mpMRI) is the modality of choice for initial diagnosis of prostate cancer (PCa), including biopsy-naïve patients. Nevertheless, clinicians must be aware of the possibility that up to one-fourth of clinically significant cancers might be missed by the modality. Acknowledgment of this occurrence and the increased availability of 68 Ga-PSMA PET/CT in clinical routine, open the door to new, fascinating, indications for this functional modality in the context of PCa detection. With the case herein illustrated, we report a paradigmatic example of mismatch findings between PET/CT and mpMRI better elucidating the potential indication.

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Data availability

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

Abbreviations

DCE:

Dynamic contrast enhanced

DRE:

Digital rectal examination

DWI-ADC:

Diffusion-weighted imaging-apparent diffusion coefficient

EAU:

European Association of Urology

GS:

Gleason score

mpMRI:

Multiparametric magnetic resonance imaging

PCa:

Prostate cancer

PET/CT:

Positron emission tomography/computed tomography

PI-RADS:

Prostate imaging reporting and data system

PSA:

Prostate-specific antigen

PSMA:

Prostate-specific membrane antigen

RALP:

Robotic-assisted laparoscopic prostatectomy

ROIs:

Regions of interest

SUV:

Standardized uptake value

TRUS:

Transrectal ultrasound

References

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Acknowledgements

The authors would like to thank Nadia Lo Iacono of the Urology Department for the collection of the clinical data and Federica Mrakic Sposta of the Departments of Radiology for the multiparametric MRI assessment.

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Authors and Affiliations

  1. Nuclear Medicine Unit, IRCCS - Humanitas Research Hospital, Via Manzoni 56, CAP 20089, Rozzano, MI, Italy

    Egesta Lopci

  2. Pathology, IRCCS - Humanitas Research Hospital, Rozzano, MI, Italy

    Piergiuseppe Colombo

  3. Urology, IRCCS - Humanitas Research Hospital, Rozzano, MI, Italy

    Massimo Lazzeri

Authors
  1. Egesta Lopci
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  2. Piergiuseppe Colombo
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  3. Massimo Lazzeri
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Contributions

Egesta Lopci contributed in planning, conception, data acquisition, analysis, and reporting of the work in the current paper. Piergiuseppe Colombo contributed in data collection and final approval of manuscript. Massimo Lazzeri contributed in study conduct, manuscript revision, and final approval of the work.

Corresponding author

Correspondence to Egesta Lopci.

Ethics declarations

Ethical approval and consent to participate

All procedures performed involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individuals.

Consent for publication

The patient has signed a general informed consent for scientific publication.

Competing interests

Egesta Lopci reports receiving grants from Fondazione AIRC (Associazione Italiana per la Ricerca sul Cancro) and from the Italian Ministry of Health, and faculty remuneration from ESMIT (European School of Multimodality Imaging & Therapy) and MI&T congress. Piergiuseppe Colombo and Massimo Lazzeri declare that they have no conflict of interest.

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Lopci, E., Colombo, P. & Lazzeri, M. Mismatched Imaging Findings of Prostate Cancer Diagnosis: 68 Ga-PSMA PET/CT vs mpMRI. Nucl Med Mol Imaging 55, 199–202 (2021). https://doi.org/10.1007/s13139-021-00701-x

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  • DOI: https://doi.org/10.1007/s13139-021-00701-x

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