Abstract
The positron emission tomography (PET) flow tracer 82Rubidium is a known potassium analogue. During our studies of tumor blood flow in prostate cancer, we found that approximately 10% of the patients had high urinary 82Rubidium activity. In roughly half of these patients, the increased renal rubidium/potassium excretion was either causing hypokalemia or explained by Thiazide treatment. In the other half, there was no obvious explanation or clinical consequence of the renal rubidium/potassium excretion. This is the first time enhanced renal potassium excretion is visualized on 82Rubidium PET/CT.
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Funding
This study was supported by a grant from The Danish Cancer Society, Health Research Fund of Central Denmark Region, P. Carl Petersens Fond, and Dansk Kræftforskningsfond.
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Mads Ryø Jochumsen, Lars Poulsen Tolbod, Michael Borre, Jørgen Frøkiær, Kirsten Bouchelouche, and Jens Sörensen declare that they have no conflict of interest.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.
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Informed consent was obtained from all individual participants included in the study.
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Jochumsen, M.R., Tolbod, L.P., Borre, M. et al. Renal Potassium Excretion Visualized on 82Rubidium PET/CT. Nucl Med Mol Imaging 54, 120–122 (2020). https://doi.org/10.1007/s13139-020-00637-8
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DOI: https://doi.org/10.1007/s13139-020-00637-8