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68Ga-PSMA: a One-stop Shop in Radioactive Iodine Refractory Thyroid Cancer?

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Abstract

We report a case of a 47-year-old female known with metastatic papillary thyroid cancer. Her treatment history included total thyroidectomy and 3 previous radio ablations with a cumulative dose of 950 mCi of 131I. On follow-up, her thyroglobulin levels had demonstrated a rising trend (from 3789.0 to 4240.0 ug/L) despite a 123I whole-body scan demonstrating a reduction in tracer avid lesions. She was suspected of having radio-resistant disease. The patient underwent both 18F-FDG and 68Ga-PSMA PET/CT imaging with both scans demonstrating congruent lesions however with far greater intensity on the 68Ga-PSMA study.

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Acknowledgments

We would like to thank the staff of the Department of Nuclear Medicine of Steve Biko Academic Hospital for performing the scans.

Funding

This study was self-funded by the Department of Nuclear Medicine.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Private Bag X169, Pretoria, 0001, South Africa

    Thabo Lengana, Ismaheel O. Lawal, Kgomotso Mokoala, Mariza Vorster & Mike M. Sathekge

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  1. Thabo Lengana
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  2. Ismaheel O. Lawal
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  3. Kgomotso Mokoala
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  4. Mariza Vorster
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  5. Mike M. Sathekge
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Correspondence to Mike M. Sathekge.

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Conflict of Interest

Thabo Lengana, Ismaheel O. Lawal, Kgomotso Mokoala, Mariza Vorster, and Mike M. Sathekge declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Lengana, T., Lawal, I.O., Mokoala, K. et al. 68Ga-PSMA: a One-stop Shop in Radioactive Iodine Refractory Thyroid Cancer?. Nucl Med Mol Imaging 53, 442–445 (2019). https://doi.org/10.1007/s13139-019-00621-x

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  • DOI: https://doi.org/10.1007/s13139-019-00621-x

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