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Nuclear Medicine and Molecular Imaging

, Volume 53, Issue 1, pp 14–29 | Cite as

Radiomics in Oncological PET/CT: a Methodological Overview

  • Seunggyun Ha
  • Hongyoon Choi
  • Jin Chul Paeng
  • Gi Jeong CheonEmail author
Review
First Online:
  • 45 Downloads

Abstract

Radiomics is a medical imaging analysis approach based on computer-vision. Metabolic radiomics in particular analyses the spatial distribution patterns of molecular metabolism on PET images. Measuring intratumoral heterogeneity via image is one of the main targets of radiomics research, and it aims to build a image-based model for better patient management. The workflow of radiomics using texture analysis follows these steps: 1) imaging (image acquisition and reconstruction); 2) preprocessing (segmentation & quantization); 3) quantification (texture matrix design & texture feature extraction); and 4) analysis (statistics and/or machine learning). The parameters or conditions at each of these steps are effect on the results. In statistical testing or modeling, problems such as multiple comparisons, dependence on other variables, and high dimensionality of small sample size data should be considered. Standardization of methodology and harmonization of image quality are one of the most important challenges with radiomics methodology. Even though there are current issues in radiomics methodology, it is expected that radiomics will be clinically useful in personalized medicine for oncology.

Keywords

Radiomics Texture analysis Intratumoral heterogeneity FDG PET/CT Oncology 

Abbreviations

AQ

Absolute quantization

AUC-CSH

Area under curve of cumulative SUV-volume histogram

CSH

Cumulative SUV-volume histogram

CV

Coefficient of variation

FBN

Fixed bin number

FBS

Fixed bin size

FCM

Fuzzy C-means

FDR

False-discovery rate

18F-FDG

18F-fluorodeoxyglucose

FLAB

Fuzzy locally adaptive Bayesian

GLCM

Gray-level co-occurrence matrix

GLRLM

Gray-level run-length matrix

GLSZM

Gray-level size zone matrix

IFH

Intensity frequency histogram

ITH

Intratumoral heterogeneity

IVH

Intensity volume histogram

MTV

Metabolic tumor volume

NGTDM

Neighborhood gray-tone difference matrix

PET/CT

Positron emission tomography/computed tomography

PVC

Partial volume correction

RQ

Relative quantization

SAM

Second angular moment

SGLDM

Spatial gray-level dependence matrix

SUV

Standardized uptake value

TLG

Total lesion glycolysis

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Notes

Compliance with Ethical Standards

Conflict of Interest

Seunggyun Ha, Hongyoon Choi, Jin Chul Paeng, and Gi Jeong Cheon declare no conflict of interest.

Ethical Statement

This work does not contain any studies with human participants or animals performed by any of the authors. For this type of study, formal consent is not required.

Informed Consent

Not applicable.

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© Korean Society of Nuclear Medicine 2019

Authors and Affiliations

  1. 1.Radiation Medicine Research InstituteSeoul National University College of MedicineSeoulSouth Korea
  2. 2.Department of Nuclear MedicineSeoul National University HospitalSeoulSouth Korea
  3. 3.Cancer Research InstituteSeoul National University College of MedicineSeoulSouth Korea

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