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Usefulness of Respiratory-Gated 18F-FDG PET/CT in Detecting Upper Abdominal Fever Focus

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Abstract

Respiratory-gated 18F-fluorodeoxygluocse (18F-FDG) PET/CT has been successfully used to better localize malignancies in the lung or upper abdominal organs. However, clinical usefulness of respiratory-gated 18F-FDG PET/CT in detection of fever focus has not been reported yet. A 68-year-old male patient with a history of living donor liver transplantation and biliary stenting was referred for 18F-FDG PET/CT due to fever of unknown origin (FUO). To find the accurate fever focus, respiratory-gated and non-gated 18F-FDG PET/CT was performed. Respiratory-gated PET/CT readily revealed prominent hypermetabolic lesion in the distal common bile duct (CBD) area where previous surgical graft was in situ. Maximum standardized uptake value (SUVmax) and SUV ratio (SUR) were greater in the gated PET/CT (SUVmax 5.4 and SUR 3.5) than in the non-gated PET/CT (SUVmax 4.6 and SUR 3.0). Fever dramatically subsided after removal of the graft in the CBD. This case report implies that respiratory-gated 18F-FDG PET/CT can visualize upper abdominal fever focus with better contrast than the conventional non-gated method.

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References

  1. Werner MK, Parker JA, Kolodny GM, English JR, Palmer MR. Respiratory gating enhances imaging of pulmonary nodules and measurement of tracer uptake in FDG PET/CT. AJR Am J Roentgenol. 2009;193:1640–5.

    Article  PubMed  Google Scholar 

  2. Van Der Gucht A, Serrano B, Hugonnet F, Paulmier B, Garnier N, Faraggi M. Impact of a new respiratory amplitude-based gating technique in evaluation of upper abdominal PET lesions. Eur J Radiol. 2014;83:509–15.

    Article  Google Scholar 

  3. Crivellaro C, De Ponti E, Elisei F, Morzenti S, Picchio M, Bettinardi V, et al. Added diagnostic value of respiratory-gated 4D 18F-FDG PET/CT in the detection of liver lesions: a multicenter study. Eur J Nucl Med Mol Imaging. 2018;45:102–9.

    Article  PubMed  Google Scholar 

  4. Buther F, Vehren T, Schafers KP, Schafers M. Impact of data-driven respiratory gating in clinical PET. Radiology. 2017;282:614–5.

    Article  PubMed  Google Scholar 

  5. Suenaga Y, Kitajima K, Aoki H, Okunaga T, Kono A, Matsumoto I, et al. Respiratory-gated (1)(8)F-FDG PET/CT for the diagnosis of liver metastasis. Eur J Radiol. 2013;82:1696–701.

    Article  PubMed  Google Scholar 

  6. Bailly P, Bouzerar R, Shields T, Meyer ME, Daouk J. Benefits of respiratory-gated 18F-FDG PET acquisition in lung disease. Nucl Med Commun. 2018;39:44–50.

    Article  PubMed  Google Scholar 

  7. Liu LH, Wang NY, Wu AY, Lin CC, Lee CM, Liu CP. Citrobacter freundii bacteremia: risk factors of mortality and prevalence of resistance genes. J Microbiol Immunol Infect. 2017; https://doi.org/10.1016/j.jmii.2016.08.016.

    Article  CAS  Google Scholar 

  8. Balink H, Verberne HJ, Bennink RJ, van Eck-Smit BL. A rationale for the use of F18-FDG PET/CT in fever and inflammation of unknown origin. Int J Mol Imaging. 2012;2012:165080.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Mingos M, Howard S, Giacalone N, Kozono D, Jacene H. Systemic immune response to vaccination on FDG-PET/CT. Nucl Med Mol Imaging. 2016;50:358–61.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea

    Sungwoo Bae, Yoo Sung Song & Won Woo Lee

  2. Department of Nuclear Medicine, Ewha Womans University School of Medicine, Seoul, South Korea

    Ji-In Bang

  3. Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, South Korea

    Won Woo Lee

Authors
  1. Sungwoo Bae
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  2. Ji-In Bang
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  3. Yoo Sung Song
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  4. Won Woo Lee
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Correspondence to Won Woo Lee.

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Conflict of Interest

Sungwoo Bae, Ji-In Bang, Yoo Sung Song, and Won Woo Lee declare that there is no conflict of interest. There was no funding source in this study.

Ethical Approval

The study was approved by our Institutional Review Board and was performed in accordance with the ethical standards of the 1964 Declaration of Helsinki and its later amendments.

Informed Consent

The need for patient’s informed consent was waived by the IRB.

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Bae, S., Bang, JI., Song, Y.S. et al. Usefulness of Respiratory-Gated 18F-FDG PET/CT in Detecting Upper Abdominal Fever Focus. Nucl Med Mol Imaging 52, 380–383 (2018). https://doi.org/10.1007/s13139-018-0534-9

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  • DOI: https://doi.org/10.1007/s13139-018-0534-9

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