Abstract
Nuclear medicine has been offering diagnostic and therapeutic solution since the introduction of radioactive iodine for thyroid diseases since decades. However, the concept of theranostics has given a new found impetus to the use of pairs of radiopharmaceuticals for diagnosis and treatment. Presented here is a perspective on theranostics from Pakistan.
Similar content being viewed by others
References
Younis N, Bashir H. Theranostics–neuroendocrine tumours. J Cancer Allied Spec. 2018;4(2):1.
Sawin CT, Becker DV. Radioiodine and the treatment of hyperthyroidism: the early history. Thyroid. 1997;7:163–76.
Sharp SE, Trout AT, Weiss BD, Gelfand MJ. MIBG in neuroblastoma diagnostic imaging and therapy. Radiographics. 2016;36:258–78.
Ahmadzahehfar H, Sabet A, Wilhelm K, Biersack HJ. Iodine-131-lipiodol therapy in hepatic tumours. Methods. 2011;55:246–52.
Rizzieri D. Z. (ibritumomabtiuxetan) after more than a decade of treatment experience, what have we learned. Crit Rev OncolHematol. 2016;105:5–17.
Handkiewicz-Junak D, Poeppel TD, Bodei L, Aktolun C, Ezziddin S, Giammarile F, et al. EANM guidelines for radionuclide therapy of bone metastases with beta-emitting radionuclides. Eur J Nucl Med Mol Imaging. 2018;45:846–59.
Kunikowska J, Lewington V, Krolicki L. Optimizing somatostatin receptor imaging in patients with neuroendocrine tumors: the impact of 99mTc-HYNICTOC SPECT/SPECT/CT versus 68Ga-DOTATATE PET/CT upon clinical management. Clin Nucl Med. 2017;42:905–11.
Ajit S. Rhenium 188: the poor Man’s yttrium. World J Nucl Med. 2017;16:1–2.
Zaman MU, Fatima N, Sajjad Z, Hashmi I. High-dose I131 therapy on outpatient basis: imperative and no more a desire. Pak J Nucl Med. 2012;2:92–7.
Memon AS, Laghari NA, Mangi FH, Hussain MM, Nohario SH. Isolation period of 131I administered patients at NIMRA Jamshoro Pakistan. Int J Radiol Radiat Ther. 2017;2:2–5.
Hassan A, Siddique M, Bashir H, Riaz S, Wali R, Mahreen A, et al. 18F-FDG PET-CT imaging versus bone marrow biopsy in pediatric Hodgkin’s lymphoma: a quantitative assessment of marrow uptake and novel insights into clinical implications of marrow involvement. Eur J Nucl Med Mol Imaging. 2017;44:1198–206.
Riaz S, Bashir H, Niazi IK. Triage of limited versus extensive disease on F18 FDG PET/CT scan in small cell lung cancer Asia Ocean. J Nucl Med Biol. 2017;5:109–13.
Riaz S, Bashir H, Hassan L, Jamshed A, Murtaza A, Hussain R. Impact and prognostic value of 18F FDG PET-CT scan in the evaluation of residual head and neck cancer - single centre experience from Pakistan. South Asian J Cancer. 2017;6:81–3.
Zaman MU, Fatima N, Zaman A, et al. Significantly low effective dose from 18FDG PET/CT scans using dose reducing strategies: “lesser is better”. Asian Pac J Cancer Prev. 2016;17:3465–8.
Riaz S, Nawaz MK, Faruqui ZS, Kazmi AS, Loya A, et al. Diagnostic accuracy of 18F-FDG PET-CT in the evaluation of carcinoma of unknown primary. Mol Imaging Radionucl Ther. 2016;25:1–10.
Bodei L, Brand MJ, Baum RP, Pavel ME, Horsch D, O’Dorisio MS, et al. The joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2013;40:800–16.
Strosberg J, El-Haddad G, Wolin E, Hendifar A, Chasen B, Mittra E, et al. Phase 3 trial of 177Lu-dotatate for midgut neuroendocrine tumors. N Engl J Med. 2017;376:125–35.
Strosberg J, Wolin E, Chasen B, Kulke M, Bushnell D, Caplin M, et al. Health-related quality of life in patients with progressive midgut neuroendocrine tumors treated with 177Lu-dotatate in the phase III NETTER-1 trial. J Clin Oncol. 2018;36:2578–84.
Mittra ES. Neuroendocrine tumor therapy: 177Lu-DOTATATE. Am J Roentgenol. 2018;211:278–85.
Virgolini I, Decristoforo C, Haug A, Fanti S, Uprimny C. Current status of theranostics in prostate cancer. Eur J Nucl Med Mol Imaging. 2018;45:471–95.
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, et al. [177Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study. Lancet Oncol. 2018;19:825–33.
Gavan SP, Thompson AJ, Payne K. The economic case for precision medicine. Expert Rev Precis Med Drug Dev. 2018;3:1–9.
Ajit S. An overview of nuclear medicine and PET CT in India. Curr Trends Clin Med Imaging. 2017;1(5).
Atutornu J, Hayre CM. Personalized medicine and medical imaging: opportunities and challenges for contemporary health care. J Med Imaging Radiat Sci. 2018;49:352–9.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
The authors declare that they have no conflict of interest.
Ethical Approval
All procedures quoted in the review articles involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed Consent
Informed content data exists for the quoted procedures in this review article.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Bashir, H., Numair Younis, M. & Rehan Gul, M. Nuclear Medicine Theranostics: Perspective from Pakistan. Nucl Med Mol Imaging 53, 38–41 (2019). https://doi.org/10.1007/s13139-018-00566-7
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13139-018-00566-7