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Quantification of Contraction Synchronicity and Contraction Work in Coronary Artery Disease

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Abstract

Purpose

This study quantified the contraction synchronicity (CS; with 100% representing full synchrony and −100% dyssynchrony) and contraction work (CW, millijoules per centimeter squared; representing myocardial area) in patients with reduced left ventricular ejection fraction (LVEF) associated with coronary artery disease (CAD).

Methods

CS, CW and LVEF in 104 subjects (54 CAD patients and 50 control subjects without CAD) were measured using rest electrocardiography-gated single-photon emission computed tomography (ECG SPECT). Contraction amplitude (CA), synchronous contraction index (SCI), and CW were evaluated using the program Quantification of Segmental Function by Solving the Poisson Equation (QSFP) developed in-house.

Results

The mean CA, SCI and CW of 17 segments in the control subjects were 33.8 ± 4.1% (±SD), 96.6 ± 1.4%, and 6.9 ± 1.0 mJ/cm2, respectively. In the patients with CAD, the respective values were 26.1 ± 7.3%, 82.1 ± 16.8%, and 5.4 ± 1.6 mJ/cm2. In the CAD patients with LVEF <40% (n = 14), the mean CA, SCI,and CW were 17.9 ± 4.0%, 63.0 ± 18.4%, and 3.5 ± 1.1 mJ/cm2, respectively. These values were significantly lower than in the control subjects (p < 0.005). Using receiver operating characteristic analysis, values for the area under the curve showing the performance of CA, CS, CW and LVEF in the diagnosis of CAD were 0.81, 0.86, 0.78, and 0.84, respectively.

Conclusion

Asynchrony shown using the QSFP is useful for CAD detection.

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Authors and Affiliations

  1. Department of Radiological Technology, Nagoya Daini Red Cross Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya, 466-8650, Japan

    Takanaga Niimi

  2. Cardiovascular Center, Nagoya Daini Red Cross Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya, 466-8650, Japan

    Mamoru Nanasato

  3. Department of Radiological Technology, Nagoya University School of Health Sciences, 1-1-20 Daiko-minami, Higashi-ku, Nagoya, 461-8673, Japan

    Hisatoshi Maeda

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  1. Takanaga Niimi
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  2. Mamoru Nanasato
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Correspondence to Takanaga Niimi.

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Conflict of Interest

Takanaga Niimi, Mamoru Nanasato and Hisatoshi Maeda declare that they have no conflict of interest associated with this study.

Ethical Approval

The study was approved by an institutional review board and was performed in accordance with the ethical standards laid down in the Helsinki Declaration of 1964 and later revisions. All subjects in the study gave written informed consent or the institutional review board waived the need to obtain informed consent.

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Niimi, T., Nanasato, M. & Maeda, H. Quantification of Contraction Synchronicity and Contraction Work in Coronary Artery Disease. Nucl Med Mol Imaging 51, 227–232 (2017). https://doi.org/10.1007/s13139-017-0472-y

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  • DOI: https://doi.org/10.1007/s13139-017-0472-y

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