Abstract
F-18 fluorodeoxyglucose (FDG) is a highly influential radiotracer that provides valuable information in many cancer types. However, the normal biodistribution of F-18 FDG is often variable and can be altered by intrinsic or iatrogenic factors. We report a case of diffuse symmetrically increased skeletal muscle uptake and relatively decreased hepatic uptake on F-18 FDG PET/CT in a 57-year-old female with pulmonary adenocarcinoma. Detailed clinical evaluation and retrospective radiologic evaluation revealed that she had been diagnosed with subacute thyroiditis 2 weeks ago. After 6 weeks, F-18 FDG distribution was normalized at the follow-up PET/CT study.
This is a preview of subscription content, log in via an institution to check access.
References
Alfadda AA, Sallam RM, Elawad GE, Aldhukair H, Alyahya MM. Subacute thyroiditis: clinical presentation and long term outcome. Int J Endocrinol. 2014;2014:794943.
Chen YK, Chen YL, Liao AC, Shen YY, Kao CH. Elevated 18F-FDG uptake in skeletal muscles and thymus: a clue for the diagnosis of Graves’ disease. Nucl Med Commun. 2004;25:115–21.
Chen YK, Chen YL, Tsui CC, Wang SC, Cheng RH. The significance of alteration 2-[fluorine-18]fluoro-2-deoxy-(D)-glucose uptake in the liver and skeletal muscles of patients with hyperthyroidism. Acad Radiol. 2013;20:1218–23.
Mitrou P, Raptis SA, Dimitriadis G. Insulin action in hyperthyroidism: a focus on muscle and adipose tissue. Endocr Rev. 2010;31:663–79.
Weinstein SP, O’Boyle E, Fisher M, Haber RS. Regulation of GLUT2 glucose transporter expression in liver by thyroid hormone: evidence for hormonal regulation of the hepatic glucose transport system. Endocrinology. 1994;135:649–54.
Silva JE. The multiple contributions of thyroid hormone to heat production. J Clin Invest. 2001;108:35–7.
Casla A, Rovira A, Wells JA, Dohm GL. Increased glucose transporter (GLUT4) protein expression in hyperthyroidism. Biochem Biophys Res Commun. 1990;171:182–8.
Potenza M, Via MA, Yanagisawa RT. Excess thyroid hormone and carbohydrate metabolism. Endocr Pract. 2009;15:254–62.
Weinstein SP, Watts J, Haber RS. Thyroid hormone increases muscle/fat glucose transporter gene expression in rat skeletal muscle. Endocrinology. 1991;129:455–64.
Lambert M, Jouret F, Lonneux M, Jamar F. Mismatch of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and Tc-99m pertechnetate thyroid scan in subacute thyroiditis. Acta Clin Belg. 2008;63:209–10.
Acknowledgments
This work was supported by Wonkwang University in 2015.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Myoung Hyoun Kim, Dae-Weung Kim, Soon-Ah Park and Chang Guhn Kim declare that they have no conflict of interest.
Ethical Approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed Consent
The institutional review board of our institute approved this retrospective study (WKUH 201603-HRE-023), and the requirement to obtain informed consent was waived.
Rights and permissions
About this article
Cite this article
Kim, M.H., Kim, DW., Park, SA. et al. Transiently Altered Distribution of F-18 FDG in a Patient with Subacute Thyroiditis. Nucl Med Mol Imaging 52, 82–84 (2018). https://doi.org/10.1007/s13139-016-0454-5
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13139-016-0454-5