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The Relationship Between Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor 2 Expression of Breast Cancer and the Retention Index in Dual Phase 18F-FDG PET/CT

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Abstract

Purpose

This study investigates the correlation of retention index (RI) using the dual phase FDG PET/CT scan with the breast cancer biomarkers.

Methods

A total of 55 patients with breast cancer underwent dual phase FDG PET/CT scans (60 and 120 min after FDG injection) before treatment. SUVmax and SUVmean of the primary breast tumors were measured, then the percent change of SUVmax and SUVmean between the two scans were calculated, and denoted as RImax and RImean, respectively. After the surgical resection of the breast tumor, the status of biomarkers (ER, PR, and HER-2) was evaluated in the postsurgical specimen.

Results

RImean was significantly higher in ER (−) (median, 16.2; IQR, 10.8–21.0) or HER-2 (+) (median, 16.1; IQR, 10.7–21.6) tumors than in ER (+) tumors (median, 9.9; IQR, 5.5–15.3) or HER-2 (−) tumors (median, 10.5; IQR, 5.5–16.1). However, there were no significant differences of SUVmax or RImax according to the ER or HER-2 status. There were no significant differences of any PET parameters between PR (+) and PR (−) tumors. Based off ROC curve analyses, RImean predicted the ER (+) tumors (AUC, 0.699; p = 0.006), and HER-2 (+) tumors (AUC, 0.674; p = 0.022), but not the PR (+) tumors. However, neither SUVmax nor RImax predicted ER (+), PR (+), or HER-2 (+) tumors.

Conclusions

Retention index of SUVmean can reflect the ER and HER-2 status of breast cancers. Higher retention index of SUVmean might associate with lower ER expression and higher HER-2 expression.

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Acknowledgments

This study was supported by the Establishment Center for PET Application Technology Development of the Korea Institute of Radiological and Medical Sciences (KIRAMS) and by a grant from the Ministry of Education, Science, and Technology (50441-2014).

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Authors and Affiliations

  1. Department of Nuclear Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), 75, Nowon-ro, Nowon-gu, Seoul, 139-706, Republic of Korea

    Hansol Moon, Joon Ho Choi, Kyung Woo Han, Byung Hyun Byun, Ilhan Lim, Byung Il Kim, Chang Woon Choi & Sang Moo Lim

  2. Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Republic of Korea

    Woo Chul Noh, Hyun-Ah Kim & Eun-Kyu Kim

  3. Department of Radiology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Republic of Korea

    Ko Woon Park

  4. National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Republic of Korea

    Seung Sook Lee

  5. Department of Pathology, Korea Cancer Center Hospital, Seoul, Republic of Korea

    Seung Sook Lee

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  1. Hansol Moon
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Correspondence to Sang Moo Lim.

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Conflict of Interest

Hansol Moon, Woo Chul Noh, Hyun-Ah Kim, Eun-Kyu Kim, Ko Woon Park, Seung Sook Lee, Joon Ho Choi, Kyung Woo Han, Byung Hyun Byun, Ilhan Lim, Byung Il Kim, Chang Woon Choi, and Sang Moo Lim declare that they have no conflict of interest.

Ethical Statement

This study was approved by the Institutional Review Board at Korea Cancer Center Hospital (IRB No.K-1412-002-009), and was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Acquisition of informed consent was exempted by the board because of the retrospective nature of the study. Details that might disclose the identity of the subjects was omitted. All authors declare that the submitted work and its essential substance have not previously been published and are not being considered for publication elsewhere.

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Moon, H., Noh, W.C., Kim, HA. et al. The Relationship Between Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor 2 Expression of Breast Cancer and the Retention Index in Dual Phase 18F-FDG PET/CT. Nucl Med Mol Imaging 50, 246–254 (2016). https://doi.org/10.1007/s13139-016-0412-2

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