Abstract
We report the case of a 16-year-old male patient presenting with several mass lesions on the left side of his neck that had been there for weeks. Whole-body 18F-fluorodeoxyglucose positron emission tomography and computed tomography (18F FDG PET-CT) revealed multiple focal areas of increased uptake of fluorodeoxyglucose (FDG) on the left side of the neck, left supraclavicular fossa, left axilla, and mediastinum, simulating the imaging findings of Hodgkin’s lymphoma. Subsequent incisional biopsy of lymph nodes in the left supraclavicular fossa with histologic examination confirmed the diagnosis of Kimura disease. The differential diagnoses should include Kimura disease when evaluating regional or generalized lymphadenopathy seen on 18F FDG PET-CT because it also may show prominent uptake of FDG.
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References
Kim HT, Szeto C. Eosinophilic hyperplastic lymphogranuloma: comparison with Mikulicz’s disease. Chin Med J. 1937;23:699–700.
Kimura T, Yoshimura S, Ishikawa E. Unusual granulation combined with hyperplastic changes of lymphatic tissue. Transl Soc Pathol Jpn. 1948;37:179–80.
Hoppe RT, Advani RH, Ai WZ, et al. Hodgkin lymphoma, version 2.2012 featured updates to the NCCN guidelines. J Natl Compr Cancer Netw. 2012;10:589–97.
Zelenetz AD, Abramson JS, Advani RH, et al. NCCN clinical practice guidelines in oncology: non-Hodgkin’s lymphomas. J Natl Compr Cancer Netw. 2010;8:288–334.
Li TJ, Kitano M. Oriental Kimura’s disease and its relation to angiolymphoid hyperplasia with eosinophilia (ALHE). S Pac Study. 1997;17:287–300.
Chen H, Thompson LD, Aguilera NS, et al. Kimura disease: a clinicopathologic study of 21 cases. Am J Surg Pathol. 2004;28:505–13.
Sun QF, Xu DZ, Pan SH, et al. Kimura disease: review of the literature. Intern Med J. 2008;38:668–72.
Wang DY, Mao JH, Zhang Y, et al. Kimura disease: a case report and review of the Chinese literature. Nephron Clin Pract. 2009;111:c55–61.
Natov SN, Strom JA, Ucci A. Relapsing nephrotic syndrome in a patient with Kimura’s disease and IgA glomerulonephritis. Nephrol Dial Transplant. 1998;13:2358–63.
Ohta N, Fukase S, Suzuki Y, et al. Increase of Th2 and Tc1 cells in patients with Kimura’s disease. Auris Nasus Larynx. 2011;38:77–82.
Katagiri K, Itami S, Hatano Y, et al. Invivo expression of IL-4, IL-5, IL-13 and IFN-gamma mRNAs in peripheral blood mononuclear cells and effect of cyclosporin A in a patient with Kimura’s disease. Br J Dermatol. 1997;137:972–7.
Kimura Y, Pawankar R, Aoki M, et al. Mast cells and T cells in Kimura’s disease express increased levels of interleukin-4, interleukin-5, eotaxin and RANTES. Clin Exp Allergy. 2002;32:1787–93.
Zhang R, Ban XH, Mo YX, et al. Kimura disease: the CT and MRI characteristics in fifteen cases. Eur J Radiol. 2011;80:489–97.
Park SW, Kim HJ, Sung KJ, et al. Kimura disease: CT and MR imaging findings. Am J Neuroradiol. 2012;33:784–8.
Li D, Li YJ, Zhan FH, et al. The false-positive finding of left pulmonary Kimura disease on 18F-FDG PET/CT. Clin Nucl Med. 2013;38:569–72.
Wang TF, Liu SH, Kao CH, et al. Kimura’s disease with generalized lymphadenopathy demonstrated by positron emission tomography scan. Intern Med. 2006;45:775–8.
Fadilah S-A-W, Shanty V, Goh AS. Kimura’s disease mimicking Hodgkin’s lymphoma: an unusual cause of parotid swelling. Med Health. 2007;2:99–102.
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Tsung-Han Yang, Yu-Hsiang Chou, Woei-Yau Kao, and Shiou-Chi Cherng declare that they have no conflict of interest.
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Yang, TH., Chou, YH., Kao, WY. et al. Kimura Disease Simulating Hodgkin’s Lymphoma on 18F FDG PET-CT: Report of a Case. Nucl Med Mol Imaging 48, 313–316 (2014). https://doi.org/10.1007/s13139-014-0285-1
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DOI: https://doi.org/10.1007/s13139-014-0285-1