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RETRACTED ARTICLE: Radiation Sialadenitis Induced by High-dose Radioactive Iodine Therapy

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This article was retracted on 15 February 2014

Abstract

Radioactive iodine (131I) is accumulated in the thyroid tissue and plays an important role in the treatment of differentiated papillary and follicular cancers after thyroidectomy. Simultaneously, 131I is concentrated in the salivary glands and secreted into the saliva. Dose-related damage to the salivary parenchyma results from the 131I irradiation. Salivary gland swelling and pain, usually involving the parotid, can be seen. The symptoms may develop immediately after a therapeutic dose of 131I and/or months later and progress in intensity with time. In conjunction with the radiation sialadenitis, secondary complications reported include xerostomia, taste alterations, infection, increases in caries, facial nerve involvement, candidiasis, and neoplasia. Prevention of 131I sialadenitis may involve the use of sialogogic agents to hasten the transit time of the radioactive iodine through the salivary glands. However, studies are not available to delineate the efficacy of this approach. Treatment of the varied complications that may develop encompass numerous approaches and include gland massage, sialogogic agents, duct probing, antibiotics, mouthwashes, good oral hygiene, and adequate hydration. Recently interventional sialoendoscopy has been introduced an effective tool for the management of patients with 131I-induced sialadenitis that is unresponsive to medical treatment.

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Acknowledgement

This work was supported by Nuclear Research & Development Program of National Research Foundation of Korea(NRF) funded by Ministry of Education, Science & Technology(MEST) (Grant code : 2009-0078234) and Brain Korea 21 Project from Ministry of Education, Science and Technology, Republic of Korea in 2009.

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Correspondence to Jaetae Lee.

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The senior author (J. Lee) and the first author (S. Y. Jeong) have retracted this review article due to misconduct. They have discovered multiple instances of misreferencing and misquotation in the text which raise the concern of potential plagiarism.

An erratum to this article is available at http://dx.doi.org/10.1007/s13139-014-0268-2.

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Jeong, S.Y., Lee, J. RETRACTED ARTICLE: Radiation Sialadenitis Induced by High-dose Radioactive Iodine Therapy. Nucl Med Mol Imaging 44, 102–109 (2010). https://doi.org/10.1007/s13139-010-0027-y

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