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Recent Trends in the Nucleophilic [18F]-radiolabeling Method with No-carrier-added [18F]fluoride

Nuclear Medicine and Molecular Imaging volume 44, pages 25–32 (2010)Cite this article

Abstract

Noninvasive imaging in living subjects with positron emission tomography (PET) provides early detection of diseases in humans. For this application, it is necessary to prepare specific molecular imaging probes labeled with positron-emitting radioisotopes such as fluorine-18 for obtaining high-quality PET imaging. In this review, we describe recent trends in the F-18 radiolabeling method for the introduction of no-carrier-added fluorine-18, which was obtained from an 18O(p,n)18F reaction, into a specific molecular site, which in turn is intended to serve as an imaging agent for PET study. These labeling protocols are based on ionic liquid media 18F radiofluorination in the presence of some water, enzymatic 18F fluorination using fluorinase in water solution, non-polar protic alcohol media 18F radiofluorination and its mechanism, and nucleophilic 18F fluorination of an aromatic iodonium salt precursor.

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Acknowledgment

This work was supported by Nuclear Research and Development Program of the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MEST) (grant code: 2009-0078422 and 2009-0062472 to D.W.K). We also thank Dr. Vinod H. Jadhav for helpful discussions.

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Affiliations

  1. Department of Nuclear Medicine, Cyclotron Research Center, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk, 561-712, Korea

    Dong Wook Kim, Hwan-Jeong Jeong, Seok Tae Lim & Myung-Hee Sohn

  2. Department of Nuclear Medicine, Cyclotron Research Center, Chonbuk National University Medical School, Jeonju, Jeonbuk, 561-712, Korea

    Dong Wook Kim

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  1. Dong Wook Kim
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  2. Hwan-Jeong Jeong
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Correspondence to Dong Wook Kim.

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Kim, D.W., Jeong, HJ., Lim, S.T. et al. Recent Trends in the Nucleophilic [18F]-radiolabeling Method with No-carrier-added [18F]fluoride. Nucl Med Mol Imaging 44, 25–32 (2010). https://doi.org/10.1007/s13139-009-0008-1

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  • DOI: https://doi.org/10.1007/s13139-009-0008-1

Keywords

  • Nucleophilic fluorination
  • Fluorine-18
  • Ionic liquid
  • Tert alcohol
  • Fluorinase
  • Iodonium salts