Abstract
Aim-Background
Treatment of abdominal aortic aneurysms remains a challenging task. We examined the effects of n-acetylcysteine and desferoxamine on interleukin-6, tumour necrosis factor-a, and oxidized low density lipoprotein after infrarenal aortic clamping.
Methods
Fifteen piglets were assigned to three groups. The control group (Group C) received saline as placebo (10-mL dilution, bolus), whereas the Group of n-acetylcysteine (Group NAC) received 150mg/kg IV n-acetylcysteine 30 min prior to aortic clamping and 50mg/kg/h after its release (reperfusion). The desferoxamine group (Group D) received IM 100mg/kg/d desferoxamine for 3 days prior to the experiment.
Results
Interleukin-6 increased significantly one hour after aortic clamping, while administration of desferoxamine and n-acetylcysteine had no effect on its production. Tumour necrosis factor-a increased after aortic clamping and failed to normalise during the experiment in all groups. At 2 hours post-reperfusion, desferoxamine had a modest effect on tumour necrosis factor-a values, while in Group NAC, tumour necrosis factor-a had decreased by 50% at 10 min post-reperfusion. Oxidized low density lipoprotein in Group C did not increase significantly from baselines values. In Groups D and NAC, oxidized low density lipoprotein had increased at 10 min post-reperfusion, after which it progressively decreased until 2 hours post-reperfusion.
Conclusions
Interleukin-6 and tumour necrosis factor-a increased significantly after aortic clamping. Administration of desferoxamine and n-acetylcysteine had no effect on interleukin-6, while administration of n-acetylcysteine reduced tumour necrosis factor-a by 50% at 10 min post-reperfusion. Although in Groups D and NAC oxidized low density lipoprotein increased post-reperfusion, it progressively decreased with time.
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Katseni, K., Chalkias, A., Kaparos, G. et al. The effects of n-acetylcysteine and desferoxamine on IL-6, TNF-a, and oxLDL after infrarenal aortic clamping. Hellenic J Surg 87, 407–414 (2015). https://doi.org/10.1007/s13126-015-0247-9
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DOI: https://doi.org/10.1007/s13126-015-0247-9