Abstract
Aim-Background
With less than 100 cases reported in the English literature to date, Warthin-like tumour papillary thyroid carcinoma is a relatively uncommon variant of papillary thyroid carcinoma (PTC). This term was first coined on the basis of its close morphological resemblance to the Warthin tumour that characteristically occurs in the salivary glands.We present a case of this uncommon variety of PTC, and through a brief literature review we describe the diagnostic challenges presented in distinguishing between several varieties of PTC and benign lesions to provide optimal treatment.
Case Report
A 48-year-old woman was referred to our department for surgical treatment of an enlarged goitre that had presented over the last year. Dominant nodule FNA revealed suspicion of a follicular neoplasm, and she was submitted to total thyroidectomy.
Results
Histopathology showed multifocal PTC on chronic lymphocytic thyroiditis ground. Left lobe foci of 0.3 cm follicular variant of PTC, 0.6 cm isthmus foci of Warthin-like tumour PTC and 1.5 cm of conventional PTC with extrathyroidal extension were reported.
Conclusion/Discussion
Previous studies showed prognosis to be similar to that for conventional PTC. Distinction between Hurthle cell tumours, tall cell and oncocytic variants of PTC or medullary carcinoma, or even lymphocytic thyroiditis and this entity, is intriguing and poses diagnostic difficulties. Data from new studies will reveal more on this uncommon tumour.
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References
R. L. Apel, S. L. Asa, and V. A. LiVolsi, “Papillary Hurthle cell carcinoma with lymphocytic stroma: “Warthin-like tumor” of the thyroid,” American Journal of Surgical Pathology, 1995; vol. 19, no. 7, pp. 810–814.
Panagiotis Paliogiannis, Federico Attene, Federica Trogu, and Mario Trignano, “Warthin-Like Papillary Carcinoma of the Thyroid Gland: Case Report and Review of the Literature”, Case Reports in Oncological Medicine Volume 2012
H. H. Kim, D. Myssiorek, K. S. Heller, F. Zahurullah, and T. Bhuiya, “Warthin-like tumor of the thyroid gland: an uncommon variant of papillary thyroid cancer,” Ear, Nose and Throat Journal, 2006; vol. 85, no. 1, pp. 56–59.
K. Tazawa, S. Umemura, H. Kajiwara et al., “Cytologic features of papillary carcinomas of the thyroid gland associated with chronic thyroiditis-4 cases report,” The Journal of the Japanese Society of Clinical Cytology, 1999’ vol. 38, pp. 281–286.
A. D’Antonio, A. De Chiara, M. Santoro, G. Chiappetta, and N. S. Losito, “Warthin-like tumour of the thyroid gland: RET/PTC expression indicates it is a variant of papillary carcinoma,” Histopathology, 2000; vol. 36, no. 6, pp. 493–498.
E. Sarkady, Z. Sapi, V. Toth, and S. Kiss, “Warthin-like tumor of the thyroid: a case report,” Pathology and Oncology Research, 1999; vol. 5, no. 4, pp. 315–317.
M. Ludvikova, A. Ryska, M. Korabecna, M. Rydlova, and M. Michal, “Oncocytic papillary carcinoma with lymphoid stroma (Warthin-like tumour) of the thyroid: a distinct entity with favourable prognosis,” Histopathology, 2001; vol. 39, no. 1, pp. 17–24.
T. Bocklage, J. P. DiTomasso, I. Ramzy, and M. L. Ostrowski, “Tall cell variant of papillary thyroid carcinoma: cytologic features and differential diagnostic considerations,” Diagnostic Cytopathology, 1999; vol. 17, pp. 25–29.
M. L. Ostrowski and M. J. Merino, “Tall cell variant of papillary thyroid carcinoma: a reassessment and immunohistochemical study with comparison to the usual type of papillary carcinoma of the thyroid,” American Journal of Surgical Pathology, 1996; vol. 20, no. 8, pp. 964–974.
F. J. Vera-Sempere, M. Prieto, and A. Camanas, “Warthin-like tumor of the thyroid: a papillary carcinoma with mitochondrionrich cells and abundant lymphoid stroma. A case report,” Pathology Research and Practice, 1998; vol. 194, no. 5, pp. 341–347.
Z. W. Baloch and V. A. LiVolsi, “Warthin-like papillary carcinoma of the thyroid”, Archives of Pathology and Laboratory Medicine, 2000; vol. 124, no. 8, pp. 1192–1195.
P. Amico, S. Lanzafame, G. Li Destri et al., “Warthin tumor like papillary thyroid carcinoma with a minor dedifferentiated component: report of a case with clinicopathologic considerations”, Journal of Medical Case Reports, vol. 2010; Article ID 495281, 5 pages.
K. Y. Lam, C. Y. Lo, and W. I. Wei, “Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and aggressive biological behaviour,” Endocrine Pathology, 2005; vol. 16, no. 1, pp. 83–89.
Makoto Urano, Masato Abe, Makoto Kuroda, Yoshikazu Mizoguchi, Yoshimune Horibe, Masao Kasahara, Koichi Tanaka, Kensuke Sudo and Yutaka Hirasawa, “Warthin-like tumor variant of papillary thyroid carcinoma: Case report and literature review”, Pathology International 2001; 51: 707–712
Nuray Can, Fulya Öz Puyan, Feriha Öz, Filiz Özyilmaz, Semsi Altaner, Zeynep Pehlivanoglu, A. Kemal Kutlu, “Warthin-like papillary thyroid carcinoma: A rare tumor of the thyroid”, Dicle Med J / Vol 38, No 4, 482–485/ 2011; 38 (4): 482–485
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Christoforides, C., Panaretou, C., Christodoulou, Z. et al. Warthin-like tumour papillary thyroid carcinoma. Hellenic J Surg 85, 197–201 (2013). https://doi.org/10.1007/s13126-013-0037-1
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DOI: https://doi.org/10.1007/s13126-013-0037-1