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Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet

Journal of Physiology and Biochemistry volume 69, pages 677–686 (2013)Cite this article

Abstract

Fetuin-A is synthesized in the liver and is secreted into the bloodstream. Clinical studies suggest involvement of fetuin-A in metabolic disorders such as visceral obesity, insulin resistance, diabetes, and fatty liver. Curcumin is extracted from the rhizome Curcuma longa and has been shown to possess potent antioxidant, anticarcinogenic, anti-inflammatory, and hypoglycemic properties. In this study, we investigated the effect of curcumin treatment on serum fetuin-A levels as well as hepatic lipids and prooxidant–antioxidant status in rats fed a high-fat diet (HFD). Male Sprague–Dawley rats were divided into six groups. Group 1 was fed control diet (10 % of total calories from fat). Groups 2 and 3 were given curcumin (100 and 400 mg/kg bw/day, respectively ) by gavage for 8 weeks and were fed control diet. Group 4 was fed with HFD (60 % of total calories from fat). Groups 5 and 6 received HFD together with the two doses of curcumin, respectively. Curcumin treatment appeared to be effective in reducing liver triglycerides and serum fetuin-A levels. These findings suggest that the reduction of fetuin-A may contribute to the beneficial effects of curcumin in the pathogenesis of obesity.

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Acknowledgments

This work was supported by the Research Fund of Istanbul University. Project number 8244.

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Affiliations

  1. Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, Istanbul, Turkey

    Yildiz Öner-İyidoğan, Muhammed Seyidhanoğlu, Figen Gürdöl & Müjdat Uysal

  2. Department of Biochemistry, Faculty of Medicine, Istanbul Bilim University, Esentepe, Istanbul, Turkey

    Hikmet Koçak

  3. Department of Pathology, Faculty of Veterinary Medicine, Istanbul University, Avcilar, Istanbul, Turkey

    Ahmet Gülçubuk & Funda Yildirim

  4. Department of Laboratory Animal Biology and Applied Biomedical Techniques, Institute for Experimental Research and Applied Medical Research, Istanbul University, Çapa, Istanbul, Turkey

    Aydin Çevik

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  1. Yildiz Öner-İyidoğan
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  2. Hikmet Koçak
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Correspondence to Yildiz Öner-İyidoğan.

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Öner-İyidoğan, Y., Koçak, H., Seyidhanoğlu, M. et al. Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet. J Physiol Biochem 69, 677–686 (2013). https://doi.org/10.1007/s13105-013-0244-9

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Keywords

  • Obesity
  • Curcumin
  • Fetuin-A
  • Fatty liver
  • High-fat diet