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Antihyperglycemic, hypolipidemic and antioxidant activities of ethanolic extract of Commiphora mukul gum resin in fructose-fed male Wistar rats


High fructose feeding (66 % of fructose) induces type-2 diabetes in rats, which is associated with the insulin resistance, hyperinsulinemia, hypertriglyceridemia and oxidative stress. The present study was undertaken to evaluate the effect of ethanol extract of Commiphora mukul gum resin (CMEE) on blood glucose, plasma insulin, lipid profiles, reduced glutathione, lipid peroxidation, protein oxidation and enzymatic antioxidants like superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, glutathione-S-transferase in fructose-induced type-2 diabetic rats. A significant gain in body weight, hyperglycemia, hyperinsulinemia, increased lipid profiles, lipid peroxidation, protein oxidation and decreased reduced glutathione, activities of enzymatic antioxidants and insulin sensitivity (increased homeostasis assessment assay) were observed in high-fructose-induced diabetic rats. The administration of CMEE (200 mg/kg/day) daily for 60 days in high-fructose-induced diabetic rats reversed the above parameters significantly. CMEE has the ability to improve insulin sensitivity and delay the development of insulin resistance, aggravate antioxidant status in diabetic rats and may be used as an adjuvant therapy for patients with insulin resistance.

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Fig. 1
Fig. 2
Fig. 3





Ethanolic extract of Commiphora mukul




Control + Commiphora mukul ethanol extract


Free fatty acids




Fructose + Commiphora mukul ethanol extract


Glutathione peroxidase


Glutathione reductase


Reduced glutathione




Homeostasis model assessment


Insulin resistance


Lipid peroxidation


Non-insulin-dependent diabetes mellitus


Protein oxidation


Reactive oxygen species


Superoxide dismutase


Thiobarbituric-acid-reactive substances


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We thank Prof. Ch. Appa Rao, Dr. E.G.T.V. Kumar and Dr. K. Ramesh Babu, Sri Venkateswara University, Tirupati, for their help with the insulin assay.

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The authors declare that they have no conflicts of interest.

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Correspondence to D. Saralakumari.

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Ramesh, B., Saralakumari, D. Antihyperglycemic, hypolipidemic and antioxidant activities of ethanolic extract of Commiphora mukul gum resin in fructose-fed male Wistar rats. J Physiol Biochem 68, 573–582 (2012).

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  • Commiphora mukul
  • Insulin resistance
  • High fructose diet
  • Hypertriglyceridemia
  • Hyperinsulinemia
  • Antioxidant