Skip to main content
Log in

Sorcin, a potential therapeutic target for reversing multidrug resistance in cancer

  • Mini Review
  • Published:
Journal of Physiology and Biochemistry Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Anthony DF, Beattie J, Paul A, Currie S (2007) Interaction of calcium/calmodulin-dependent protein kinase IIδC with sorcin indirectly modulates ryanodine receptor function in cardiac myocytes. J Mol Cell Cardiol 43:492–503

    Article  PubMed  CAS  Google Scholar 

  2. Beyer-Sehlmeyer G, Hiddemann W, WÖrmann B, Bertram J (1999) Suppressive subtractive hybridisation reveals differential expression of serglycin, sorcin, bone marrow proteoglycan and prostate-tumour-inducing gene I (PTI-1) in drug-resistant and sensitive tumour cell lines of haematopoetic origin. Eur J Cancer 35:1735–1742

    Article  PubMed  CAS  Google Scholar 

  3. Brownawell AM, Creutz CE (1997) Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII). J Biol Chem 272:22182–22190

    Article  PubMed  CAS  Google Scholar 

  4. Chuthapisith S, Bean BE, Cowley G, Eremin JM, Samphao S, Layfield R et al (2009) Annexins in human breast cancer: possible predictors of pathological response to neoadjuvant chemotherapy. Eur J Cancer 45:1274–1281

    Article  PubMed  CAS  Google Scholar 

  5. Chuthapisith S, Layfield R, Kerr ID, Hughes C, Eremin O (2007) Proteomic profiling of MCF-7 breast cancer cells with chemoresistance to different types of anti-cancer drugs. Int J Oncol 30:1545–1551

    PubMed  CAS  Google Scholar 

  6. Colotti G, Zamparelli C, Verzili D, Mella M, Loughrey CM, Smith GL, Chiancone E (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry 45:12519–12529

    Article  PubMed  CAS  Google Scholar 

  7. Deng L, Su T, Leng A, Zhang X, Xu M, Yan L, Gu H, Zhang G (2010) Upregulation of soluble resistance-related calcium-binding protein (sorcin) in gastric cancer. Med Oncol 27:1102–1108

    Article  PubMed  CAS  Google Scholar 

  8. Fowler MR, Colotti G, Chiancone E, Higuchi Y, Seidler T, Smith GL (2009) Complex modulation of L-type Ca2+ current inactivation by sorcin in isolated rabbit cardiomyocytes. Eur J Physiol 457:1049–1060

    Article  CAS  Google Scholar 

  9. Fowler MR, Colotti G, Chiancone E, Smith GL, Fearon IM (2008) Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the α1C subunit in rabbits. Exp Physiol 93:1233–1238

    Article  PubMed  CAS  Google Scholar 

  10. Hall MD, Handley MD, Gottesman MM (2009) Is resistance useless? Multidrug resistance and collateral sensitivity. Trends Pharmacol Sci 30:546–556

    Article  PubMed  CAS  Google Scholar 

  11. Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (2003) The PEF family proteins sorcin and grancalcin interact in vivo and in vitro. FEBS Lett 545:151–154

    Article  PubMed  CAS  Google Scholar 

  12. He Q, Zhang G, Hou D, Leng A, Xu M, Peng J, Liu T (2011) Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp. Oncol Rep 25:237–243

    PubMed  CAS  Google Scholar 

  13. Ilari A, Johnson KA, Nastopoulos V, Verzili D, Zamparelli C, Colotti G, Tsernoglou D, Chiancone E (2002) The crystal structure of the sorcin calcium binding domain provides a model of Ca2+-dependent processes in the full-length protein. J Mol Biol 317:447–458

    Article  PubMed  CAS  Google Scholar 

  14. Jin JH, Hulette C, Wang Y, Zhang T, Pan C, Wadhwa R, Zhang J (2006) Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease. Mol Cell Proteomics 5:1193–1204

    Article  PubMed  CAS  Google Scholar 

  15. Kawakami M, Nakamura T, Okamura N, Komoto C, Markova S, Kobayashi H et al (2007) Knock-down of sorcin induces up-regulation of MDR1 in HeLa cells. Biol Pharm Bull 30:1065–1073

    Article  PubMed  CAS  Google Scholar 

  16. Kobayashi T, Yamada Y, Fukao M, Tsutsuura M, Tohse N (2007) Regulation of CaV1.2 Current: interaction with intracellular molecules. J Pharmacol Sci 103:347–353

    Article  PubMed  CAS  Google Scholar 

  17. Koch G, Smith M, Twentyman P, Wright K (1986) Identification of a novel calcium-binding protein (CP22) in multidrug-resistant murine and hamster cells. FEBS Lett 195:275–279

    Article  PubMed  CAS  Google Scholar 

  18. Landriscina M, Laudiero G, Maddalena F, Amoroso MR, Piscazzi A, Cozzolino F, Monti M, Garbi C, Fersini A, Pucci P, Esposito F (2010) Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents. Cancer Res 70:6577–6586

    Article  PubMed  CAS  Google Scholar 

  19. Li J, Chen BA, Zhu MS, Gao F, Ding JH, Gao C et al (2008) Influence of tetrandrine on SORCIN gene expression in K562/A02 cell line. Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:65–69

    PubMed  Google Scholar 

  20. Lollike K, Johnsen AH, Durussel I, Borregaard N, Cox JA (2001) Biochemical characterization of the Penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. J Biol Chem 276:17762–17769

    Article  PubMed  CAS  Google Scholar 

  21. Maki M, Kitaura Y, Satoh H, Ohkouchi S, Shibata H (2002) Structures, functions and molecular evolution of the penta-EF-hand Ca2+-binding proteins. Biochim Biophys Acta 1600:51–60

    Article  PubMed  CAS  Google Scholar 

  22. Margetis P, Antonelou M, Karababa F, Loutradi A, Margaritis L, Papassideri I (2007) Physiologically important secondary modifications of red cell membrane in hereditary spherocytosis-evidence for in vivo oxidation and lipid rafts protein variations. Blood Cell Mol Dis 38:210–220

    Article  CAS  Google Scholar 

  23. Martinsson T, Dahllöf B, Wettergren Y, Leffler H, Levan G (1985) Pleiotropic drug resistance and gene amplification in a SEWA mouse tumor cell line. Complex relations revealed by drug uptake data, and lipid and protein analysis. Exp Cell Res 158:382–394

    Article  PubMed  CAS  Google Scholar 

  24. Meyers MB, Biedler JL (1981) Increased synthesis of a low molecular weight protein in vincristine-resistant cells. Biochem Biophys Res Commun 99:228–235

    Article  PubMed  CAS  Google Scholar 

  25. Meyers MB, Spengler BA, Chang TD, Melera PW, Biedler JL (1985) Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells. J Cell Biol 100:588–597

    Article  PubMed  CAS  Google Scholar 

  26. Okamoto Y, Chaves A, Chen J, Kelley R, Jones K, Weed HG et al (2001) Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction. Am J Pathol 159:639–650

    Article  PubMed  CAS  Google Scholar 

  27. Pack-Chung E, Meyers MB, Pettingell WP, Moir RD, Brownawell AM, Cheng I et al (2000) Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor. J Biol Chem 275:14440–14445

    Article  PubMed  CAS  Google Scholar 

  28. Parekh HK, Deng HB, Choudhary K, Houser SR, Simpkins H (2002) Overexpression of sorcin, a calcium-binding protein, induces a low level of paclitaxel resistance in human ovarian and breast cancer cells. Biochem Pharmacol 63:1149–1158

    Article  PubMed  CAS  Google Scholar 

  29. Qi J, Liu N, Zhou Y, Tan Y, Cheng Y, Yang C, Zhu Z, Xiong D (2006) Overexpression of sorcin in multidrug resistant human leukemia cells and its role in regulating cell apoptosis. Biochem Biophys Res Commun 349:303–309

    Article  PubMed  CAS  Google Scholar 

  30. Qu Y, Yang Y, Liu B, Xiao W (2010) Comparative proteomic profiling identified sorcin being associated with gemcitabine resistance in non-small cell lung cancer. Med Oncol 27:1303–1308

    Article  PubMed  CAS  Google Scholar 

  31. Rueda A, Song M, Toro L, Stefani E, Valdivia HH (2006) Sorcin modulation of Ca2+ sparks in rat vascular smooth muscle cells. J Physiol 576:887–901

    Article  PubMed  CAS  Google Scholar 

  32. Salzer U, Hinterdorfer P, Hunger U, Borken C, Prohaska R (2002) Ca(++)-dependent vesicle release from erythrocytes lipid rafts, synexin (annexin VII), and sorcin. Blood 99:2569–2577

    Article  PubMed  CAS  Google Scholar 

  33. Szakács G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM (2006) Targeting multidrug resistance in cancer. Nat Rev Drug Discov 5:219–234

    Article  PubMed  Google Scholar 

  34. Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y et al (2005) Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. FASEB J 19:2069–2071

    PubMed  CAS  Google Scholar 

  35. Tan Y, Li G, Zhao C, Wang J, Zhao H, Xue Y, Han M, Yang C (2003) Expression of sorcin predicts poor outcome in acute myeloid leukemia. Leukemia Res 27:125–131

    Article  CAS  Google Scholar 

  36. Tripodi D, Quéméner S, Renaudin K, Ferron C, Malard O, Guisle-Marsollier I et al (2009) Gene expression profiling in sinonasal adenocarcinoma. BMC Med Genomics 2:65

    Article  PubMed  Google Scholar 

  37. Twentyman PR, Reeve JG, Koch G, Wright KA (1990) Chemosensitisation by verapamil and cyclosporin A in mouse tumour cells expressing different levels of P-glycoprotein and CP22 (sorcin). Br J Cancer 62:89–95

    Article  PubMed  CAS  Google Scholar 

  38. Valdivia HH (1998) Modulation of intracellular Ca2+ levels in the heart by sorcin and FKBP12, two accessory proteins of ryanodine receptors. Trends Pharmacol Sci 19:479–482

    Article  PubMed  CAS  Google Scholar 

  39. Valkova N, Yunis R, Mak SK, Kang K, Kültz D (2005) Nek8 mutation causes overexpression of aalectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck Mice. Mol Cell Proteomics 4:1009–1018

    Article  PubMed  CAS  Google Scholar 

  40. Van der Blick AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF et al (1988) Genes amplified and overexpressed in human multidrug-resistant cell lines. Cancer Res 48:5927–5932

    Google Scholar 

  41. Van der Bliek AM, Meyers MB, Biedler JL, Hes E, Borst P (1986) A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain. EMBO J 5:3201–3208

    PubMed  Google Scholar 

  42. Verzili D, Zamparelli C, Mattei B, Noegel AA, Chiancone E (2000) The sorcin-annexin VII calcium-dependent interaction requires the sorcin N-terminal domain. FEBS Lett 471:197–200

    Article  PubMed  CAS  Google Scholar 

  43. Wang SL, Tam MF, Ho YS, Pai SH, Kao MC (1995) Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells. Biochim Biophys Acta 1260:285–293

    Article  PubMed  Google Scholar 

  44. Werner CJ, Heyny-von Haussen R, Mall G, Wolf S (2008) Proteome analysis of human substantia nigra in Parkinson’s disease. Proteome Sci 6:8

    Article  PubMed  Google Scholar 

  45. Wilkinson DK, Turner EJ, Parkin ET, Garner AE, Harrison PJ, Crawford M, Stewart GW, Hooper NM (2008) Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis. Biochim Biophys Acta 1778:125–132

    Article  PubMed  CAS  Google Scholar 

  46. Witkowski JM, Miller RA (1999) Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein. Mech Ageing Dev 107:165–180

    Article  PubMed  CAS  Google Scholar 

  47. Xie XL, Dwyer MD, Swenson L, Parker MH, Botfield MC (2001) Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family. Protein Sci 10:2419–2425

    Article  PubMed  CAS  Google Scholar 

  48. Yang YX, Chen ZC, Zhang GY, Yi H, Xiao ZQ (2008) A subcelluar proteomic investigation into vincristine-resistant gastric cancer cell line. J Cell Biochem 104:1010–1021

    Article  PubMed  CAS  Google Scholar 

  49. Yang YX, Xiao ZQ, Chen ZC, Zhang GY, Yi H, Zhang PF, Li JL, Zhu G (2006) Proteome analysis of multidrug resistance in vincristine-resistant human gastric cancer cell line SGC7901/VCR. Proteomics 6:2009–2021

    Article  PubMed  CAS  Google Scholar 

  50. Zamparelli C, Ilari A, Verzili D, Vecchini P, Chiancone E (1997) Calcium- and pH-linked oligomerization of sorcin causing translocation from cytosol to membranes. FEBS Lett 409:1–6

    Article  PubMed  CAS  Google Scholar 

  51. Zhou Y, Xu Y, Tan Y, Qi J, Xiao Y, Yang C, Zhu Z, Xiong D (2006) Sorcin, an important gene associated with multidrug-resistance in human leukemia cells. Leukemia Res 30:469–476

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work was funded by the Natural Science Foundation of China Grants (30973548) and Shandong Province Outstanding Young Scientists Research Award Fund Project (BS2010SW020).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Xiu-Li Guo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zheng, BB., Zhang, P., Jia, WW. et al. Sorcin, a potential therapeutic target for reversing multidrug resistance in cancer. J Physiol Biochem 68, 281–287 (2012). https://doi.org/10.1007/s13105-011-0140-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13105-011-0140-0

Keywords

Navigation