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Dietary n-3 polyunsaturated fatty acids modify fatty acid composition in hepatic and abdominal adipose tissue of sucrose-induced obese rats

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Abstract

The fatty acid profile of hepatocytes and adipocytes is determined by the composition of the dietary lipids. It remains unclear which fatty acid components contribute to the development or reduction of insulin resistance. The present work examined the fatty acid composition of both tissues in sucrose-induced obese rats receiving fish oil to determine whether the effect of dietary (n-3) polyunsaturated fatty acids (PUFAs) on the reversion of metabolic syndrome in these rats is associated to changes in the fatty acid composition of hepatocyte and adipocyte membrane lipids. Animals with metabolic syndrome were divided into a corn–canola oil diet group and a fish oil diet group, and tissues fatty acids composition were analyzed after 6 weeks of dietary treatment. Fatty acid profiles of the total membrane lipids were modified by the fatty acid composition of the diets fed to rats. N-3 PUFAs levels in animals receiving the fish oil diet plus sucrose in drinking water were significantly higher than in animals under corn–canola oil diets. It is concluded that in sucrose-induced obese rats, consumption of dietary fish oil had beneficial effects on the metabolic syndrome and that such effects would be conditioned by the changes in the n-3 PUFAs composition in hepatic and adipose tissues because they alter membrane properties and modify the type of substrates available for the production of active lipid metabolites acting on insulin resistance and obesity.

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Acknowledgments

This work was supported by grant 362.06-P from the General Direction of Superior Technological Studies (DGEST-SEP).

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Authors and Affiliations

  1. Facultad de Bioanálisis, Universidad Veracruzana, Escuela de Medicina, Universidad Cristóbal Colón, Veracruz, Veracruz, Mexico

    Alfonso Alexander-Aguilera

  2. Instituto Tecnológico de Veracruz, UNIDA, M.A. de Quevedo 2779, Col. Formando Hogar, Veracruz, Veracruz, 91897, Mexico

    Silvia Berruezo, Guillermo Hernández-Diaz, Ofelia Angulo & Rosamaria Oliart-Ros

Authors
  1. Alfonso Alexander-Aguilera
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  2. Silvia Berruezo
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  3. Guillermo Hernández-Diaz
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  4. Ofelia Angulo
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  5. Rosamaria Oliart-Ros
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Correspondence to Rosamaria Oliart-Ros.

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Alexander-Aguilera, A., Berruezo, S., Hernández-Diaz, G. et al. Dietary n-3 polyunsaturated fatty acids modify fatty acid composition in hepatic and abdominal adipose tissue of sucrose-induced obese rats. J Physiol Biochem 67, 595–604 (2011). https://doi.org/10.1007/s13105-011-0106-2

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  • DOI: https://doi.org/10.1007/s13105-011-0106-2

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