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Leptin increases prostate cancer aggressiveness

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Abstract

Recent studies indicate that adipose tissue and adipocytokines might affect the development of prostate cancer (PCa). Leptin would have a stimulating effect on prostate cancer cells by inducing promotion and progression, whereas adiponectin would have a protective effect. The aim of this study was to determine the relation between body composition, leptin, and adiponectin levels with the prevalence and aggressiveness of PCa in men of Mendoza, Argentina. Seventy volunteers between 50 and 80 years (35 healthy men as control group and 35 with PCa) were selected. The PCa group was subclassified according to the Gleason Score (GS). Digital rectal examination, transrectal ultrasound, and prostatic biopsy were performed; PSA, testosterone, leptin, and adiponectin levels were determined; and a nutritional interview including anthropometric measurements and a food frequency questionnaire was carried out. Statistical analysis was performed by Student t test, ANOVA I, and Bonferroni (p < 0.05). Body mass index and percentage of body fat mass were not statistically different between PCa and control groups. However, body fat mass was higher in subjects with more aggressive tumors (p = 0.032). No differences were observed regarding leptin levels between the groups. Nevertheless, leptin levels were higher in subjects with high GS (p < 0.001). Adiponectin levels showed no statistical differences regarding the presence and aggressiveness of the tumor (p = 0.131). Finally, consumption and nutrient intake did not differ in the studied groups. In conclusion, body composition and leptin are related to the PCa aggressiveness but not with its prevalence.

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Acknowledgments

We are deeply indebted to Diego Messina, Cristina Vanrell, and Gabriela Recalde for their excellent technical assistance. The research was financially supported in part by Universidad Juan Agustin Maza and by Fundación Allende.

Conflicts of interest

None of the contributing authors has any conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript.

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Authors and Affiliations

  1. Laboratorio de Enfermedades Metabólicas y Cáncer, Facultad de Farmacia y Bioquímica, Universidad Juan Agustín Maza, Acceso Este Lateral Sur 2256, Guaymallén, Mendoza, CP 5519, Argentina

    Constanza M. López Fontana, María E. Maselli, Rafael F. Pérez Elizalde, Nicolás A. Di Milta Mónaco, Ana L. Uvilla Recupero & José D. López Laur

  2. Laboratorio de Hormonas y Biología del Cáncer, IMBECU, CONICET CCT, Mendoza, Argentina

    Constanza M. López Fontana & María E. Maselli

  3. Laboratorio de Alta Complejidad Pérez Elizalde, Mendoza, Argentina

    Rafael F. Pérez Elizalde

  4. Área Urología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina

    José D. López Laur

Authors
  1. Constanza M. López Fontana
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  2. María E. Maselli
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  5. Ana L. Uvilla Recupero
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Correspondence to Constanza M. López Fontana.

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López Fontana, C.M., Maselli, M.E., Pérez Elizalde, R.F. et al. Leptin increases prostate cancer aggressiveness. J Physiol Biochem 67, 531–538 (2011). https://doi.org/10.1007/s13105-011-0098-y

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  • DOI: https://doi.org/10.1007/s13105-011-0098-y

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