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Journal of Physiology and Biochemistry

, Volume 67, Issue 1, pp 121–128 | Cite as

Inhibitory effects of estrogens on digestive enzymes, insulin deficiency, and pancreas toxicity in diabetic rats

  • Khaled HamdenEmail author
  • Bassem Jaouadi
  • Nedia Zaraî
  • Tarek Rebai
  • Serge Carreau
  • Abdelfattah Elfeki
Original Paper

Abstract

Diabetes mellitus, with its attendant disorders and dysfunctional behaviors, constitutes a growing concern to the population of the world. With this concern in mind, the present study investigated the anti-diabetic and hypolipedimic potential of 17β-estradiol (called E2), particularly in terms of its inhibitory effects on maltase, sucrase, lactase, and lipase activities in the intestine of surviving diabetic rats. The findings revealed that this supplement helped protect the β cells of the rats from death and damage. Interestingly, E2 induced considerable decreases of 29%, 46%, 42%, and 84% in the activities of intestinal maltase, lactase, sucrase, and lipase, respectively. The E2 extract also decreased the glucose, triglyceride, and total cholesterol rates in the plasma of diabetic rats by 39%, 27%, and 53%, respectively, and increased the HDL–cholesterol level by 74%, which helped maintain the homeostasis of blood lipid. When compared to those of the untreated diabetic rats, the superoxide dismutase, catalase, and glutathione peroxidase levels in the pancreas of the rats treated with this supplement were also enhanced by 330%, 170%, and 301%, respectively. A significant decrease was also observed in the lipid peroxidation level and lactate dehydrogenase activity in the pancreas of diabetic rats after E2 administration. Overall, the findings presented in this study demonstrate that E2 has both a promising potential with regard to the inhibition of intestinal maltase, sucrase, lactase, and lipase activities, and a valuable hypoglycemic and hypolipidemic function, which make it a potential strong candidate for industrial application as apharmacological agent for the treatment and prevention of hyperlipidemia, obesity, and cardiovascular diseases.

Keywords

Disaccharidases Lipase Intestine Estrogens Diabetes Pancreas 

Notes

Acknowledgments

This research was supported by the Tunisian Ministry of Higher Education and Scientific Research and Technology and the Tunisian Ministry of Public Health. The authors wish to express their sincere gratitude to Prof. Anouar Smaoui from the English department at the Faculty of Science of Sfax for carefully proofreading and polishing the language of the present paper.

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Copyright information

© University of Navarra 2010

Authors and Affiliations

  • Khaled Hamden
    • 1
    • 2
    Email author
  • Bassem Jaouadi
    • 3
  • Nedia Zaraî
    • 3
  • Tarek Rebai
    • 4
  • Serge Carreau
    • 5
  • Abdelfattah Elfeki
    • 2
  1. 1.Biotechnology High School of Sfax (ISBS)SfaxTunisia
  2. 2.Laboratory of Animal Ecophysiology, Faculty of Science of SfaxSfaxTunisia
  3. 3.Laboratory of Microorganisms and Biomolecules, Centre of Biotechnology of SfaxSfaxTunisia
  4. 4.Laboratory of Histology–EmbryologyFaculty of Medicine of SfaxSfaxTunisia
  5. 5.Department of BiochemistryUniversity of Caen-Basse Normandie, USC INRACHU-CaenFrance

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