References
Feigin VL, Stark BA, Johnson CO, Roth GA, Bisignano C, Abady GG, Abbasifard M, Abbasi-Kangevari M, Abd-Allah F, Abedi V, Abualhasan A. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the global burden of disease study 2019. Lancet Neurol. 2021;(20):795–820.
Yang SH, et al. Precision medicine for ischemic stroke, let us move beyond time is brain. Transl Stroke Res. 2018;9:93–5.
Cohen JC, et al. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med. 2006;354:1264–72.
Sabatine MS, et al. Evolocumab and clinical outcomes in patients with cardiovascular disease. N Engl J Med. 2017;376:1713–22.
Hu H, et al. Mutational landscape of secondary glioblastoma guides met-targeted trial in brain tumor. Cell. 2018;175:1665–1678.e1618.
Farkhondeh A, et al. Induced pluripotent stem cells for neural drug discovery. Drug Discov Today. 2019;24:992–9.
Wang J, et al. Bioavailability of edaravone sublingual tablet versus intravenous infusion in healthy male volunteers. Clin Ther. 2018;40:1683–91.
Chen X, et al. Predicting the pharmacokinetic characteristics of edaravone intravenous injection and sublingual tablet through modeling and simulation. Clin Ther. 2020;42:428–38.
Absinta M, et al. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. eLife. 2017;6:e29738.
Wang Y, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369:11–9.
Wang Y, et al. Ticagrelor plus aspirin versus clopidogrel plus aspirin for platelet reactivity in patients with minor stroke or transient ischaemic attack: open label, blinded endpoint, randomised controlled phase II trial. BMJ. 2019;365:l2211.
Wang Y, et al. Ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA. N Engl J Med. 2021;385:2520–30.
Acknowledgements
We appreciate Tao Xin from the Department of Applied Linguistics, School of Medical Humanities, Capital Medical University, for the language editing assistance.
Funding
This study was supported by grants from the National Natural Science Foundation of China (No. 81825007, 81901177, 82101358), Beijing Outstanding Young Scientist Program (No. BJJWZYJH01201910025030), Youth Beijing Scholar Program (No.010), Beijing Talent Project-Class A: Innovation and Development (No. 2018A12), “National Ten-Thousand Talent Plan”-Leadership of Scientific and Technological Innovation, Beijing Hospitals Authority Youth Programme (QML20200501), and the Young Elite Scientist Sponsorship Program from China Association for Science and Technology (2019QNRC001).
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Chen, W., Wang, Y., Jiang, L. et al. New Drug Developments for Stroke: from Basics to Clinics. Transl. Stroke Res. 15, 335–338 (2024). https://doi.org/10.1007/s12975-023-01130-y
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DOI: https://doi.org/10.1007/s12975-023-01130-y