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Parkinson’s Disease and Ischemic Stroke: a Bidirectional Mendelian Randomization Study

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Abstract

We aimed to assess the potential causal association between Parkinson’s disease (PD) and ischemic stroke (IS) with Mendelian randomization methods. Summary statistics data from two large-scale genome-wide association studies (GWAS) for 33,674 PD cases and 40,585 IS cases were used in this study. We used inverse variance-weighted method for primary analysis, and four other Mendelian randomization methods (weighted median, MR-Egger regression methods, robust adjusted profile score, radial regression) to test whether PD was causal for IS and its subtypes. Analyses were bidirectional to assess reverse causality. Primary analysis showed PD had a significantly causal association with IS (OR 1.04; 95% CI, 1.02–1.07; p = 0.0019), and two subtypes of IS, cardioembolic stroke (OR 1.11; 95% CI, 1.06–1.18; p = 0.0001) and large artery stroke (OR 1.08; 95% CI, 1.01–1.15; p = 0.034), but not with small-vessel stroke (p = 0.180). The point estimates from sensitivity analyses were in the same direction. There was no strong evidence for a reverse causal association between PD and IS. Using multiple Mendelian randomization methods based on large-scale GWAS, PD is a potential cause of cardioembolic stroke and large artery stroke, but not small-vessel stroke. Ischemic stroke does not cause PD.

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Acknowledgements

The authors thank Prof. Yi Tang from the Department of Neurology, Xuanwu Hospital, Capital Medical University, for his professional opinions regarding the clinical linkage between Parkinson’s disease and ischemic stroke.

Funding

This study received funding from Xuanwu Hospital Hospital-Level Foundation (XWJL-2019001), Beijing Municipal Administration of Hospitals Incubating Program (PX2020034), and The Beijing Scientific and Technologic Project (Z201100005520019).

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Authors and Affiliations

  1. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China

    Shiyuan Fang, Tao Wang, Ran Xu, Xiao Zhang, Jichang Luo, Yan Ma & Liqun Jiao

  2. Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China

    Shiyuan Fang & Xinzhi Hu

  3. China International Neuroscience Institute (China-INI), Beijing, 100053, China

    Tao Wang, Yan Ma & Liqun Jiao

  4. National Heart & Lung Institute, Faculty of Medicine, Imperial College London, London, SW3 6LY, UK

    Yutong Yang

  5. Neuroendovascular Program, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA

    Aman B. Patel & Adam A. Dmytriw

  6. Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, 45 Changchunjie Street, Xicheng District, Beijing, 100053, China

    Adam A. Dmytriw & Liqun Jiao

Authors
  1. Shiyuan Fang
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  2. Xinzhi Hu
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  3. Tao Wang
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  4. Yutong Yang
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  5. Ran Xu
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  6. Xiao Zhang
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  7. Jichang Luo
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  8. Yan Ma
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  9. Aman B. Patel
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  10. Adam A. Dmytriw
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  11. Liqun Jiao
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Corresponding authors

Correspondence to Adam A. Dmytriw or Liqun Jiao.

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Shiyuan Fang, Xinzhi Hu and Tao Wang are co-first authors.

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Fang, S., Hu, X., Wang, T. et al. Parkinson’s Disease and Ischemic Stroke: a Bidirectional Mendelian Randomization Study. Transl. Stroke Res. 13, 528–532 (2022). https://doi.org/10.1007/s12975-021-00974-6

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  • DOI: https://doi.org/10.1007/s12975-021-00974-6

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