Skip to main content

Advertisement

SpringerLink
Log in

Old but Still Hot Target, Glutamate-Mediated Neurotoxicity in Stroke

  • Commentary
  • Published:
Translational Stroke Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Choi DW. Excitotoxicity: still hammering the ischemic brain in 2020. Front Neurosci. 2020;14:579953. https://doi.org/10.3389/fnins.2020.579953.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Zhang Q, Yang H, Gao H, Liu X, Li Q, Rong R, et al. PSD-93 interacts with SynGAP and promotes SynGAP ubiquitination and ischemic brain injury in mice. Transl Stroke Res. 2020;11(5):1137–47. https://doi.org/10.1007/s12975-020-00795-z.

    Article  CAS  PubMed  Google Scholar 

  3. Armstead WM, Hekierski H, Pastor P, Yarovoi S, Higazi AA, Cines DB. Release of IL-6 after stroke contributes to impaired cerebral autoregulation and hippocampal neuronal necrosis through NMDA receptor activation and upregulation of ET-1 and JNK. Transl Stroke Res. 2019;10(1):104–11. https://doi.org/10.1007/s12975-018-0617-z.

    Article  CAS  PubMed  Google Scholar 

  4. Wu KJ, Chen YH, Bae EK, Song Y, Min W, Yu SJ. Human milk oligosaccharide 2’-fucosyllactose reduces neurodegeneration in stroke brain. Transl Stroke Res. 2020;11(5):1001–11. https://doi.org/10.1007/s12975-019-00774-z.

    Article  CAS  PubMed  Google Scholar 

  5. Yin A, Guo H, Tao L, Cai G, Wang Y, Yao L, et al. NDRG2 protects the brain from excitotoxicity by facilitating interstitial glutamate uptake. Transl Stroke Res. 2020;11(2):214–27. https://doi.org/10.1007/s12975-019-00708-9.

    Article  CAS  PubMed  Google Scholar 

  6. Sun JY, Zhao SJ, Wang HB, Hou YJ, Mi QJ, Yang MF, et al. Ifenprodil improves long-term neurologic deficits through antagonizing glutamate-induced excitotoxicity after experimental subarachnoid hemorrhage. Transl Stroke Res. 2021. https://doi.org/10.1007/s12975-021-00906-4.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Kawakita F, Kanamaru H, Asada R, Imanaka-Yoshida K, Yoshida T, Suzuki H. Inhibition of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptor reduces acute blood-brain barrier disruption after subarachnoid hemorrhage in mice. Transl Stroke Res. 2021. https://doi.org/10.1007/s12975-021-00934-0.

    Article  PubMed  Google Scholar 

  8. Zhang C, Jiang M, Wang WQ, Zhao SJ, Yin YX, Mi QJ, et al. Selective mGluR1 negative allosteric modulator reduces blood-brain barrier permeability and cerebral edema after experimental subarachnoid hemorrhage. Transl Stroke Res. 2020;11(4):799–811. https://doi.org/10.1007/s12975-019-00758-z.

    Article  CAS  PubMed  Google Scholar 

  9. Suzuki H, Kanamaru H, Kawakita F, Asada R, Fujimoto M, Shiba M. Cerebrovascular pathophysiology of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Histol Histopathol. 2021;36(2):143–58. https://doi.org/10.14670/HH-18-253.

    Article  CAS  PubMed  Google Scholar 

  10. Chung DY, Oka F, Ayata C. Spreading depolarizations: a therapeutic target against delayed cerebral ischemia after subarachnoid hemorrhage. J Clin Neurophysiol. 2016;33(3):196–202. https://doi.org/10.1097/WNP.0000000000000275.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Funding

This study was funded by a grant-in-aid for Scientific Research from Japan Society for the Promotion of Science KAKENHI grant number JP20K09346 to Dr. Suzuki, JP20K17963 to Dr. Kawakita, JP21K16605 to Dr. Nakano, JP19K18423 to Dr. Nishikawa, and OKASAN-KATO FOUNDATION (grant number, N/A) to Dr. Fujimoto.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Hidenori Suzuki, Fumihiro Kawakita, Reona Asada, Fumi Nakano, Hirofumi Nishikawa & Masashi Fujimoto

Authors
  1. Hidenori Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fumihiro Kawakita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Reona Asada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fumi Nakano
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hirofumi Nishikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masashi Fujimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hidenori Suzuki.

Ethics declarations

Ethics Approval

This article does not contain any studies with human participants or animals performed by the authors.

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Suzuki, H., Kawakita, F., Asada, R. et al. Old but Still Hot Target, Glutamate-Mediated Neurotoxicity in Stroke. Transl. Stroke Res. 13, 216–217 (2022). https://doi.org/10.1007/s12975-021-00958-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12975-021-00958-6

Search

Navigation