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The Two Faces of Estrogen in Experimental Hemorrhagic Stroke

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References

  1. Carcel C, Woodward M, Wang X, Bushnell C, Sandset EC. Sex matters in stroke: a review of recent evidence on the differences between women and men. Front Neuroendocrinol. 2020;59:100870. https://doi.org/10.1016/j.yfrne.2020.100870.

    Article  PubMed  Google Scholar 

  2. de Rooij NK, Linn FH, van der Plas JA, Algra A, Rinkel GJ. Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends. J Neurol Neurosurg Psychiatry. 2007;78(12):1365–72. https://doi.org/10.1136/jnnp.2007.117655.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Bushnell CD, Chaturvedi S, Gage KR, Herson PS, Hurn PD, Jimenez MC, et al. Sex differences in stroke: challenges and opportunities. J Cereb Blood Flow Metab. 2018;38(12):2179–91. https://doi.org/10.1177/0271678X18793324.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Oka M, Ono I, Shimizu K, Kushamae M, Miyata H, Kawamata T, et al. The bilateral ovariectomy in a female animal exacerbates the pathogenesis of an intracranial aneurysm. Brain Sci. 2020;10(6):335. https://doi.org/10.3390/brainsci10060335.

    Article  CAS  PubMed Central  Google Scholar 

  5. Nakamura T, Xi G, Hua Y, Schallert T, Hoff JT, Keep RF. Intracerebral hemorrhage in mice: model characterization and application for genetically modified mice. J Cereb Blood Flow Metab. 2004;24(5):487–94. https://doi.org/10.1097/00004647-200405000-00002.

    Article  PubMed  Google Scholar 

  6. Xie Y, Li YJ, Lei B, Kernagis D, Liu WW, Bennett ER, et al. Sex differences in gene and protein expression after intracerebral hemorrhage in mice. Transl Stroke Res. 2019;10(2):231–9. https://doi.org/10.1007/s12975-018-0633-z.

    Article  CAS  PubMed  Google Scholar 

  7. Peng K, Koduri S, Xia F, Gao F, Hua Y, Keep RF, et al. Impact of sex differences on thrombin-induced hydrocephalus and white matter injury: the role of neutrophils. Fluids Barriers CNS. 2021;18(1):38. https://doi.org/10.1186/s12987-021-00273-0.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Yanagisawa T, Zhang H, Suzuki T, Kamio Y, Takizawa T, Morais A, et al. Sex and genetic background effects on the outcome of experimental intracranial aneurysms. Stroke. 2020;51(10):3083–94. https://doi.org/10.1161/STROKEAHA.120.029651.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Shishido H, Zhang H, Okubo S, Hua Y, Keep RF, Xi G. The effect of gender on acute hydrocephalus after experimental subarachnoid hemorrhage. Acta Neurochir Suppl. 2016;121:335–9. https://doi.org/10.1007/978-3-319-18497-5_58.

    Article  PubMed  Google Scholar 

  10. Zhang J, Peng K, Ye F, Koduri S, Hua Y, Keep RF, et al. Acute T2*-weighted magnetic resonance imaging detectable cerebral thrombosis in a rat model of subarachnoid hemorrhage. Transl Stroke Res. 2021. https://doi.org/10.1007/s12975-021-00918-0.

    Article  PubMed  PubMed Central  Google Scholar 

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Funding

NC, YH, RFK, SK, ASP, and GX were supported by grants NS-007222, NS104663, NS106746, NS108042, NS112394, and NS116786 from the National Institutes of Health (NIH).

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Correspondence to Sravanthi Koduri or Guohua Xi.

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All institutional and national guidelines for the care and use of laboratory animals were followed.

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Sravanthi Koduri, Richard F. Keep, Ya Hua, Neeraj Chaudhary, Aditya S. Pandey, and Guohua Xi declare that they have no conflict of interest. Guohua Xi is Associate Editor of the Translational Stroke Research.

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Koduri, S., Keep, R.F., Hua, Y. et al. The Two Faces of Estrogen in Experimental Hemorrhagic Stroke. Transl. Stroke Res. 13, 362–363 (2022). https://doi.org/10.1007/s12975-021-00942-0

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  • DOI: https://doi.org/10.1007/s12975-021-00942-0

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