Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy

Abstract

Stroke is a debilitating condition which is also the second leading cause of death and disability worldwide. Despite the benefits and promises shown by numerous neuroprotective agents in animal stroke models, their clinical translation has not been a complete success. Hence, search for treatment options have directed researchers towards utilising stem cells. Mitochondria has a major involvement in the pathophysiology of stroke and a number of other conditions. Stem cells have shown the ability to transfer mitochondria to the damaged cells and to help revive cell energetics in the recipient cell. The present review discusses how stem cells could be employed to protect neurons and mitochondria in stroke and also the various mechanisms involved in neuroprotection.

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Funding

The authors acknowledge the Department of Science and Technology (DST), Govt. of India, for their financial support through grant (SB/YS/LS-196/2014), International Society for Neurochemistry (ISN) Return Home grant, Department of Pharmaceuticals, Ministry of Chemical and Fertilisers, Govt of India and National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, India. The authors also want to express their thanks to the Director, NIPER Ahmedabad, for providing necessary support.

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Correspondence to Pallab Bhattacharya.

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Sarmah, D., Kaur, H., Saraf, J. et al. Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy. Transl. Stroke Res. 10, 121–136 (2019). https://doi.org/10.1007/s12975-018-0642-y

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Keywords

  • Stroke
  • Mitochondria
  • Reactive oxygen species
  • Neuroprotection
  • Tunnelling nanotubes
  • Extracellular vesicles
  • Cell fusion