Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy

  • Deepaneeta Sarmah
  • Harpreet Kaur
  • Jackson Saraf
  • Kanchan Vats
  • Kanta Pravalika
  • Madhuri Wanve
  • Kiran Kalia
  • Anupom Borah
  • Akhilesh Kumar
  • Xin Wang
  • Dileep R. Yavagal
  • Kunjan R. Dave
  • Pallab BhattacharyaEmail author
Review Article


Stroke is a debilitating condition which is also the second leading cause of death and disability worldwide. Despite the benefits and promises shown by numerous neuroprotective agents in animal stroke models, their clinical translation has not been a complete success. Hence, search for treatment options have directed researchers towards utilising stem cells. Mitochondria has a major involvement in the pathophysiology of stroke and a number of other conditions. Stem cells have shown the ability to transfer mitochondria to the damaged cells and to help revive cell energetics in the recipient cell. The present review discusses how stem cells could be employed to protect neurons and mitochondria in stroke and also the various mechanisms involved in neuroprotection.


Stroke Mitochondria Reactive oxygen species Neuroprotection Tunnelling nanotubes Extracellular vesicles Cell fusion 



The authors acknowledge the Department of Science and Technology (DST), Govt. of India, for their financial support through grant (SB/YS/LS-196/2014), International Society for Neurochemistry (ISN) Return Home grant, Department of Pharmaceuticals, Ministry of Chemical and Fertilisers, Govt of India and National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, India. The authors also want to express their thanks to the Director, NIPER Ahmedabad, for providing necessary support.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Ethical Approval

This article does not contain any studies with animals performed by any of the authors.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Deepaneeta Sarmah
    • 1
  • Harpreet Kaur
    • 1
  • Jackson Saraf
    • 1
  • Kanchan Vats
    • 1
  • Kanta Pravalika
    • 1
  • Madhuri Wanve
    • 1
  • Kiran Kalia
    • 1
  • Anupom Borah
    • 2
  • Akhilesh Kumar
    • 3
  • Xin Wang
    • 4
  • Dileep R. Yavagal
    • 5
  • Kunjan R. Dave
    • 5
  • Pallab Bhattacharya
    • 1
    Email author
  1. 1.Department or Pharmacology and ToxicologyNational Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A)GandhinagarIndia
  2. 2.Cellular and Molecular Neurobiology Laboratory, Department of Life Science and BioinformaticsAssam UniversitySilcharIndia
  3. 3.Department of BotanyBanaras Hindu UniversityVaranasiIndia
  4. 4.Department of Neurosurgery, Harvard Medical SchoolBrigham and Women’s HospitalBostonUSA
  5. 5.Department of NeurologyUniversity of Miami Miller School of MedicineFloridaUSA

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