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Do the Risk Factors Determine the Severity and Outcome of Cerebral Venous Sinus Thrombosis?

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Abstract

We report the burden of risk factors in cerebral venous sinus thrombosis (CVST) and its relationship with the clinical severity, extent of MRI and MRV abnormality, and outcome. One hundred and twenty-eight consecutive patients with CVST were included. Their demographic, presenting symptoms and neurological findings were noted and risk factors of CVST were evaluated. The outcomes were assessed using modified Rankin Scale (mRS). Based on the risk factors, the patients could be categorized as prothrombotic conditions only in 46 (35.9%), prothrombotic with other risk factors in 36 (28.1%), non-prothrombotic risk factors in 20 (15.6%), and no risk factors in 26 (20.3%). More than two risk factors were present in 33 (25.8%). Sixteen out of 22 (72.7%) patients with female gender-specific risk factors also had other prothrombotic conditions. On MRV, more than two sinuses were involved in 35 (27.3%) patients and 94 (73.4%) patients had parenchymal lesions on MRI. Thirty-one (24.2%) patients had poor outcome (mRS > 2) at discharge and 25/122 (20.5%) at 3 months. The number of risk factors was not related to clinical severity and extent of MRI or MRV abnormality. On multivariate analysis, age (OR 1.05, 95%CI 1.00–1.09, P = 0.03), GCS score (OR 5.30, 95%CI 1.25–22.24, P = 0.02), and mechanical ventilation (OR 196.17, 95%CI 16.05, P = 0.001) predicted the outcome at 3 months.

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Acknowledgements

We thank Mr. Shakti Kumar for the secretarial help.

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Correspondence to Usha K. Misra.

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The authors declare that they have no conflict of interest.

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Research Involving Human Participants and/or Animals

Observational study, involves routine management.

Ethical Approval

This study was approved by the Institutional Ethics Committee (PGI/BE/774).

Additional information

Highlights:

• Prothrombotic state is the commonest cause of CVST (64%).

• Twenty percent patients may not have risk factor.

• Multiple risk factors were more frequent than single risk factor for occurrence of CVST.

• Burden of risk factors does not determine clinico-radiological severity and outcome.

• Need for mechanical ventilation, GCS score and elderly patients were independent predictors for poor clinical outcome.

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Kalita, J., Misra, U.K. & Singh, R.K. Do the Risk Factors Determine the Severity and Outcome of Cerebral Venous Sinus Thrombosis?. Transl. Stroke Res. 9, 575–581 (2018). https://doi.org/10.1007/s12975-017-0607-6

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