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Cofilin as a Promising Therapeutic Target for Ischemic and Hemorrhagic Stroke

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Abstract

Neurovascular unit (NVU) is considered as a conceptual framework for investigating the mechanisms as well as developing therapeutic targets for ischemic and hemorrhagic stroke. From a molecular perspective, oxidative stress, excitotoxicity, inflammation, and disruption of the blood brain barrier are broad pathophysiological frameworks on the basis on which potential therapeutic candidates for ischemic and hemorrhagic stroke could be discussed. Cofilin is a potent actin-binding protein that severs and depolymerizes actin filaments in order to generate the dynamics of the actin cytoskeleton. Although studies of the molecular mechanisms of cofilin-induced reorganization of the actin cytoskeleton have been ongoing for decades, the multicellular functions of cofilin and its regulation in different molecular pathways are expanding beyond its primary role in actin cytoskeleton. This review focuses on the role of cofilin in oxidative stress, excitotoxicity, inflammation, and disruption of the blood brain barrier in the context of NVU as well as how and why cofilin could be studied further as a potential target for ischemic and hemorrhagic stroke.

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    Authors and Affiliations

    1. Department of Medicinal and Biological Chemistry, University of Toledo, Toledo, OH, 43614, USA

      Qasim Alhadidi & Zahoor A. Shah

    2. Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH, 43614, USA

      Muhammad Shahdaat Bin Sayeed & Zahoor A. Shah

    3. Department of Medicinal and Biological Chemistry, Department of Pharmacology and Experimental Therapeutics, University of Toledo, 3000 Arlington Avenue, Toledo, OH, 43614, USA

      Zahoor A. Shah

    Authors
    1. Qasim Alhadidi
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    2. Muhammad Shahdaat Bin Sayeed
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    3. Zahoor A. Shah
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    Corresponding author

    Correspondence to Zahoor A. Shah.

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    Funding

    Qasim Alhadidi is supported by the Higher Committee for Education Development in Iraq and Muhammad Shahdaat Bin Sayeed is supported by the Fulbright Program sponsored by the U.S. Department of State’s Bureau of Educational and Cultural Affairs.

    Conflict of Interest

    The authors declare that they have no competing interests.

    Ethical Approval

    No animals were used in this study.

    Additional information

    Qasim Alhadidi and Muhammad Shahdaat Bin Sayeed contributed equally to this work.

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    Cite this article

    Alhadidi, Q., Bin Sayeed, M.S. & Shah, Z.A. Cofilin as a Promising Therapeutic Target for Ischemic and Hemorrhagic Stroke. Transl. Stroke Res. 7, 33–41 (2016). https://doi.org/10.1007/s12975-015-0438-2

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    • DOI: https://doi.org/10.1007/s12975-015-0438-2

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