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The Single and Double Blood Injection Rabbit Subarachnoid Hemorrhage Model

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Abstract

Over the past 30 years, the rabbit subarachnoid hemorrhage model (SAH) has been used for investigating the post-hemorrhage pathology, especially with respect to understanding of the mechanisms of cerebral vasospasm. However, the molecular mechanisms of cerebral vasospasm remain to be elucidated. Furthermore, it is not clear whether the rabbit SAH model is suitable for the investigation of pathological conditions other than cerebral vasospasm, such as early brain injury. Therefore, the properties of the rabbit SAH model need to be validated, and the reasons for using the rabbit should be clarified. This review explores the settings and technical issues of establishing a rabbit cisterna magna single and double blood injection SAH model and discusses the characteristics and feasibilities of the models.

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Acknowledgments

This research was supported by JSPS KAKENHI (Grant Numbers 24791510, 25670624, and 26462164).

Compliance with Ethics Requirements

All institutional and national guidelines for the care of laboratory animals were followed.

Conflict of Interest

Yuichiro Kikkawa, Ryota Kurogi, and Tomio Sasaki declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Yuichiro Kikkawa, Ryota Kurogi & Tomio Sasaki

  2. Department of Cerebrovascular surgery, International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka-city, Saitama, 350-1298, Japan

    Yuichiro Kikkawa

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  1. Yuichiro Kikkawa
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  2. Ryota Kurogi
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Correspondence to Yuichiro Kikkawa.

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Kikkawa, Y., Kurogi, R. & Sasaki, T. The Single and Double Blood Injection Rabbit Subarachnoid Hemorrhage Model. Transl. Stroke Res. 6, 88–97 (2015). https://doi.org/10.1007/s12975-014-0375-5

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