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Aneurysm Shape Reconstruction from Biplane Angiograms in the ISUIA Collection

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Abstract

The International Study of Unruptured Intracranial Aneurysms (ISUIA) is an epidemiologic international study of the natural history of unruptured intracranial aneurysms that enrolled 4,060 subjects. A conventional biplane cerebral angiogram available for central review was required for enrollment resulting in a large database. Data on aneurysms that ruptured during follow-up of the 1,692 untreated subjects provides an opportunity to investigate the anatomic features that may be predictive of future rupture. The objective of the study is to develop and test a method for three-dimensional (3D) shape reconstruction of aneurysms using biplane angiographic data in the ISUIA for retrospective morphometric assessment. Beginning with the two boundaries of the biplane views, curve morphing techniques were employed to estimate a number of intermediate boundaries around the aneurysm sac resulting in the creation of a 3D sac surface. The method was tested using simulated biplane “angiograms” of pre-reconstructed 3D models of patient-specific aneurysms. An algorithm to perform the image analysis was developed, and the morphometric indices of 150 intracranial aneurysms in the ISUIA database were estimated. Simultaneously, experienced neuroradiologists made manual measurements of key dimensions in the sac from the biplane angiograms for all cases. 3D reconstructions using our proposed method matched well with the original pre-reconstructed 3D geometries and were consistent with manual measurements of the neuroradiologists for the ISUIA aneurysms. A method for reconstructing the 3D geometry of the intracranial aneurysm sac from biplane angiograms in the ISUIA database with reasonable fidelity has been developed.

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Acknowledgments

This study was funded by NIH grant #5RC1 NS068092-02. It was supported in part by funding from NIH grant #5 R01 HL083475.

Compliance with Ethics Requirements

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Conflict of Interest

Madhavan Raghavan declares that he has no conflict of interest.

Gaurav V. Sharda declares that he has no conflict of interest.

John Huston III declares that he has no conflict of interest.

J Mocco is a consultant to Lazaus Effect, Pulsar, Reverse Medical and Edge Therapeutics; he is an investor in Blockade Medical and Medina Medical.

Ana W. Capuano declares that she has no conflict of interest.

James C. Torner declares that he has no conflict of interest.

Punam K. Saha declares that he has no conflict of interest.

Irene Meissner declares that she has no conflict of interest.

Robert D. Brown Jr. declares that he has no conflict of interest.

Human Subjects Research

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA

    Madhavan L. Raghavan & Gaurav V. Sharda

  2. Department of Radiology, Mayo Clinic, Rochester, MN, USA

    John Huston III

  3. Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA

    J Mocco

  4. Department of Epidemiology, University of Iowa, Iowa City, IA, USA

    Ana W. Capuano & James C. Torner

  5. Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA

    Punam K. Saha

  6. Department of Neurology, Mayo Clinic, Rochester, MN, USA

    Irene Meissner & Robert D. Brown Jr.

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  1. Madhavan L. Raghavan
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  2. Gaurav V. Sharda
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  3. John Huston III
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  4. J Mocco
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  5. Ana W. Capuano
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  7. Punam K. Saha
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  8. Irene Meissner
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  9. Robert D. Brown Jr.
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for the International Study of Unruptured Intracranial Aneurysms Investigators

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Correspondence to Madhavan L. Raghavan.

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Raghavan, M.L., Sharda, G.V., Huston, J. et al. Aneurysm Shape Reconstruction from Biplane Angiograms in the ISUIA Collection. Transl. Stroke Res. 5, 252–259 (2014). https://doi.org/10.1007/s12975-014-0330-5

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  • DOI: https://doi.org/10.1007/s12975-014-0330-5

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