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Multimodal MRI of Nonhuman Primate Stroke

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Abstract

Stroke is the fourth leading cause of death. Despite decades of research, no neuroprotective drug has proven to be effective clinically. One widely accepted view to account for this negative outcome is that the rodent stroke model simply does not adequately reflect the complexity of human stroke. Recent failures of several high-profile neuroprotective drugs for stroke treatment in phase III clinical trials further underscore the importance of developing adequate animal models for stroke research. The brain organization and vascular circuitry of nonhuman primates (NHPs) are more homologous with humans than the widely used rodent for stroke modeling. The Stroke Therapy Academic Industry Roundtable, a national committee commissioned by the American Heart Association, recommended that clinically relevant NHP stroke models be established for developing and assessing neuroprotective drugs. The aim of this article is to review the challenges and applications of magnetic resonance imaging studies of NHP stroke models.

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Acknowledgments

This work was supported by the American Heart Association Established Investigator Award 0940104N, National Institute of Health (NINDS R01 NS45879) and Clinical Translational Science Award’s imaging supplement (parent grant UL1RR025767) to TQD. HYW was supported by a predoctoral fellowship (11PRE5670005) from the American Heart Association and by a Translational Science Training Grant from the Institute for Integration of Medicine and Science, University of Texas Health Science Center.

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Authors and Affiliations

  1. Athinoula. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachussetts General Hospital, Harvard Medical School, Building 120, 2nd Ave., Charlestown, Boston, MA, USA

    Hsiao-Ying Wey

  2. Research Imaging Institute, University of Texas Health Science Center, 8403 Floyd Curl Drive, San Antonio, TX, 78229, USA

    Hsiao-Ying Wey & Timothy Q. Duong

  3. Department of Radiology, University of Texas Health Science Center, San Antonio, TX, USA

    Hsiao-Ying Wey & Timothy Q. Duong

  4. Department of Ophthalmology, University of Texas Health Science Center, San Antonio, TX, USA

    Timothy Q. Duong

  5. Department of Physiology, University of Texas Health Science Center, San Antonio, TX, USA

    Timothy Q. Duong

  6. South Texas Veterans Health Care System, San Antonio, TX, USA

    Timothy Q. Duong

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  1. Hsiao-Ying Wey
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Correspondence to Timothy Q. Duong.

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Wey, HY., Duong, T.Q. Multimodal MRI of Nonhuman Primate Stroke. Transl. Stroke Res. 3, 84–89 (2012). https://doi.org/10.1007/s12975-012-0145-1

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