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Therapeutic Targeting of Astrocytes After Traumatic Brain Injury

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Abstract

Traumatic brain injury (TBI) remains a leading cause of mortality and morbidity worldwide. A major focus of preclinical research has focused on understanding the mechanisms of acute cell death after TBI; however, translation of these findings into the clinic has failed to improve long-term patient outcomes. Recent work suggests astrocytes, the predominant cell type within the human brain, may actively contribute to neurological demise by exacerbating secondary brain injury after TBI. Along these lines, astrocytes may promote neuroinflammation, increase the development of cerebral edema, and contribute to elevated intracranial pressure after brain injury. The primary goal of this mini-review is to summarize the growing body of literature that suggests reactive astrocytes influence the brain response to TBI. To maintain focus, we will limit our discussion to the mechanisms of cerebral edema.

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Acknowledgments

The authors’ work is supported in part by grants from the National Institute of Health (NS065172) and American Heart Association (BGIA2300135).

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  1. Department of Neurosurgery, Georgia Health Sciences University, 1120 15th Street, Augusta, GA, 30912, USA

    Jessica Shields, Donald E. Kimbler, Walid Radwan, Sangeetha Sukumari-Ramesh & Krishnan M. Dhandapani

  2. Department of Radiology, Georgia Health Sciences University, Augusta, GA, 30912, USA

    Nathan Yanasak

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  1. Jessica Shields
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Correspondence to Krishnan M. Dhandapani.

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Shields, J., Kimbler, D.E., Radwan, W. et al. Therapeutic Targeting of Astrocytes After Traumatic Brain Injury. Transl. Stroke Res. 2, 633–642 (2011). https://doi.org/10.1007/s12975-011-0129-6

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