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MRI Stem Cell Tracking for Therapy in Experimental Cerebral Ischemia

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Abstract

Magnetic resonance has an established role in investigations on the evolution of stroke and the assessment of therapeutic strategies in experimental animals. Here we show that the technique has also an important place for the study of stem cell-mediated regenerative therapies after stroke. We review the literature by bridging from the methodological aspects of stem cell labeling via grafting and monitoring of cell dynamics after implantation into the brain all the way to MRI's role in analyzing the stem cell-mediated functional improvement. Thus, we have aimed at a view combining the focus on the monitoring of the cell activities with the aspect of lesion evolution while including also the essence of a potential functional improvement by the implantation of stem cells following stroke.

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Acknowledgment

Financial support from the EU grant HEALTH-F5-2008-201842 (ENCITE) and from the funds by the German Federal Ministry of Education and Research (BMBF-0314104) are gratefully acknowledged. P R-C acknowledges the Instituto Carlos III of the Spanish Ministry of Health for a research contract of the Miguel Servet program.

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Authors and Affiliations

  1. Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, IDIS, Santiago de Compostela, Spain

    Pedro Ramos-Cabrer

  2. In-Vivo-NMR Laboratory, Max Planck Institute for Neurological Research, Gleuelerstrasse 50, 50931, Cologne, Germany

    Mathias Hoehn

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  1. Pedro Ramos-Cabrer
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  2. Mathias Hoehn
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Correspondence to Mathias Hoehn.

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Ramos-Cabrer, P., Hoehn, M. MRI Stem Cell Tracking for Therapy in Experimental Cerebral Ischemia. Transl. Stroke Res. 3, 22–35 (2012). https://doi.org/10.1007/s12975-011-0111-3

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  • DOI: https://doi.org/10.1007/s12975-011-0111-3

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