Skip to main content

Advertisement

SpringerLink
Log in

The association of PRECISE-DAPT score with development of contrast-induced nephropathy in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

  • Original Article
  • Published:
Cardiovascular Intervention and Therapeutics Aims and scope Submit manuscript

Abstract

Given that parameters used in the calculation of the PRECISE-DAPT risk score are important contributors to contrast-induced nephropathy (CIN) development, we hypothesized that the PRECISE-DAPT risk score would show good accuracy for predicting CIN in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Therefore, in this study, we aimed to determine the predictive value of the admission PRECISE-DAPT score for the occurrence of CIN in patients with STEMI treated with primary PCI. After evaluation regarding with exclusion criteria, 1280 patients were, respectively, enrolled in the study. The primary end-point was the incidence of CIN. The PRECISE-DAPT score of CIN group was higher than the non-CIN group [31 (24–41) vs. 14 (9–23), p < 0.001, respectively]. In multivariate logistic regression analysis, PRECISE-DAPT score was independently associated with the development of CIN [odds ratio (OR) 1.090, 95% confidence interval (CI) 1.066–1.114, p < 0.001]. A receiver-operating characteristic (ROC) analysis was drawn to show the best cut-off value of the PRECISE-DAPT score to predict CIN was ≥ 21 with 81.3% sensitivity and 72.7% specificity [area under curve (AUC): 0.834; 95% CI 0.812–0.854; p = 0.017]. The PRECISE-DAPT score may be a significant independent predictor of CIN in patients with STEMI treated with primary PCI. Therefore, follow-up of patients with higher PRECISE-DAPT score should be performed more cautiously, and it should be noted that the development of CIN risk of these patients group is high.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Steg PG, James SK, Atar D, Badano LP, Blömstrom-Lundqvist C, Borger MA, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC). Eur Heart J. 2012;33:2569–619.

    Article  CAS  Google Scholar 

  2. Marenzi G, Lauri G, Assanelli E, Campodonico J, De Metrio M, Marana I, et al. Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction. J Am Coll Cardiol. 2004;44:1780–5.

    Article  PubMed  Google Scholar 

  3. Mehran R, Nikolsky E. Contrast-induced nephropathy: definition, epidemiology, and patients at risk. Kidney Int Suppl. 2006;100:11–5.

    Article  CAS  Google Scholar 

  4. Pucelikova T, Dangas G, Mehran R. Contrast-induced nephropathy. Catheter Cardiovasc Interv. 2008;71:62–72.

    Article  PubMed  Google Scholar 

  5. Yuan Y, Qiu H, Hu X, Luo T, Gao X, Zhao X, et al. Predictive value of inflammatory factors on contrast-induced acute kidney injury in patients who underwent an emergency percutaneous coronary intervention. Clin Cardiol. 2017;40:719–25.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Shacham Y, Gal-Oz A, Leshem-Rubinow E, Arbel Y, Flint N, Keren G, et al. Association of admission hemoglobin levels and acute kidney injury among myocardial infarction patients treated with primary percutaneous intervention. Can J Cardiol. 2015;31:50–5.

    Article  PubMed  Google Scholar 

  7. Kwasa EA, Vinayak S, Armstrong R. The role of inflammation in contrast-induced nephropathy. Br J Radiol. 2014;87:20130738.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Costa F, van Klaveren D, James S, Heg D, Räber L, Feres F, et al. Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual patient data sets from clinical trials. Lancet. 2017;389:1025–34.

    Article  PubMed  Google Scholar 

  9. Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, et al. Chronic kidney disease epidemiology collaboration. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145:247–54.

    Article  CAS  PubMed  Google Scholar 

  10. Thygesen K, Alpert JS, White HD. ESC, Committee for Practice Guidelines (CPG). Third universal definition of myocardial infarction. Eur Heart J. 2012;33:2551–67.

    Article  Google Scholar 

  11. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, et al. ESH/ESC guidelines for the management of arterial hypertension: the task force for the management of Arterial hypertension of the European society of hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2013;34:2159–219.

    Article  PubMed  Google Scholar 

  12. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25:1105–87.

    Article  CAS  PubMed  Google Scholar 

  13. Koskinas KC. Effect of Statins and non-statin LDL-lowering medications on cardiovascular outcomes in secondary prevention: a meta-analysis of randomized trials. Eur Heart J. 2018;39:1172–80.

    Article  CAS  PubMed  Google Scholar 

  14. Nutritional anemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser. 1968;405:5–37.

    Google Scholar 

  15. Andrassy KM. Comments on KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2013;84:622–3.

    Article  CAS  PubMed  Google Scholar 

  16. McCullough PA. Contrast-induced acute kidney injury. J Am Coll Cardiol. 2008;51:1419–28.

    Article  PubMed  Google Scholar 

  17. Raposeiras-Roubín S, Aguiar-Souto P, Barreiro-Pardal C, López Otero D, Elices Teja J, OcaranzaSanchez R, et al. GRACE risk score predicts contrast-induced nephropathy in patients with acute coronary syndrome and normal renal function. Angiology. 2013;64:31–9.

    Article  PubMed  Google Scholar 

  18. Bouzas-Mosquera A, Vázquez-Rodríguez JM, Calvino-Santos R, Peteiro-Vázquez J, Flores-Ríos X, Marzoa-Rivas R, et al. Contrast-induced nephropathy and acute renal failure following urgent cardiac catheterization: incidence, risk factors, and prognosis. Rev Esp Cardiol. 2007;60:1026–34.

    Article  PubMed  Google Scholar 

  19. Mehran R, Aymong ED, Nikolsky E, Lasic Z, Iakovou I, Fahy M, et al. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol. 2004;44:1393–9.

    PubMed  Google Scholar 

  20. Narula A, Mehran R, Weisz G, Dangas GD, Yu J, Généreux P, et al. Contrast-induced acute kidney injury after primary percutaneous coronary intervention: results from the HORIZONS-AMI substudy. Eur Heart J. 2014;35:1533–40.

    Article  CAS  PubMed  Google Scholar 

  21. Nozue T, Michishita I, Iwaki T, Mizuguchi I, Miura M. Contrast medium volume to estimated glomerular filtration rate ratio as a predictor of contrast-induced nephropathy developing after elective percutaneous coronary intervention. J Cardiol. 2009;54:214–20.

    Article  PubMed  Google Scholar 

  22. Anzai A, Anzai T, Naito K, Kaneko H, Mano Y, Jo Y, et al. Prognostic significance of acute kidney injury after reperfused ST-elevation myocardial infarction: synergistic acceleration of renal dysfunction and left ventricular remodelling. J Card Fail. 2010;16:381–99.

    Article  PubMed  Google Scholar 

  23. Stolker JM, McCullough PA, Rao S, Inzucchi SE, Spertus JA, Maddox TM, et al. Pre-procedural glucose levels and the risk for contrast-induced acute kidney injury in patients undergoing coronary angiography. J Am Coll Cardiol. 2010;55:1433–40.

    Article  CAS  PubMed  Google Scholar 

  24. Cicek G, Yıldırım E. CHA2DS2-VASc score predicts contrast induced nephropathy in patients with ST-segment elevation myocardial infarction who were undergoing primary percutaneous coronary intervention. Kardiol Pol. 2018;76:91–8.

    Article  PubMed  Google Scholar 

  25. Valgimigli M, BuenoH Byrne RA, Collet JP, Collet JP, Costa F, Jeppsson A, et al. ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: the task force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European association for cardio-thoracic surgery (EACTS). Eur Heart J. 2017;2018(39):213–60.

    Google Scholar 

  26. Chong E, Poh KK, Lu Q, Zhang JJ, Tan N, Hou XM, Ong HY, Azan A, Chen SL, Chen JY, Ali RM, Fang WY, Lau TW, Tan HC. Comparison of combination therapy of high-dose oral N-acetylcysteine and intravenous sodium bicarbonate hydration with individual therapies in the reduction of Contrast-induced Nephropathy during Cardiac Catheterization and Percutaneous Coronary Intervention (CONTRAST): a multi-center, randomized, controlled trial. Int J Cardiol. 2015;201:237–42.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sultan Abdülhamid Han Training and Research Hospital, Health Sciences University, Tibbiye Street, Uskudar, Istanbul, Turkey

    Tufan Çınar & Muhammed Keskin

  2. Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

    Veysel Ozan Tanık

  3. Sivas Numune Hospital, Sivas, Turkey

    Emre Aruğaslan

  4. Department of Cardiology, Kafkas University, Kafkas, Turkey

    Yavuz Karabağ, Metin Çağdaş & İbrahim Rencüzoğulları

Authors
  1. Tufan Çınar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Veysel Ozan Tanık
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Emre Aruğaslan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yavuz Karabağ
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Metin Çağdaş
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. İbrahim Rencüzoğulları
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Muhammed Keskin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tufan Çınar.

Ethics declarations

Conflict of interest

All authors declare that they do not have any conflict of interest.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

The need for written informed consent was waived due to retrospective study design.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Çınar, T., Tanık, V.O., Aruğaslan, E. et al. The association of PRECISE-DAPT score with development of contrast-induced nephropathy in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Cardiovasc Interv and Ther 34, 207–215 (2019). https://doi.org/10.1007/s12928-018-0545-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12928-018-0545-6

Keywords

Search

Navigation