Abstract
This article was prepared by a working group of paediatricians and gynaecologists belonging to the Association of Medicine and the Person as a proposal to be discussed at the Bioethical Commission of the National Federation of Italian Chambers of Physicians which took place in Ferrara on 24–25 October 2008. The document addressed four key aspects of the bioethics of the beginning of life: (1) a responsible sexuality under the aspect of prevention and contraception with particular attention to the crucial aspects of adolescence and emergency contraception; (2) medically assisted procreation starting from scientific studies and the evaluation of risks/benefits for individuals born from this practice, with special attention to genetic diagnosis prior to implant, in view of the substantial negative effects on the embryo and on the introduction of eugenic selection; (3) a responsible procreation, the protection of maternity and the voluntary interruption of pregnancy: what significance does each of these elements carry? What is the role of doctors in all this? What are the proposals to protect motherhood nowadays? What is the role of the doctors in pre-natal diagnosis and what information is provided to parents on the actual usefulness of these tests? (4) the decision not to resuscitate extremely premature babies, which has been discussed by the Italian Scientific Society of Neonatology, by the Italian National Commission of Bioethics and by the Italian High Council of Health Services. Some positions still emerge in regards to assistance of prematures which are at variance with the position of the three above mentioned organisations and of a great part of the scientific world.
Riassunto
Questo documento è stato preparato da un gruppo di lavoro composto da pediatri e ginecologi appartenenti all’Associazione Medicina e Persona come proposta per la Commissione di Bioetica della Federazione Nazionale degli Ordini dei Medici, riunitasi a Ferra ra il 24–25 ottobre scorso. Il documento tratta quattro punti relativi alla bioetica di inizio vita: (1) la sessualità responsabile sotto il profilo della prevenzione e della contraccezione con particolare riguardo a due aspetti cruciali riguardanti l’età adolescenziale e la contraccezione d’emergenza; (2) la procreazione medicalmente assistita affrontata a partire dalla valutazione della letteratura scientifica e quindi della valutazione rischi/benefici sulla popolazione nata da tale pratica di fecondazione; un cenno particolare alla diagnosi genetica pre-impianto in riferimento agli effetti negativi, non trascurabili, sull’embrione e sull’introduzione con essa della pratica della selezione eugenetica; (3) la procreazione cosciente e responsabile, la tutela della maternità e l’interruzione volontaria di gravidanza: che significato ha oggi ciascuno di questi termini? Che ruolo ha il medico in tutto questo? Quali sono le proposte per tutelare oggi la maternità? Che ruolo ha il medico nella diagnosi prenatale e quale informazione a riguardo è data ai genitori circa la reale utilità dell’indagine? Senza un’educazione l’esito è il consumismo prenatale; (4) la rianimazione del neonato estremamente pretermine. Quest’ultimo tema è stato recentemente affrontato dalla Società Scientifica di Neonatologia, dal Comitato Nazionale di Bioetica e dal Consiglio Superiore di Sanità. Continuano a permanere posizioni selettive riguardo all’assistenza neonatale non condivise dai tre organismi citati e da gran parte della letteratura scientifica che viene qui considerate.
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References
Raymond EG, Trussell J, Polis CB (2007) Population effect of increased access to emergency contraceptive pills: a systematic review. Obstet Gynecol 109:181–188
Glasier A, Fairhurst K, Wyke S et al (2004) Advanced provision of emergency contraception does not reduce abortion rates. Contraception 69:361–366
Glasier A (2006) Emergency contraception. Is it worth all the fuss? BMJ 333:560–561
Raymond EG, Weaver MA (2008) Effect of an emergency contraceptive pill intervention on pregnancy risk behavior. Contraception 77:333–336
Rascon JJ, Sandoica EA (2008) Ethics and efficacy in sexual health campaigns. Cuad Bioet 19:81–93
Stanford JB (2008) Emergency contraception: overestimated effectiveness and questionable expectations. Clin Pharmacol Ther 83:19–21
Tydén T, Aneblom G, von Essen L et al (2002) ]No reduced number of abortions despite easily available emergency contraceptive pills. Studies of women’s knowledge, attitudes and experience of the method] Lakartidningen 99:4730–4735
Stanford JB, Parnell TA, Boyle PC (2008) Outcomes from treatment of infertility with natural procreative technology in an Irish general practice. J Am Board Fam Med 21:375–384
Reddy UM, Wapner RJ, Rebar RW, Tasca RJ (2007) Infertility, assisted reproductive technology, and adverse pregnancy outcomes. Executive summary of a National Institute of Child Health and Human Development workshop. Obstet Gynecol 109:967–977
Harper JC, de Die-Smulder C, Goossen V et al (2008) ESHRE PGD consortium data collection VII: cycles from January to December 2004 with pregnancy follow-up to October 2005. Human Reproduction 23:741–755
UK National Government Statistics (2002). Contraception: by method used, 1976, 1986, 1995–96 and 1998–99. Social Trends. http://www.statistics.gov.uk/STATBASE/xsdataset.asp?vlnk=III&More=Y
Statistical Bulletin (2006) Abortion statistics, England and Wales. http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsStatistics/DH_075697
Department of Health (2007) Abortion statistics, England and Wales. http://www.wales.gov.uk/keypubstatisticsforwales/content/publication/health/2005/sdr138-2005/sdr138-2005.htm
Bajos N, Moreau C, Leridon H et al (2004) Pourquoi le nombre d’avortements n’a-t-il pas baissé en France depuis 30 ans? In “Population & Sociétés” 407:12. http://www.ined.fr/fichier/t_telechargement/3842/telechargement_fichier_fr_407.pdf
DREES (2006) Les interruptions volontaires de grossesse en 2004. “Etudes et Résultats” n. 522, September 2006
La salute riproduttiva. Sito del Ministero della salute http://www.ministerosalute.it/saluteDonna/paginaInternaMenuSaluteDonna.jsp?id=941&menu=statosalute
Puccetti R (2008) Contraccezione e aborto. In “L’uomo indesiderato”, Società Editrice Fiorentina 51–64
Caughey AB, Washington AE, Kuppermann M (2008) Perceived risk of prenatal diagnostic procedure-related miscarriage and Down syndrome among pregnant women. Am J Obstet Gynecol 198:333e1–8
Bellieni CV, Maffei M, Brogna A et al (2008) Consumerism in prenatal diagnosis? A local Italian study. Fetal Diagn Ther 24:29–34
PROMED GALILEO Battini L, Caruso A, Frigerio L et al (2008) Aborto farmacologico mediante mifepristone e misoprostol. Review. It J Gynæcol Obstet 20:43–68
WHO (2006) Essential medicines for reproductive health: guiding principles for their inclusion on national medicines lists. http://www.who.int/reproductive-health/publications/essential_medicines/emls_guidingprinciples.pdf
Gary MM, Harrison DJ (2006) Analysis of severe adverse events related to the use of mifepristone as an abortifacient. Ann Pharmcother 40:191–197
Sinave C, Le Templier G, Blouin D et al (2002) Toxic shock syndrome due to Clostridium sordellii: a dramatic postpartum and postabortion disease. Clin Infect Dis 35:1441–1443
Fischer M, Bhatnagar J, Guarner J et al (2005) Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion. NEJM 353:2352–2360
Morresi A, Roccella E (2006) La favola dell’aborto facile. Franco Angeli Editore, Milan
Henderson JT (2005) Safety of mifepristone abortions in clinical use. Contraception 72:175–178
Greene MF (2005) Fatal infections associated with mifepristone-induced abortion. NEJM 353:2317–2318
Miech RP (2005) Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii. Ann Pharmacother 39:1483–1488
Norme per la tutela sociale della maternità e sull’interruzione volontaria della gravidanza. Legge 22 maggio 1978, n. 194 (articolo 15)
WHO (2003) Safe abortion: technical and policy guidance for health systems. Geneva: WHO. (Table 4.2) www.who.int/repro-ductivehealth/publications/safe_abortion/safe_abortion.pdf
Comitato Nazionale per la Bioetica (2008) I grandi prematuri. Note bioetiche. 28 febbraio 2008
Consiglio Superiore di Sanità (2008) Comunicato n. 64. Raccomandazioni per le cure perinatali nelle età gestazionali estremamente basse. 4 marzo 2008
(2008) SIN Informa, Numero 3 Marzo 2008
Canadian Medical Association (1994) Management of the woman with threatened birth of an infant of extremely low gestational age. J Can Med Assoc 15:547–551
Doyle LW (2004) Victorian Infant Collaborative Study Group. Neonatal intensive care at borderline viability—is it worth it? Early Hum Dev 80:103–113
Lucey JF (2004) Fetal infants: the fate of 4172 infants with birth weights of 401 to 500 grams. The Vermont Oxford Network experience (1996–2000) Pediatrics 113:6
Costeloe K (1995) Survival and early morbidity of extremely preterm babies in England: changes since 1995. Arch Dis Child 93[Suppl1]:A33–A34
Marlow N, Wolke D, Bracewell MA, Samara M, for the EPICure Study Group (2005) Neurologic and developmental disability at six years of age after extremely preterm birth. NEJM 2005; 352:9–19
Hakansson S, Farooqi A, Holmgrem PA et al (2004) Proactive management promotes outcome in extremely preterm infants: a population-based comparison of two perinatal management strategies. Pediatrics 114:58–64
Steinmacher J (2008) Neurodevelopmental follow-up of very preterm infants after proactive treatment at a gestational age of >23 weeks. J Pediatr 152:771–776
Hack M, Fanaroff AA (2000) Outcomes of children of extremely low birthweight and gestational age in the 1990s. Semin Neonatol 5:89–106
Lorenz JM, Paneth N, Jetton JR et al (2001) Comparison of management strategies for extreme prematurity in New Jersey and the Netherlands: outcomes and resource expenditure. Pediatrics 108:1269–1274
Wilkinson AR, Ahluwalia J, Cole A et al (2009) The management of babies born extremely preterm at less than 26 weeks of gestation. A framework for clinical practice at the time of birth. Report of a working group. Arch Dis Child 94:F2–F5
Pignotti MS (2008) Perinatal care at the threshold of viability: an international comparison of practical guidelines for the treatment of extremely preterm births. Pediatrics 121:193–198
Ambalavanan N, Carlo WA, Shankaran S et al (2006) National Institute of Child Health and Human Development Neonatal Research Network. Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy. Pediatrics 118:2084–2093
Costeloe K, Hennessy E, Gibson AT et al for the EPICure Study Group (2000) The EPICure Study: outcomes in discharge from hospital for infants born at the threshold of viability. Pediatrics 106:659–671
Macfarlane PI (2003) Non-viable delivery at 20–23 weeks gestation: observations and signs of life after birth. Arch Dis Child Fetal Neonatal Ed 88:F199–F202
WHO (1992) International statistical classification of diseases and related health problems. Tenth revision. Geneva: WHO, 1;1235, para 3.1
Sauve RS, Robertson C, Etches P et al (1998) Before viability: a geographically based outcome study of infants weighing 500 grams or less at birth. Pediatrics 101:438–445
Lorenz JM (2000) Survival of the extremely preterm infant in North America in the 1990s. Clin Perinatol 27:225–262
Kamoji VM, Dorling JS, Manktelow BN et al (2006) Extremely growth-retarded infants: is there a viability centile? Pediatrics 118:758–763
Serenius F, Ewald U, Farooqi A et al (2004) Short-term outcome after active perinatal management at 23–25 weeks of gestation. A study from two Swedish tertiary care centres. Part 2: Infant survival. Acta Paediatr 93:1081–1089
http://www.timesonline.co.uk/article/0,,2087-1892696_1,00.html
Garne E, Loane M, Dolk H et al (2005) Prenatal diagnosis of severe structural congenital malformations in Europe. Ultrasound Obstet Gynecol 25:6–11
Anand KJ, Aranda JV, Berde CB et al (2006) Summary proceedings from the neonatal pain-control group. Pediatrics 117:S9–S22
Van Reempts P, Gortner L, Milligan D et al for the MOSAIC Research Group (2007) Characteristics of neonatal units that care for very preterm infants in Europe: results from the MOSAIC study. Pediatrics 120:e815–e825
Oishi M, Nishida H, Sasaki T (1997) Japanese experience with micropremies weighing less than 600 grams born between 1984 to 1993. Pediatrics 99:E7
Janvier A, Leblanc I, Barrington KJ (2008) The best-interest standard is not applied for neonatal resuscitation decisions. Pediatrics 121:963–969
Kaempf JW, Tomlinson M, Arduza C et al (2006) Medical staff guidelines for periviability pregnancy counseling and medical treatment of extremely premature infants. Pediatrics 117:22–29
Documento neonatologi italiani su Diagnosi prenatale: “Accesso consapevole alla diagnosi prenatale” 22 maggio 2008 http://www.medicinaepersona.org/resources/argomento/N118416e615ec8a70fa7/N118416e615ec8a70fa7/accesso_consapevole_alla_diagnosi_prenatale.pdf
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Isimbaldi, C., Vergani, P., Migliaro, G. et al. Ethical considerations on the beginning of life. J Med Pers 7, 91–100 (2009). https://doi.org/10.1007/s12682-009-0021-2
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DOI: https://doi.org/10.1007/s12682-009-0021-2