Fig. 4
From: Decoding high mobility group A2 protein expression regulation and implications in human cancers
The LIN28-Let7-HMGA2 axis, which controls HMGA2 levels. LIN28A&B inhibit the formation of mature Let-7 miRNAs and thus increase the HMGA2 levels, as mature Let-7 miRNAs leads either to the cleavage and degradation of HMGA2 mRNA, or to block the HMGA2 mRNA translation