Abstract
Objectives
Psychological and neural evidence suggests that negative attitudes toward stigmatized individuals arise in part from failures to perceive them as social targets. Here, we tested whether experimentally upregulating neural regions involved in social cognition would predict subsequent decreases in bias toward stigmatized individuals (i.e., people who use substances).
Methods
Participants underwent fMRI while completing either a lovingkindness intervention task or a control task, and each task was reinforced via daily text messages for a month following the one-time fMRI scan. Changes in implicit bias against stigmatized individuals were measured by Implicit Association Tests.
Results
The lovingkindness intervention task, compared with a control task, elicited greater baseline activity in the right temporoparietal junction (RTPJ), implicated in mentalizing, or the process of making inferences about others’ mental states. The lovingkindness task compared with the control task also produced marginal decreases in bias over the month of the intervention. Individual differences in initial RTPJ activity at baseline during the fMRI intervention tasks further predicted improved implicit attitudes toward stigmatized individuals a month later.
Conclusions
The current study suggests that individual differences in people’s tendency to engage brain regions that support taking others’ perspectives are associated with greater changes in bias reduction over time. It is possible that strategies that upregulate mentalizing activity, such as lovingkindness training and other strategies that increase social cognitive processing, may be effective in shifting people’s biases against stigmatized individuals.
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References
Ahern, J., Stuber, J., & Galea, S. (2007). Stigma, discrimination and the health of illicit drug users. Drug and Alcohol Dependence, 88(2-3), 188–196.
Balleine, B. W., Delgado, M. R., & Hikosaka, O. (2007). The role of the dorsal striatum in reward and decision-making. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 27(31), 8161–8165.
Bartra, O., McGuire, J. T., & Kable, J. W. (2013). The valuation system: a coordinate-based meta-analysis of BOLD fMRI experiments examining neural correlates of subjective value. NeuroImage, 76, 412–427.
Bodenhausen, G. V., Kramer, G. P., & Süsser, K. (1994). Happiness and stereotypic thinking in social judgment. Journal of Personality and Social Psychology, 66(4), 621.
Boysen, G. A., Vogel, D. L., & Madon, S. (2006). A public versus private administration of the implicit association test. European Journal of Social Psychology, 36(6), 845–856.
Brett, M., Anton, J. L., Valabregue, R., & Poline, J. B. (2002). Region of interest analysis using the MarsBar toolbox for SPM 99. NeuroImage, 16(2), S497.
Burns, S. M., Barnes, L. N., Katzman, P. L., Ames, D. L., Falk, E. B., & Lieberman, M. D. (2018). A functional near infrared spectroscopy (fNIRS) replication of the sunscreen persuasion paradigm. Social Cognitive and Affective Neuroscience, 13(6), 628–636.
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002). Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neuroscience and Biobehavioral Reviews, 26(3), 321–352.
Cheon, B. K., Im, D. M., Harada, T., Kim, J. S., Mathur, V. A., Scimeca, J. M., Parrish, T. B., Park, H. W., & Chiao, J. Y. (2011). Cultural influences on neural basis of intergroup empathy. NeuroImage, 57(2), 642–650.
Chua, H. F., Ho, S. S., Jasinska, A. J., Polk, T. A., Welsh, R. C., Liberzon, I., & Strecher, V. J. (2011). Self-related neural response to tailored smoking-cessation messages predicts quitting. Nature Neuroscience, 14(4), 426–427.
Cikara, M., Eberhardt, J. L., & Fiske, S. T. (2011). From agents to objects: sexist attitudes and neural responses to sexualized targets. Journal of Cognitive Neuroscience, 23(3), 540–551.
Cohen, G. L., & Sherman, D. K. (2014). The psychology of change: self-affirmation and social psychological intervention. Annual Review of Psychology, 65, 333–371.
Connor, P., Sarafidis, V., Zyphur, M. J., Keltner, D., & Chen, S. (2019). Income inequality and White-on-Black racial bias in the United States: evidence from Project Implicit and Google Trends. Psychological Science, 30(2), 205–222.
Corbetta, M., & Shulman, G. L. (2002). Control of goal-directed and stimulus-driven attention in the brain. Nature Reviews. Neuroscience, 3(3), 201–215. https://doi.org/10.1038/nrn755.
Crisp, R. J., Stathi, S., Turner, R. N., & Husnu, S. (2009). Imagined intergroup contact: theory, paradigm and practice. Social and Personality Psychology Compass, 3(1), 1–18. https://doi.org/10.1111/j.1751-9004.2008.00155.x.
Cuddy, A. J. C., Fiske, S. T., & Glick, P. (2008). Warmth and competence as universal dimensions of social perception: the stereotype Content Model and the BIAS Map. In Advances in Experimental Social Psychology (Vol. 40, pp. 61–149). Academic Press, DOI: https://doi.org/10.1097/PSN.0b013e31818ea7ca.
Dovidio, J. F., Gaertner, S. L., Isen, A. M., & Lowrance, R. (1995). Group representations and intergroup bias: positive affect, similarity, and group size. Personality & Social Psychology Bulletin, 21(8), 856–865.
Dufour, N., Redcay, E., Young, L., Mavros, P. L., Moran, J. M., Triantafyllou, C., Gabrieli, J. D. E., & Saxe, R. (2013). Similar brain activation during false belief tasks in a large sample of adults with and without autism. PLoS One, 8(9), e75468. https://doi.org/10.1371/journal.pone.0075468.
Dunn, J., & Schweitzer, M. E. (2005). Why good employees make unethical decisions: the role of reward systems, organizational culture, and managerial oversight. Managing Organizational Deviance, 39–68.
Falk, E. B., Berkman, E. T., Mann, T., Harrison, B., & Lieberman, M. D. (2010). Predicting persuasion-induced behavior change from the brain. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30(25), 8421–8424.
Falk, E. B., Berkman, E. T., Whalen, D., & Lieberman, M. D. (2011). Neural activity during health messaging predicts reductions in smoking above and beyond self-report. Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association, 30(2), 177–185.
Falk, E. B., O’Donnell, M. B., Cascio, C. N., Tinney, F., Kang, Y., Lieberman, M. D., Taylor, S. E., An, L., Resnicow, K., & Strecher, V. J. (2015). Self-affirmation alters the brain’s response to health messages and subsequent behavior change. Proceedings of the National Academy of Sciences, 112(7), 1977–1982.
Frith, U., & Frith, C. D. (2003). Development and neurophysiology of mentalizing. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 358(1431), 459–473.
Frith, C. D., & Frith, U. (2006). The neural basis of mentalizing. Neuron, 50(4), 531–534.
Galante, J., Galante, I., Bekkers, M. J., & Gallacher, J. (2014). Effect of kindness-based meditation on health and well-being: a systematic review and meta-analysis. Journal of Consulting and Clinical Psychology, 82(6), 1101–1114.
Galinsky, A. D., & Ku, G. (2004). The effects of perspective-taking on prejudice: the moderating role of self-evaluation. Personality & Social Psychology Bulletin, 30(5), 594–604.
Galinsky, A. D., Maddux, W. W., Gilin, D., & White, J. B. (2008). Why it pays to get inside the head of your opponent: the differential effects of perspective taking and empathy in negotiations. Psychological Science, 19(4), 378–384.
Greenwald, A. G., Nosek, B. A., & Banaji, M. R. (2003). Understanding and using the implicit association test: I. An improved scoring algorithm. Journal of Personality and Social Psychology, 85(2), 197–216.
Grossman, E. D., Blake, R., & Kim, C. Y. (2004). Learning to see biological motion: brain activity parallels behavior. Journal of Cognitive Neuroscience, 16(9), 1669–1679.
Harris, L. T., & Fiske, S. T. (2011). Perceiving humanity or not: a social neuroscience approach to dehumanized perception (pp. 123–134). Social Neuroscience: Toward Understanding the Underpinnings of the Social Mind. https://doi.org/10.1021/ja108575t.
Husnu, S., & Crisp, R. J. (2015). Perspective-taking mediates the imagined contact effect. International Journal of Intercultural Relations: IJIR, 44, 29–34.
Hutcherson, C. A., Seppala, E. M., & Gross, J. J. (2008). Loving-kindness meditation increases social connectedness. Emotion, 8(5), 720–724. https://doi.org/10.1037/a0013237.
Isbell, L. M. (2004). Not all happy people are lazy or stupid: evidence of systematic processing in happy moods. Journal of Experimental Social Psychology, 40(3), 341–349.
Islam, M. R., & Hewstone, M. (1993). Dimensions of contact as predictors of intergroup anxiety, perceived out-group variability, and out-group attitude: an integrative model. Personality & Social Psychology Bulletin, 19(6), 700–710.
Johnson, K. J., & Fredrickson, B. L. (2005). “We all look the same to me”: positive emotions eliminate the own-race bias in face recognition. Psychological Science, 16(11), 875–881.
Kang, Y. (2018). Examining interpersonal self-transcendence as a potential mechanism linking meditation and social outcomes. Current Opinion in Psychology, 28, 115–119.
Kang, Y., Gray, J. R., & Dovidio, J. F. (2014). The nondiscriminating heart: lovingkindness meditation training decreases implicit intergroup bias. Journal of Experimental Psychology. General, 143(3), 1306–1313. https://doi.org/10.1037/a0034150.
Kang, Y., Cooper, N., Pandey, P., Scholz, C., O’Donnell, M. B., Lieberman, M. D., Taylor, S. E., Strecher, V. J., Dal Cin, S., Konrath, S., Polk, T. A., Resnicow, K., An, L., & Falk, E. B. (2018). Effects of self-transcendence on neural responses to persuasive messages and health behavior change. Proceedings of the National Academy of Sciences of the United States of America, 115(40), 9974–9979.
Kanwisher, N., McDermott, J., & Chun, M. M. (1997). The fusiform face area: a module in human extrastriate cortex specialized for face perception. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 17(11), 4302–4311.
Klimecki, O. M., Leiberg, S., Ricard, M., & Singer, T. (2014). Differential pattern of functional brain plasticity after compassion and empathy training. Social Cognitive and Affective Neuroscience, 9(6), 873–879. https://doi.org/10.1093/scan/nst060.
Kreplin, U., Farias, M., & Brazil, I. A. (2018). The limited prosocial effects of meditation: a systematic review and meta-analysis. Scientific Reports, 8, (1), 2403.
Lang, P. J., Bradley, M. M., & Cuthbert, B. N. (1997). International affective picture system (IAPS): technical manual and affective ratings. NIMH Center for the Study of Emotion and Attention, 39–58.
Lloyd, C. (2013). The stigmatization of problem drug users: a narrative literature review. Drugs: Education, Prevention and Policy, 20(2), 85–95.
Luberto, C. M., Shinday, N., Song, R., Philpotts, L. L., Park, E. R., Fricchione, G. L., & Yeh, G. Y. (2018). A systematic review and meta-analysis of the effects of meditation on empathy, compassion, and prosocial behaviors. Mindfulness, 9(3), 708–724. https://doi.org/10.1007/s12671-017-0841-8.
Luoma, J. B., Twohig, M. P., Waltz, T., Hayes, S. C., Roget, N., Padilla, M., & Fisher, G. (2007). An investigation of stigma in individuals receiving treatment for substance abuse. Addictive Behaviors, 32(7), 1331–1346.
Mascaro, J. S., Rilling, J. K., Negi, L. T., & Raison, C. L. (2013). Pre-existing brain function predicts subsequent practice of mindfulness and compassion meditation. NeuroImage, 69, 35–42.
Mathur, V. A., Harada, T., Lipke, T., & Chiao, J. Y. (2010). Neural basis of extraordinary empathy and altruistic motivation. NeuroImage, 51(4), 1468–1475.
McCarthy, G., Puce, A., Gore, J. C., & Allison, T. (1997). Face-specific processing in the human fusiform gyrus. Journal of Cognitive Neuroscience, 9(5), 605–610. https://doi.org/10.1162/jocn.1997.9.5.605.
Oswald, F. L., Mitchell, G., Blanton, H., Jaccard, J., & Tetlock, P. E. (2013). Predicting ethnic and racial discrimination: a meta-analysis of IAT criterion studies. Journal of Personality and Social Psychology, 105(2), 171–192.
Paolini, S., Hewstone, M., Cairns, E., & Voci, A. (2004). Effects of direct and indirect cross-group friendships on judgments of Catholics and Protestants in Northern Ireland: the mediating role of an anxiety-reduction mechanism. Personality & Social Psychology Bulletin, 30(6), 770–786.
Parks, S., Birtel, M. D., & Crisp, R. J. (2014). Evidence that a brief meditation exercise can reduce prejudice toward homeless people. Social Psychology, 45(6), 458–465.
Peirce, J. W. (2007). PsychoPy—psychophysics software in Python. Journal of Neuroscience Methods, 162(1), 8–13.
Richeson, J. A., Baird, A. A., Gordon, H. L., Heatherton, T. F., Wyland, C. L., Trawalter, S., & Shelton, J. N. (2003). An fMRI investigation of the impact of interracial contact on executive function. Nature Neuroscience, 6(12), 1323–1328. https://doi.org/10.1038/nn1156.
Rilling, J. K., Dagenais, J. E., Goldsmith, D. R., Glenn, A. L., & Pagnoni, G. (2008). Social cognitive neural networks during in-group and out-group interactions. NeuroImage, 41(4), 1447–1461.
Saxe, R., & Kanwisher, N. (2003). People thinking about thinking people: the role of the temporo-parietal junction in “theory of mind”. NeuroImage, 19(4), 1835–1842.
Saxe, R., & Wexler, A. (2005). Making sense of another mind: the role of the right temporo-parietal junction. Neuropsychologia, 43(10), 1391–1399.
Scholz, J., Triantafyllou, C., Whitfield-Gabrieli, S., Brown, E. N., & Saxe, R. (2009). Distinct regions of right temporo-parietal junction are selective for theory of mind and exogenous attention. PLoS One, 4(3), e4869. https://doi.org/10.1371/journal.pone.0004869.
Schultz, R. T., Grelotti, D. J., Klin, A., Kleinman, J., Van der Gaag, C., Marois, R., & Skudlarski, P. (2003). The role of the fusiform face area in social cognition: implications for the pathobiology of autism. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 358(1430), 415–427. https://doi.org/10.1098/rstb.2002.1208.
Sherman, D. K., & Cohen, G. L. (2006). The psychology of self-defense: self-affirmation theory. In D. K. Sherman & G. L. Cohen (Eds.), Advances in experimental social psychology (Vol. 38, pp. 183–242). San Diego: Academic Press.
Simmonds, L., & Coomber, R. (2009). Injecting drug users: a stigmatised and stigmatising population. The International Journal on Drug Policy, 20(2), 121–130.
Singer, T., & Klimecki, O. M. (2014). Empathy and compassion. Current Biology: CB, 24(18), R875–R878.
Stell, A. J., & Farsides, T. (2016). Brief loving-kindness meditation reduces racial bias, mediated by positive other-regarding emotions. Motivation and Emotion, 40(1), 140–147.
Todd, A. R., Bodenhausen, G. V., Richeson, J. A., & Galinsky, A. D. (2011). Perspective taking combats automatic expressions of racial bias. Journal of Personality and Social Psychology, 100(6), 1027–1042.
van Olphen, J., Eliason, M. J., Freudenberg, N., & Barnes, M. (2009). Nowhere to go: how stigma limits the options of female drug users after release from jail. Substance Abuse Treatment, Prevention, and Policy, 4, 10.
Van Overwalle, F. (2009). Social cognition and the brain: a meta-analysis. Human Brain Mapping, 30(3), 829–858.
Vescio, T. K., Sechrist, G. B., & Paolucci, M. P. (2003). Perspective taking and prejudice reduction: the mediational role of empathy arousal and situational attributions. European Journal of Social Psychology, 33(4), 455–472. https://doi.org/10.1002/ejsp.163.
Vezich, I. S., Katzman, P. L., Ames, D. L., Falk, E. B., & Lieberman, M. D. (2017). Modulating the neural bases of persuasion: why/how, gain/loss, and users/non-users. Social Cognitive and Affective Neuroscience, 12(2), 283–297. https://doi.org/10.1093/scan/nsw113.
Voci, A., & Hewstone, M. (2003). Intergroup contact and prejudice toward immigrants in Italy: the mediational role of anxiety and the moderational role of group salience. Group Processes & Intergroup Relations: GPIR, 6(1), 37–54.
Wallmark, E., Safarzadeh, K., Daukantaitė, D., & Maddux, R. E. (2013). Promoting altruism through meditation: an 8-week randomized controlled pilot study. Mindfulness, 4(3), 223–234. https://doi.org/10.1007/s12671-012-0115-4.
Wang, A. L., Ruparel, K., Loughead, J. W., Strasser, A. A., Blady, S. J., Lynch, K. G., Romer, D., Cappella, J. N., Lerman, C., & Langleben, D. D. (2013). Content matters: neuroimaging investigation of brain and behavioral impact of televised anti-tobacco public service announcements. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 33(17), 7420–7427. https://doi.org/10.1523/JNEUROSCI.3840-12.2013.
Waugh, C. E., & Fredrickson, B. L. (2006). Nice to know you: positive emotions, self–other overlap, and complex understanding in the formation of a new relationship. The Journal of Positive Psychology, 1(2), 93–106. https://doi.org/10.1080/17439760500510569.
Weng, H. Y., Fox, A. S., Shackman, A. J., Stodola, D. E., Caldwell, J. Z. K., Olson, M. C., Rogers, G. M., & Davidson, R. J. (2013). Compassion training alters altruism and neural responses to suffering. Psychological Science, 24(7), 1171–1180.
Acknowledgments
We thank Nicole Cooper, Christin Scholz, Prateekshit Pandey, Alison Elliott, and Elizabeth Beard for research assistance, Matthew Brook O’Donnell for assistance in data analysis, Bruce Doré and Emile Bruneau for the helpful feedback, and the staff of the University of Pennsylvania fMRI Center for support and assistance.
Funding
This research was supported by the NIH New Innovator Award 1DP2DA03515601 (PI, E.B.F), NIH/National Cancer Institute Grant 1R01CA180015-01 (PI, E.B.F), and HopeLab (PIs, E.B.F, Y.K).
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YK designed the research, performed research, analyzed data, and wrote the paper. EBF designed the research, wrote the paper, and oversaw the project.
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The study was approved by the University of Pennsylvania Institutional Review Board.
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This study used a subset of a larger dataset from a study that examined an orthogonal question of health behavior change (reported in Kang et al. 2018). No prior report examined the implicit attitudes toward stigmatized individuals that are the focus of the current manuscript. We thank Nicole Cooper, Christin Scholz, Prateekshit Pandey, Alison Elliott, and Elizabeth Beard for research assistance, Matthew Brook O’Donnell for assistance in data analysis, Bruce Doré and Emile Bruneau for helpful feedback, and the staff of the University of Pennsylvania fMRI Center for support and assistance. This research was supported by NIH New Innovator Award 1DP2DA03515601 (PI, E.B.F), NIH/National Cancer Institute Grant 1R01CA180015-01 (PI, E.B.F) and HopeLab (PIs, E.B.F, Y.K).
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Kang, Y., Falk, E.B. Neural Mechanisms of Attitude Change Toward Stigmatized Individuals: Temporoparietal Junction Activity Predicts Bias Reduction. Mindfulness 11, 1378–1389 (2020). https://doi.org/10.1007/s12671-020-01357-y
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DOI: https://doi.org/10.1007/s12671-020-01357-y