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Mindfulness-Based Interventions for Psoriasis: a Randomized Controlled Trial

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Psoriasis is a chronic, inflammatory skin disease that has a profound psychological impact. Despite the pertinence of mental health difficulties to psoriasis, the literature is devoid of empirical support for the long-term beneficial effects of mindfulness-based interventions (MBIs). This study aimed to determine the comparative efficacy of mindfulness-based cognitive therapy (MBCT), mindfulness-based self-compassion therapy (MBSCT), and self-help MBSCT (MBSCT-SH) relative to treatment-as-usual (TAU) in improving the long-term psychological and physical outcomes of individuals with psoriasis. Ninety-four adults with mild to moderate psoriasis were randomly assigned to TAU (n = 22) or TAU combined with MBCT (n = 25), MBSCT (n = 25), or MBSCT-SH (n = 22). Participants completed assessments of psychological well-being, psoriasis symptom burden, and quality of life at pre- and post-treatment as well as 6- and 12-month follow-up. Although participants reported that the MBIs were beneficial, no statistically significant differences were found on psychological well-being, psoriasis symptom burden, or quality of life relative to TAU alone at post-treatment, 6- or 12-month follow-up. The development of our understanding of differences in the effects of MBIs for disparate disease groups is instrumental to realizing the therapeutic potential of MBIs.

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The authors would like to thank Drs. Paul Collins and Aoife Lally for their help with the study.


This study was funded by AbbVie Ltd.

Author information

Authors and Affiliations



Paul D’Alton: Study design, intervention delivery, data collection, statistical analysis, and manuscript preparation

Louise Kinsella: Study design, intervention delivery, and data collection

Orla Walsh: Study design and data collection

Cheryl Sweeney: Study design and data collection

Irene Timoney: Study design and data collection

Maeve Lynch: Study design and data collection

Martin O’Connor: Statistical analysis and manuscript preparation

Brian Kirby: Study design, data collection, statistical analysis, and manuscript preparation

Corresponding author

Correspondence to Paul D’Alton.

Ethics declarations

Ethical Approval

Ethical approval for the study was provided by St. Vincent’s Healthcare Group Ethics and Medical Research Committee. All procedures performed were in accordance with the ethical standards of the institutional and/or national research committee and with the Declaration of Helsinki (World Medical Association, 2013) or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Conflict of Interest

The authors declare that they have no conflict of interest.

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D’Alton, P., Kinsella, L., Walsh, O. et al. Mindfulness-Based Interventions for Psoriasis: a Randomized Controlled Trial. Mindfulness 10, 288–300 (2019).

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