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Soliton Dynamics and DDMC/sncRNAs Complex for Epigenetic Change to Normal Cells in TME

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Abstract

Complex by DDMC/sncRNAs(a-miR-155, piR-30074, and miR-125b) have shown the full recovery of mice from virus-induced sarcoma after treatment by changing to normal cells from cancer cells. With kinetic of inhibiting tumor growth, the difference from control \(\varvec{(mm^2)}\) of one intravenous injection and two intravenous injections is the same curvature and rate so that this is a soliton wave having a permanent form (velocity, shape) such as one faster soliton overcoming another one without any changing shape in the case of two intravenous injections. Signal transduction for this DDS must be Hill-type sigmoids following the nonlinear Schrödinger model by transfer of energy, sine-Gordon soliton model by momentum, and Fisher KPP soliton model by mass transfer. We find out that the cell outlet/inlet response of DDMC/sncRNAs is more dependent on the soliton signal not losing energy and shape without jamming communication. The endoplasmic reticulum-mitochondrial \(\varvec{Ca^{2+}}\) fluxes induced by soliton to Chromosome in nuclear will take place epigenetic modifications on 5-position of cytosine (5mC) by TET enzymes and thymine DNA glycosylase (TDG) as an overall intracellular reaction. By soliton flow, the result shows the equations of quantum mechanics can be related to the epigenetic control with \(\varvec{Ca^{2+}}\) fluxes followed by “induced fit model” Hill equation S-shaped.

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Acknowledgements

We are deeply grateful to the late Prof. Terukiyo Hanafusa of Hiroshima University for his discussion of DDMC.

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Author notes

  1. Yasuhiko Onishi contributed equally to this work.

Authors and Affiliations

  1. SID ALEX GROUP Ltd, Kyselova, Prague, 1185/2, Czech Republic

    Oxana V. Klimenko

  2. Faculty of Welfare and Health Science, Oita University, Oita, 870-1192, Japan

    Rui-Cheng Ji

  3. Department of Infectious Disease Control, Faculty of Medicine, Oita University, Yufu, 879-5593, Oita, Japan

    Takashi Kobayashi

  4. Ryujyu Science Corporation, Kosora-cho, Seto, 489-0842, Aichi, Japan

    Masayasu Onishi & Yasuhiko Onishi

  5. Nagoya University Hospital, Tsurumai, Nagoya, 466-8560, Aichi, Japan

    Masaaki Mizuno

  6. Sakura General Hospital, Oguchi-cho, 480-0127, Aichi, Japan

    Jun Yoshida

  7. Department of Chemistry, Faculty of Medicine, Oita University, Yufu, 870-1192, Oita, Japan

    Naoji Kubota

  8. Hokkaido University International Institute for Zoonosis Control, North 20 West 10, Kita-ku, Sapporo, 001-0020, Hokkaido, Japan

    Yuki Eshita

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  1. Oxana V. Klimenko
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Contributions

YO designed and performed the data analysis, and wrote the manuscript. OK conducted the experiments, performed the data analysis, and wrote the manuscript. RJ, TK, MM, JY, Nk, and UE reviewed the manuscript. MO supervised the project.

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Correspondence to Yasuhiko Onishi.

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Klimenko, O.V., Ji, RC., Kobayashi, T. et al. Soliton Dynamics and DDMC/sncRNAs Complex for Epigenetic Change to Normal Cells in TME. BioNanoSci. (2023). https://doi.org/10.1007/s12668-023-01258-z

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