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Evaluation of Allergenic and Mutagenic Activity In Vivo of New Gas Hydrate and Corrosion Inhibitors Based on Waterborne Polyurethanes

Abstract

The development of environmentally friendly multifunctional additives is an urgent area of modern organic chemistry. In this work, some derivatives of waterborne polyurethanes as efficient dual-purpose gas hydrate and corrosion inhibitors were studied for their allergenic and mutagenic activity in vivo. Studies of the allergenic effect of polyurethane samples on guinea pigs, rats, and rabbits indicated that these compounds do not have a negative effect on the organism of laboratory animals and do not pose a mutagenic hazard at concentration of 1 wt%. However, these polymers had an allergenic effect on the tissues of laboratory animals in the area of their application at a concentration of 10 wt%. The results of this study provide reasonable evidence for application of waterborne polyurethanes as safe additives for humans and the environment at their optimum concentration (1 wt%) for inhibiting the formation of gas hydrates and corrosion in the oil and gas industry.

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Funding

This research was funded by RFBR and The Research Council of Norway according to the re-search project 20–55-20010.

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Contributions

Conceptualization: R. S. Pavelyev, M. A. Varfolomeev, L. R. Valiullin; methodology: R. S. Pavelyev, Rin. S. Mukhammadiev, Rish. S. Mukhammadiev, L. R. Valiullin; validation: R. S. Pavelyev, Rin. S. Mukhammadiev, Rish. S. Mukhammadiev, L. R. Valiullin, M. A. Varfolomeev; data curation: Rin. S. Mukhammadiev, Rish. S. Mukhammadiev; writing—original draft preparation: Rin. S. Mukhammadiev, Rish. S. Mukhammadiev; writing—review and editing, R. S. Pavelyev, M. A. Varfolomeev, L. R. Valiullin, Y. F. Zaripova; formal analysis: R. S. Pavelyev, Rin. S. Mukhammadiev, Rish. S. Mukhammadiev, L. R. Valiullin, M. A. Varfolomeev; investigation: Rin. S. Mukhammadiev, Rish. S. Mukhammadiev, R. S. Pavelyev, Y. F. Zaripova, L. R. Valiullin, O. V. Shlyamina, A. P. Glinushkin; resources: M. A. Varfolomeev; visualization: R. S. Pavelyev, Rin. S. Mukhammadiev, Rish. S. Mukhammadiev, L. R. Valiullin; supervision: M. A. Varfolomeev and L. R. Valiullin; project administration: R. S. Pavelyev and L. R. Valiullin; funding acquisition: M. A. Varfolomeev. All authors have read and agreed to the published version of the manuscript.

The study was carried out in accordance with the general European requirements for animals used in the experiment (Strasbourg, 1986) and was approved by the Ethics Commit-tee on the experimental use of laboratory animals of the researcher’s institution (order No. 251-p of 22 November, 2017).

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Correspondence to Mikhail A. Varfolomeev.

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Valiullin, L.R., Mukhammadiev, R.S., Mukhammadiev, R.S. et al. Evaluation of Allergenic and Mutagenic Activity In Vivo of New Gas Hydrate and Corrosion Inhibitors Based on Waterborne Polyurethanes. BioNanoSci. 12, 256–266 (2022). https://doi.org/10.1007/s12668-022-00945-7

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  • DOI: https://doi.org/10.1007/s12668-022-00945-7

Keywords

  • Environmental effects
  • Allergenic activity
  • Mutagenic activity
  • Kinetic hydrate inhibitor
  • Corrosion inhibitor
  • Waterborne polyurethane