The present paper aims to study the biological properties of a series of bicyclic monoterpene alcohols. Firstly, we tested the obtained compounds for fungicidal activity against clinical and reference strains of microscopic fungi. Next, we determined the minimum inhibitory concentration of these compounds comparing to other drugs widely used in practical medicine (fluconazole, terbinafine). At this stage, we found that ( −)-myrtenol (47 MIC and 23.5 μg/ml) exhibits the most promising activity against filamentous and yeast fungi, respectively. Then, we have studied the membrane-protective and antioxidant activities of the obtained compounds and found out that ( −)-cis-verbenol and ( −)-myrtenol exhibit the highest activity on the model of erythrocytes oxidative hemolysis. Interestingly, among all the studied bicyclic monoterpene alcohols, the alcohols of the pinane series have been found to be the most promising. The obtained results from the present study suggest that ( −)-myrtenol would be a leading compound for further studies in terms of possible practical application.
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This work was supported by the Russian Science Foundation, grant No 15–14-00046 and the Program of Competitive Growth of Kazan Federal University. The study of antifungal activity was conducted with the financial support of the charitable foundation of PJSC TATNEFT. The study of hemolytic and antioxidant activity was conducted with the financial support by the Ministry of Science and Higher Education of the Russian Federation (state assignment no. AAAA-A18-118011120004–5). The authors would like to thank the general director of PJSC TATNEFT Nail Maganov for his ongoing collaboration with our department.
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Nikitina, L.E., Lisovskaya, S.A., Startseva, V.A. et al. Biological Activity of Bicyclic Monoterpene Alcohols. BioNanoSci. 11, 970–976 (2021). https://doi.org/10.1007/s12668-021-00912-8