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Biological Activity of Bicyclic Monoterpene Alcohols

BioNanoScience volume 11, pages 970–976 (2021)Cite this article

Abstract

The present paper aims to study the biological properties of a series of bicyclic monoterpene alcohols. Firstly, we tested the obtained compounds for fungicidal activity against clinical and reference strains of microscopic fungi. Next, we determined the minimum inhibitory concentration of these compounds comparing to other drugs widely used in practical medicine (fluconazole, terbinafine). At this stage, we found that ( −)-myrtenol (47 MIC and 23.5 μg/ml) exhibits the most promising activity against filamentous and yeast fungi, respectively. Then, we have studied the membrane-protective and antioxidant activities of the obtained compounds and found out that ( −)-cis-verbenol and ( −)-myrtenol exhibit the highest activity on the model of erythrocytes oxidative hemolysis. Interestingly, among all the studied bicyclic monoterpene alcohols, the alcohols of the pinane series have been found to be the most promising. The obtained results from the present study suggest that ( −)-myrtenol would be a leading compound for further studies in terms of possible practical application.

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Funding

This work was supported by the Russian Science Foundation, grant No 15–14-00046 and the Program of Competitive Growth of Kazan Federal University. The study of antifungal activity was conducted with the financial support of the charitable foundation of PJSC TATNEFT. The study of hemolytic and antioxidant activity was conducted with the financial support by the Ministry of Science and Higher Education of the Russian Federation (state assignment no. AAAA-A18-118011120004–5). The authors would like to thank the general director of PJSC TATNEFT Nail Maganov for his ongoing collaboration with our department.

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Authors and Affiliations

  1. Kazan State Medical University, Butlerova St. 49, Kazan, 420012, Russian Federation

    Liliya E. Nikitina, Svetlana A. Lisovskaya, Valeriya A. Startseva, Olga V. Ostolopovskaya, Ilmir R. Gilfanov, Inna V. Fedyunina, Renad R. Khaliullin & Alexander G. Izmailov

  2. Kazan Federal University, Kremlevskaya St. 18, Kazan, 420008, Russian Federation

    Liliya E. Nikitina, Svetlana A. Lisovskaya, Olga V. Ostolopovskaya, Roman S. Pavelyev & Mohammed A. Khelkhal

  3. Kazan Scientific Research Institute of Epidemiology and Microbiology, Bolshaya Krasnaya St. 67, Kazan, 420015, Russian Federation

    Svetlana A. Lisovskaya

  4. Institute of Chemistry, Federal Research Center, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, Pervomayskaya St. 48, Syktyvkar, 167982, Russian Federation

    Larisa L. Frolova & Alexander V. Kutchin

  5. Institute of Biology, Komi Science Centre, Ural Branch of Russian Academy of Sciences, Kommunisticheskaya St. 28, Syktyvkar, 167982, Russian Federation

    Oksana G. Shevchenko

  6. Kazan National Research Technological University, K. Marksa St. 68, Kazan, 420015, Russian Federation

    Rustem F. Akhverdiev, Alexander V. Gerasimov & Ekaterina V. Abzaldinova

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  1. Liliya E. Nikitina
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  2. Svetlana A. Lisovskaya
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Correspondence to Liliya E. Nikitina.

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Nikitina, L.E., Lisovskaya, S.A., Startseva, V.A. et al. Biological Activity of Bicyclic Monoterpene Alcohols. BioNanoSci. 11, 970–976 (2021). https://doi.org/10.1007/s12668-021-00912-8

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