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Production and Characterization of Antimicrobial Electrospun Nanofibers Containing Polyurethane, Zirconium Oxide and Zeolite

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Abstract

In this study, electrospinning technique has been utilized to prepare composite nanofiber mats of polyurethane (PU)/zirconium dioxide (ZrO2) and PU/zeolite, consisted by antimicrobial properties. Tensile strength measurement test was performed for the mechanical analysis of the nanofibers. Scanning electron microscopy (SEM) were performed for displaying the morphological features of the fiber structure. XRD tests were performed for revealing the chemical structure. Antimicrobial tests were also performed to display antimicrobial effects of the produced materials. In vitro test was also performed to determine cytotoxicity and biocompatibility. The present PU/ZrO2 and PU/zeolite composite nanofibers resulted with improved mechanical properties and good antimicrobial properties against either their pure forms or other studies. Cell proliferation and viability also increased significantly with increase in zeolite and ZrO2 ratio. It is concluded that this composition provides a novel alternative as an antimicrobial material which can be suitable as a wound dressing or a coating material for various healthcare engineering applications.

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Acknowledgements

This study has been founded by BAPKO, Marmara University, grant no. FEN-B-080415-0117. Additionally, scanning electron microscopy analyses were possible due to EU funding grant POSCCE-A2-O2.2.1-2013-1/Priority Direction 2, Project No. 638/12.03.2014, code SMIS-CSNR 48652.

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Authors and Affiliations

  1. Advanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey

    Mehmet Onur Aydogdu, Alexandra Elena Oprea, Anton Ficai, Andrei Viorel Paduraru, Diana Georgiana Filip, Esra Altun, Nazmi Ekren, Faik Nuzhet Oktar & Oguzhan Gunduz

  2. Department of Metallurgical and Materials Engineering, Master of Science, Institute of Pure and Applied Sciences, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey

    Mehmet Onur Aydogdu & Esra Altun

  3. Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, București, Romania

    Alexandra Elena Oprea, Roxana Trusca, Adrian Vasile Surdu, Anton Ficai & Andrei Viorel Paduraru

  4. Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Lane, Sector 5, 77206, Bucharest, Romania

    Alina Maria Holban

  5. Department of Fetal and Adult Stem Cell Therapy, Institute of Cellular Biology and Pathology of Romanian Academy, “Nicolae Simionescu”, 8, B.P. Hasdeu, 050568, Bucharest, Romania

    Florin Iordache

  6. Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street No. 1-7, 011061, Bucharest, Romania

    Diana Georgiana Filip

  7. Department of Electric-Electronic Engineering, Faculty of Technology, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey

    Nazmi Ekren

  8. Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey

    Faik Nuzhet Oktar & Oguzhan Gunduz

Authors
  1. Mehmet Onur Aydogdu
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  2. Alexandra Elena Oprea
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  3. Roxana Trusca
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  4. Adrian Vasile Surdu
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  5. Anton Ficai
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  6. Alina Maria Holban
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  7. Florin Iordache
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  8. Andrei Viorel Paduraru
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  9. Diana Georgiana Filip
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  10. Esra Altun
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  11. Nazmi Ekren
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  12. Faik Nuzhet Oktar
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  13. Oguzhan Gunduz
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Corresponding author

Correspondence to Oguzhan Gunduz.

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Aydogdu, M.O., Oprea, A.E., Trusca, R. et al. Production and Characterization of Antimicrobial Electrospun Nanofibers Containing Polyurethane, Zirconium Oxide and Zeolite. BioNanoSci. 8, 154–165 (2018). https://doi.org/10.1007/s12668-017-0443-x

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  • DOI: https://doi.org/10.1007/s12668-017-0443-x

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