Production and Characterization of Antimicrobial Electrospun Nanofibers Containing Polyurethane, Zirconium Oxide and Zeolite
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In this study, electrospinning technique has been utilized to prepare composite nanofiber mats of polyurethane (PU)/zirconium dioxide (ZrO2) and PU/zeolite, consisted by antimicrobial properties. Tensile strength measurement test was performed for the mechanical analysis of the nanofibers. Scanning electron microscopy (SEM) were performed for displaying the morphological features of the fiber structure. XRD tests were performed for revealing the chemical structure. Antimicrobial tests were also performed to display antimicrobial effects of the produced materials. In vitro test was also performed to determine cytotoxicity and biocompatibility. The present PU/ZrO2 and PU/zeolite composite nanofibers resulted with improved mechanical properties and good antimicrobial properties against either their pure forms or other studies. Cell proliferation and viability also increased significantly with increase in zeolite and ZrO2 ratio. It is concluded that this composition provides a novel alternative as an antimicrobial material which can be suitable as a wound dressing or a coating material for various healthcare engineering applications.
KeywordsPolyurethane Zirconia Zeolite Electrospinning Nanofibers Antimicrobial activity
This study has been founded by BAPKO, Marmara University, grant no. FEN-B-080415-0117. Additionally, scanning electron microscopy analyses were possible due to EU funding grant POSCCE-A2-O2.2.1-2013-1/Priority Direction 2, Project No. 638/12.03.2014, code SMIS-CSNR 48652.
- 3.Kucinska-Lipka, J., Gubanska, I., Janik, H., & Sienkiewicz, M. (2015). M. Review: fabrication of polyurethane and polyurethane based composite fibres by the electrospinning technique for soft tissue engineering of cardiovascular system. Materials Science and Engineering: C, 46, 166–176.CrossRefGoogle Scholar
- 4.Tijing, L. D., Ruelo, M. T. G., Amarjargal, A., Pant, H. J., Park, C.-H., & Kim, C. S. (2012). One step fabrication of antibacterial silver nanoparticles poly ethylene oxide polyurethane bicomponent hybrid nanofibrous mat by dual spinneret electrospinning. Materials Chemistry and Physics, 134, 557–561.CrossRefGoogle Scholar
- 9.Tijing, L. D., Ruelo, M. T. G., Amarjargal, A., Pant, H. J., Park, C.-H., Kim, D. W., & Kim, C. S. (2014). Electrospun ZrO2 fibers obtained from polyvinyl alcohol/zirconium n-propoxide composite fibers processed through halide free sol–gel route using acetic acid as a stabilizer. Materials Letters, 115, 64–67.CrossRefGoogle Scholar
- 10.Hecht, K. (2010). Application of natural zeolites in medicine and cosmetology – ZEOMEDCOS (pp. 7–46). Baku London: SWB.Google Scholar
- 11.Pavelic K and Hadz ija M (2003) Medical Applications of Ruder Bosˇkovic’ Institute, Zagreb.Google Scholar
- 12.Lubasova, D., & Barbora, S. (2014). Antibacterial efficiency of nanofiber membranes with biologically active nanoparticles. Bali: International Conference on Agriculture, Biology and Environmental Sciences (ICABES'14).Google Scholar
- 14.Rădulescu, M., Andronescu, E., Holban, A. M., Vasile, B. S., Iordache, F., Mogoantă, L., Mogoșanu, G. D., Grumezescu, A. M., Georgescu, M., & Chifiriuc, M. C. (2016). Antimicrobial nanostructured bioactive coating based on Fe3O4 and patchouli oil for wound dressing. Metals, 6(5), 103.CrossRefGoogle Scholar
- 16.Powers, J. M., & Sakaguchi, R. L. (2006). Resin composite restorative material (p. 193). USA: Mosby Elsevier Craig's Restorative Dental Materials.Google Scholar
- 21.Chen, S., Ge, L., Mueller, A., Carlson, M. A., Teusink, M. J., Shuler, F. D., & Xie, J. (2017). Twisting electrospun nanofiber fine strips into functional sutures for sustained co-delivery of gentamicin and silver. Nanomedicine: Nanomedicine Nanotechnology Biology Medicine, 13, 1435–1445.CrossRefGoogle Scholar