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Plasticity of Mycoplasmas: Changes in the Genomic Profile, as well as in the Cellular and Vesicular Proteomes of the Acholeplasma laidlawii in Adapting the Bacterium to Different Environmental Conditions


For the first time as a result of the comparative analysis of proteomes of cells and extracellular vesicles, as well as the complete nucleotide sequence of Acholeplasma laidlawii cells under various conditions of growth of the mycoplasma, the evidence of a high level of plasticity of this bacterium, providing a rapid adaptation to stressors associated with the SOS response, was obtained. The battery of genes with targeted potential for the infekta control system using CRISPR tools was revealed.

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The work is performed according to the Russian Government Program of Competitive Growth of Kazan Federal University. This study was performed using the equipment of the Interdisciplinary Collective Use Center of the Kazan Federal University Center with state financial support from the Ministry of Education and Science of the Russian Federation (ID RFMEFI59414X0003), as well as the Russian Foundation for Basic Research (grant numbers 14-04-00883, 15-44-02594, 16-34-0066).

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Correspondence to A. A. Mouzykantov.

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Mouzykantov, A.A., Medvedeva, E.S., Malygina, T.Y. et al. Plasticity of Mycoplasmas: Changes in the Genomic Profile, as well as in the Cellular and Vesicular Proteomes of the Acholeplasma laidlawii in Adapting the Bacterium to Different Environmental Conditions. BioNanoSci. 7, 323–325 (2017).

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  • Mycoplasma
  • Plasticity
  • Genome
  • Proteome
  • Extracellular vesicles