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Differences in the Serum VEGF Are Not Associated with Differences in Cytokine Isoforms in Nephropathia Epidemica

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Abstract

Nephropathia epidemica (NE) is an acute zoonosis, caused by Puumala virus, belongs to genus Hantavirus. Disturbed hemostasis is characteristic for the NE, where signs of increased vascular permeability and bleeding are described at early stage of the disease. Although pathogenesis of vascular permeability remains unknown, the vascular endothelial growth factor (VEGF) was suggested to play role. There are several isoforms of VEGF based on the alternate splicing of the exon 6 and 7. These isoforms differ in ability to support endothelial cells proliferation and survival. The isoform VEGF165 promotes endothelial cell growth and remodeling, while the isoform VEGF121 lacks such effect. We have found increased level of VEGF in serum from NE cases. The VEGF isoform analysis revealed presence of only VEGF165, while isoform VEGF121 was absent. Therefore, we suggest that VEGF in serum of NE cases function to promote endothelial cells proliferation and vascular remodeling.

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Acknowledgments

This work was supported by the Russian Science Foundation grant 15-14-00016. The work is performed according to the Russian Government Program of Competitive Growth of Kazan Federal University and subsidy allocated to the Kazan Federal University for the state assignment in the sphere of scientific activities. Some of the experiments were conducted using the equipment of Interdisciplinary center for collective use of the Kazan Federal University supported by the Ministry of Education of Russia (ID RFMEFI59414X0003) and the Pharmaceutical Research and Education Center, Kazan Federal University, Kazan, Russia.

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Authors and Affiliations

  1. Kazan State Medical University, Kazan, Republic of Tatarstan, Russian Federation

    I. I. Salafutdinov, E. V. Martynova, S. F. Khaiboullina, V. A. Anokhin & A. A. Rizvanov

  2. Whittemore Peterson Institute, Reno, NV, USA

    S. F. Khaiboullina

  3. Kazan State Medical Academy, Kazan, Russian Federation

    V. G. Shakirova

Authors
  1. I. I. Salafutdinov
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  2. E. V. Martynova
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  3. S. F. Khaiboullina
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  4. V. A. Anokhin
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  5. V. G. Shakirova
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  6. A. A. Rizvanov
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Corresponding author

Correspondence to S. F. Khaiboullina.

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Salafutdinov, I.I., Martynova, E.V., Khaiboullina, S.F. et al. Differences in the Serum VEGF Are Not Associated with Differences in Cytokine Isoforms in Nephropathia Epidemica. BioNanoSci. 7, 313–315 (2017). https://doi.org/10.1007/s12668-016-0340-8

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  • DOI: https://doi.org/10.1007/s12668-016-0340-8

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