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Use of Gene-Activated Demineralized Bone Allograft in the Therapy of Ulnar Pseudarthrosis. Case Report

Abstract

This paper presents a clinical case of successful ulnar pseudarthrosis treatment using a gene-activated bone allograft containing VEGF (vascular endothelial growth factor) and BMP2 (bone morphogenetic protein 2) in the form of a multicystron plasmid. Demineralized bone matrix with applied recombinant plasmid DNA was grafted into the bone defect using the classical open surgical approach. Two months after the surgery, the patient noticed the disappearance of pain including pain during activity. On X-rays of ulna, signs of union in the form of callus formation were found.

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Acknowledgments

The work is performed according to the Russian Government Program of Competitive Growth of the Kazan Federal University and subsidy allocated to the Kazan Federal University for the state assignment in the sphere of scientific activities. Some of the experiments were conducted using the equipment of Interdisciplinary Center for collective use of the Kazan Federal University supported by the Ministry of Education of Russia (ID RFMEFI59414X0003) and the Pharmaceutical Research and Education Center, Kazan (Volga Region) Federal University, Kazan, Russia. The work was supported by the Ministry of Health Care of Tatarstan Republic.

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Correspondence to Ruslan Masgutov.

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Written informed consent of the patient to the surgery was obtained. The intervention was carried out with the permission of the Ethics Committee within the context of the topic “Improvement of treatment methods for injuries and diseases of large joints” of the State autonomous health care institution “Republican clinical hospital of the Ministry of health care of the Republic of Tatarstan”.

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The authors declare that they have no conflicts of interest.

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Masgutov, R., Chekunov, M., Zhuravleva, M. et al. Use of Gene-Activated Demineralized Bone Allograft in the Therapy of Ulnar Pseudarthrosis. Case Report. BioNanoSci. 7, 194–198 (2017). https://doi.org/10.1007/s12668-016-0325-7

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  • DOI: https://doi.org/10.1007/s12668-016-0325-7

Keywords

  • Ulnar pseudarthrosis
  • Graft
  • VEGF
  • BMP2