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NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles

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Fluvastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. It lowers the overall blood cholesterol level, which is responsible for coronary artery diseases. Conformational features of fluvastatin in water solution were determined. NMR experiments showed that fluvastatin form molecular complex with model cell membrane. It intercalates into membrane surface by its aromatic part. Intermolecular distances between dodecylphosphocholine micelles and fluvastatin nuclei were calculated.

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  1. Davidson, H. (1994). Fluvastatin long term extension trial (FLUENT): summary of efficacy and safety. The American Journal of Medicine, 96(6), S41–S44.

    Article  Google Scholar 

  2. Peters, T. K., Jewitt-Harris, J., Mehra, M., Muratti, E. N. (1993). Safety and tolerability of fluvastatin with concomitant use of antihypertensive agents: an analysis of a clinical trial database. American Journal of Hypertension, 6, S346–S352.

    Article  Google Scholar 

  3. Davidson, M. H. (2004). Comparative effects of lipid-lowering therapies. Progress in Cardiovascular Diseases, 47, 73–104.

    Article  Google Scholar 

  4. Lindahl, A., Sandstrom, R., Ungell, A.-L., Abrahamsson, B., Knutson, T. W., Knutson, L., et al. (1996). Jejunal permeability and hepatic extraction of fluvastatin in humans. Clinical Pharmacology and Therapeutics, 60, 493–503.

    Article  Google Scholar 

  5. Mason, R. P., Walter, M. F., Day, C. A., Jacob, R. F. (2005). Intermolecular differences of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors contribute to distinct pharmacologic and pleiotropic actions. The American Journal of Cardiology, 96, 11–23.

    Article  Google Scholar 

  6. Rakhmatullin, I. Z., Galiullina, L. F., Klochkova, E. A., Latfullin, I. A., Aganov, A. V., Klochkov, V. V. (2016). Structural studies of pravastatin and simvastatin and their complexes with SDS micelles by NMR spectroscopy. Journal of Molecular Structure, 1105, 25–29.

    Article  Google Scholar 

  7. Galiullina, L. F., Rakhmatullin, I. Z., Klochkova, E. A., Aganov, A. V., Klochkov, V. V. (2015). Structure of pravastatin and its complex with sodium dodecyl sulfate micelles studied by NMR spectroscopy. Magnetic Resonance in Chemistry, 53(2), 110–114.

    Article  Google Scholar 

  8. Kallik, D. A., Tessmer, M. R., Watts, C. R., Li, C.-Y. (1995). The use of dodecylphosphocholine micelles in solution NMR. Journal of Magnetic Resonance. Series B, 109, 60–65.

    Article  Google Scholar 

  9. Larocque, G., Arnold, A. A., Chartrand, E., Mouget, Y., Marcotte, I. (2010). Effect of sodium bicarbonate as a pharmaceutical formulation excipient on the interaction of fluvastatin with membrane phospholipids. European Biophysics Journal, 39, 1637–1647.

    Article  Google Scholar 

  10. Ali, S. M., Upadhyay, S. K., Maheshwari, A., Koketsu, M. (2006). Complexation of fluvastatin sodium with β-cyclodextrin: NMR spectroscopy study in solution. Journal of Inclusion Phenomena, 55, 325–328.

    Article  Google Scholar 

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This work was supported by the Russian Foundation for Basic Research (grant 16-33-60014). The work was also performed according to the Russian Government Program of Competitive Growth of Kazan Federal University.

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Correspondence to V. V. Klochkov.

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Galiullina, L.F., Aganova, O.V., Latfullin, I.A. et al. NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles. BioNanoSci. 6, 352–354 (2016).

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