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NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles

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Abstract

Fluvastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. It lowers the overall blood cholesterol level, which is responsible for coronary artery diseases. Conformational features of fluvastatin in water solution were determined. NMR experiments showed that fluvastatin form molecular complex with model cell membrane. It intercalates into membrane surface by its aromatic part. Intermolecular distances between dodecylphosphocholine micelles and fluvastatin nuclei were calculated.

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Acknowledgments

This work was supported by the Russian Foundation for Basic Research (grant 16-33-60014). The work was also performed according to the Russian Government Program of Competitive Growth of Kazan Federal University.

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Authors and Affiliations

  1. Laboratory of NMR, Kazan Federal University, 16a Kremlevskaya str, Kazan, 420008, Russia

    L. F. Galiullina, O. V. Aganova, I. A. Latfullin, G. S. Musabirova, A. V. Aganov & V. V. Klochkov

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  1. L. F. Galiullina
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  2. O. V. Aganova
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  3. I. A. Latfullin
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  4. G. S. Musabirova
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  5. A. V. Aganov
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  6. V. V. Klochkov
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Correspondence to V. V. Klochkov.

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Galiullina, L.F., Aganova, O.V., Latfullin, I.A. et al. NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles. BioNanoSci. 6, 352–354 (2016). https://doi.org/10.1007/s12668-016-0232-y

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  • DOI: https://doi.org/10.1007/s12668-016-0232-y

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