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Zinc-Substituted Hydroxyapatite: Synthesis, Structural Analysis, and Antimicrobial Behavior

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Abstract

Recently, ion-substituted hydroxyapatite (HAP) is gaining popularity due to the additional advantages obtained by the presence of other elements. In the current work, zinc-substituted nano-hydroxyapatite powder (Zn-HAP) has been synthesized through wet chemical synthesis process. The synthesized nano-powders were analyzed by scanning electron microscopy and X-ray diffractometry (XRD). From the results, it was evident that the produced powders were in the nano-level and without impurities. Furthermore, the XRD analysis of heated powders (1000 °C) revealed the presence of β-TCP, which was an indication that the produced powder was calcium deficient due to the substituted Zn. The results were also compared with pure HAP. Using XRD data, Rietveld refinement was carried out to assess the parameters of the unit cell and positions of ions in the Zn-HAP. The synthesized Zn-HAP powders were tested for antimicrobial properties by exposing them to two different bacterial strains; Sporosarcina pasteurii (S. pasteurii) and Escherichia coli (E. Coli). From the results, Zn-HAP was observed with a higher potential toward inhibiting the growth of the bacterium compared with that of pure HAP.

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Author notes

  1. Mohammad Irfan, Sk.Najma Sultana have contributed equally.

Authors and Affiliations

  1. Department of Metallurgical and Materials Engineering, Rajiv Gandhi University of Knowledge Technologies (AP-IIIT), Nuzvid, 521201, India

    Mohammad Irfan, Sk. Najma Sultana & B. Venkateswarlu

  2. Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai, 600036, India

    M. Jagannatham

  3. Department of Mechanical Engineering, Visvesvaraya National Institute of Technology, Nagpur, 440010, India

    Ravikumar Dumpala

  4. Department of Mechanical Engineering, Bapatla Engineering College, Bapatla, 522101, India

    B. Ratna Sunil

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  1. Mohammad Irfan
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  2. Sk. Najma Sultana
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  3. B. Venkateswarlu
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  4. M. Jagannatham
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Correspondence to B. Ratna Sunil.

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Irfan, M., Sultana, S.N., Venkateswarlu, B. et al. Zinc-Substituted Hydroxyapatite: Synthesis, Structural Analysis, and Antimicrobial Behavior. Trans Indian Inst Met 74, 2335–2344 (2021). https://doi.org/10.1007/s12666-021-02290-x

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  • DOI: https://doi.org/10.1007/s12666-021-02290-x

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